This document provides an overview of factors influencing success or failure in reducing illicit crop cultivation and controlling drug supply. It discusses the long history of human use of psychoactive substances for ritual and recreational purposes. It describes how the mass production and globalization of the late 19th century led to widespread recreational drug use. It outlines the origins and proliferation of opium and cocaine use, and the slow governmental response in regulating these drugs. It discusses how US drug policy, focused heavily on supply reduction through military-style eradication and foreign aid, has shaped international drug control efforts in recent decades.