Death begins in the cell

1. AND OTHER REVELATIONS OF ANTI-AGING
Death Begins in the
Cells…

2. ONLY ONE DISEASE ---
MALFUNCTIONING CELLS
 Never Be Sick Again By Raymond Francis
 2 causes
1. Toxins
2. Lack of nutrients
 Toxins from without ( chemicals in everyday
products you consume, use externally and in
the environment.)
 Toxins from within – free radicals from normal
metabolic action and especially when cellular
components malfunction

3. Why do we age???????
The biggest cellular culprit is oxidation, similar
to an apple slice turning brown when air
exposed.
Oxidative stress is the cell damage
associated with the chemical reaction
between free radicals and other molecules in
the body.
We’re About Health

4. ANTIOXIDANTS DETOXIFY
 They stimulate the liver to produce enzymes
that break down dangerous chemicals,
including carcinogens.
 The more kinds of antioxidants in the diet,
the more kinds of toxins the body can
disarm.
 That is why it is so important to eat many
different kinds of plants.
Without them, the cell ages.

5. 4 MECHANISMS OF CELLULAR AGING
Cellular components
Nucleu
s
DNA
Mitochondria
Energy
Genetic
Regulators
Longevity Genes
AGE
Proteins

6. ANTIOXIDANTS
 Early antioxidants .. Essential nutrients
that had antioxidant properties
Vitamin C pg: 24
Vitamin E pg: 25
 Carotenoids  CarotoMax pg: 32
 Flavonoids  FlavoMax
 Co-Q 10  CoQHeart with
Resveratrol
pg: 46

7. ANTIOXIDANT SOURCES
 NOT in meat and proteins
 NOT in dairy
 NOT in breads, pasta, sweets, snacks and
chips
Primarily in…
Vegetables and Fruits
If you don’t eat 6 to 9 servings a day …

8. Men 18-49
(No Iron)
Women 18-49
(+ Iron)
Everybody 50+
Once Daily with a Meal
Best at the start of your breakfast
26 antioxidants
VITALIZER
Pg: 14

9. Over 1000 quality tests on EACH batch, incl.:
• Over 110 tests conducted to ensure what’s
on the label is in the box
• Over 500 physical tests to ensure consistent
manufacturing
• Over 330 raw material tests
v
VITALIZER QUALITY

10. ANOTHER CLASS OF ANTIOXIDANTS
EVEN MORE POTENT
Polyphenols
Resveratrol
Ellagic Acid
and more

11. VIVIX
CELLULAR ANTI-AGING TONIC
Revolutionary breakthrough in
fight against cellular aging*
Vivix impacts the four key
mechanisms of cellular aging*
*This statement has not been evaluated by the Food and Drug Administration. This product are not intended to diagnose, treat, cure, or prevent any disease.
Pg:16-17

12. A red wine polyphenol
2,800+ publications*
• National Cancer Institute
• National Institute on Aging
• Harvard University
*Medline Pubmed search, July 22nd 2009, 2,841 citations
RESVERATROL

13. Addresses 3 of the 4 key mechanisms
of cellular aging in laboratory studies*
1 Helps protect and repair DNA*
2 Activates genetic regulators to help turn
down cellular aging*
3 Supports cellular energy (mitochondrial
biogenesis)*
Supports heart and joint health,
brain health and cognitive function*
*This statement has not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
RESVERATROL

14. Uses ULTRA-PURE
resveratrol, unlike
most products
SHAKLEE DIFFERENCE

15. Potency
One serving of Vivix™ delivers the
equivalent amount of resveratrol found in
100 glasses of red wine.

16. Shaklee Difference

17. KEY MECHANISMS OF CELLULAR AGING
1. Genetic Regulators/Longevity
Genes
 Control balance of DNA damage &
repair
 Some protect cells .. They decline with age.
 Some increase cellular damage..
They increase with age.
 Activated when cells are stressed as in
calorie deprivation ( Dr Sinclair )
 VIVIX activates longevity genes (Nrf2)
which stimulates the cells defense

18. New VIVIX Clinical Study
• State University of New York, Buffalo
• Randomized, placebo-controlled
• Healthy volunteers

19. New VIVIX Clinical Study
• 910 Cal junk food breakfast
• Measured anti-aging outcomes for 5 hrs

20. VIVIX FAST FOOD CLINICAL STUDY
STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 2 groups fed 910-calorie breakfast ( from Burger
King)
• Group 1 – no Vivix
• cells became highly stressed..
• huge inflammatory response
• free radical damage

21. FAST FOOD CLINICAL STUDY …CONTINUED
Group 2 -- 910 calorie high fat breakfast …with
Vivix
• immediately activated a key genetic molecule
Nrf2 which set in motion a
• huge cellular defense and survival
response
• Antioxidant enzymes
• Cellular detoxification pathways
• Immune response ( glutathione activated)
• Anti-stress

22. KEY MECHANISMS OF CELLULAR AGING
2. DNA Damage
 DNA is the genetic blueprint of the cell
 Controls normal cell function
 Replicates and repairs (less efficient with age)
 DNA  mRNA  Proteins
Bombarded up to a million times a day!
 Healthy immune system protects DNA
 LOTS of antioxidants required for today’s
exposure to toxins

23. KEY MECHANISMS OF CELLULAR AGING
3. Declining Cellular Energy
Production
 Mitochondria = our nuclear power plant
 Highest concentration in brain, muscle,
organs
 Antioxidants protect mitochondria
 Decline with age
 When damaged.. Create free radicals
(like nuclear meltdown)

24. KEY MECHANISMS OF CELLULAR AGING
4. Accumulation of AGE Proteins
 Advanced Glycation End products
 Cross-linked proteins (messengers inside
the cell) lose their function
 Create sludge leading to cell death..organ
death..
 Associated with diets high in sugar and
carbs

25. SHAKLEE ON THE CUTTING EDGE
 Invented whole new technology to
discover, harvest and safely produce
Vivix
 Combined resveratrol & little known
grape
 10 X more potent than resveratrol alone
 Exclusive to Shaklee

26. Muscadine (Vitis rotundifolia)
Super Grape
Extra Chromosome = Extra Health Benefits!*
20 vs. 19 chromosomes
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

27. SUPER GRAPE POLYPHENOLS
Concentrated
in Skin and Seed
Ellagic acid
Ellagitannins
Gallic acids
Anthocyanins
Proanthocyanidins
Chlorogenic acid
Quercetin
Myricetin
Caffeic acid
Kaempherol
Resveratrol
Catechins

28. ELLAGIC ACID
 Ellagic acid -- anti-proliferative and
antioxidant
 Anti-proliferative properties -- inhibits
DNA binding with certain carcinogens
(nitrosamines & polycyclic aromatic hydro
carbons)
 Reduces side effects of chemotherapy

29. • Developed for maximum cellular anti-aging
efficacy*
• Liquid FULL SPECTRUM extract
• Unique. Proprietary. Patent-pending.
• Secured exclusive supply for 20 years
from the largest and best growers world-wide
SHAKLEE SUPER GRAPE EXTRACT
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

30. 10x more powerful than resveratrol
In slowing AGE protein formation, a key mechanism of aging
SHAKLEE DIFFERENCE
Inhibition of Glycation (AGE Proteins)
0.0
20.0
40.0
60.0
80.0
100.0
0 5 10 15 20 25 30
Polyphenol Concentration (ug/mL)
Shaklee Vitis rotundifolia Extract
trans- Resveratrol

31. Gentle cold filling process
Naturally stabilized
 no artificial preservatives added
No artificial colors, flavors
or sweeteners
Purest, most potent
resveratrol
98% pure, no emodin
Ideal dosage 100 mg
VIVIX™
— ALL NATURAL

32. RESVERATROL BENEFITS UNDER STUDY
 Protects and repairs DNA
 Increases cell energy
 Activates cell anti-aging genes
 Supports brain health
 Slows AGE protein formation

33. RESVERATROL BENEFITS UNDER STUDY
 Lowers PSA levels
 Reduces risk of blood clots
 Lowers elevated blood pressure
 Slows plaque build-up in tissue
 Increases endurance and
energy
 Anti-inflammatory

34. MORE RESVERATROL BENEFITS
 Supports joint health
 Enhances immunity
 Repairs alcohol damaged liver
 Reverses or delays cardiovascular
problems
 Improves insulin and blood sugar levels
 Fights cancer.. Anti-tumor properties
 Most powerful antioxidant protection

35. RESVERATROL STUDIES ON:
Diabetes Heart Disease
Cancer Arthritis
Osteoporosis Hair Loss
High LDL cholesterol
Alzheimer's
Low HDL cholesterol Low
energy
Macular Degeneration
Degenerative Diseases

36. VIVIX REPORTS
Testimonies:
 Diabetes
 Arthritis
 Essential Tremors
 Cancer
 Age Spots
 Diverticulitis
 Energy
 Depression

37. FACTORS THAT MOST DAMAGE OUR HEALTH…
JAMIE MCMANUS, MD
Carrying excessive weight &
fat..
Obesity is the #1 factor leading to serious
illness
Solution! --
Cinch Pg: 62-63

38.  Keep muscle you have.
 Burn fat you don’t need.
 Lose inches you don’t want.
Cinch Inch Loss Plan

39. Shaklee Scientific Tradition
 12-Week Pilot Study on leucine-enhanced nutrition
program
Clinical Data
 Weight loss 15.4 lbs.
 Waist size decreased by 4.1 inches
 Hip size decreased by 2.6 inches
 Fat-free mass remained unchanged*
 all weight loss came from fat

40. The Products

41. Real People, Real Success
Dub Kruse a total of
16 inches & 71
pounds healthier*
Before

42. Real People, Real Success:
Sue Sherwood
a total of 25 inches &
25 pounds healthier*
BEFORE

43. Dieting Plateau? - Detoxify!
Additional Detox Methods
 Herb-Lax – a natural herbal laxative that
gently helps eliminate toxins from the blood,
glands, organs and tissues
pg: 38
 Alfalfa – “King of Plants” whose roots burrow
for trace elements; rich in chlorophyll, fiber
and trace minerals
pg: 29
 Liver DTX – Detox the liver and create
healthy liver cells

44. NutriFeron® Immune Support
 Created by the discoverer of
Interferon
 Naturally Increases levels of
Interferon
 Supported by Four Human
Clinical Studies
 Exclusive Patented Formula
Pg: 48

45. 10 Americans…..
 Tested for toxic chemicals
 Environmental Working Group: The
Inconvenient Truth for Environmental
Health
http://www.ewg.org/
 Kid safe chemicals act
 Watch the 10 Americans video

46. Toxins –from without or externally exposed
Sources:
 Water
 Air
 Food
 Topical
Now, let’s look at our external exposure.

47. What Chemicals Are we Using AROUND Us?
Out of 81,000 CHEMICALS REGISTERED WITH THE EPA IN THE PAST
30 YEARS, fewer than 20% have been tested for toxicity!
FACT: Poisonings—Chlorine bleach is the chemical
most frequently involved in household poisonings in the
U.S.
FACT: Asthma—Common household cleaners and
appliances may give off fumes that can be triggers for
asthma
FACT: Health Risks—Chemicals that can be found in
everyday products that are probably under your kitchen
sink or in your laundry room, basement, bathroom, and
garage are known to be harmful to children, particularly to
their developing nervous systems and brains

48. Challenges to Our Health
Today
Mercury contamination moves beyond
fish; ‘Every link of the food chain
affected’
—ABC News, September 18, 2006
Baby care products: possible
sources of infant phthalate
exposure
—Pediatrics, February 1, 2008
Bisphenol-A can build up in babies and
infants
—The Canadian Press, February 23, 2009
Too much junk food being put in
children’s hands
—World News, March 14, 2009

49. What Are we Putting ON our skin?
FACT: 287 Industrial Chemicals—Found in a test of the
umbilical cord blood of 10 newborns: consumer- product
ingredients, banned industrial chemicals, and pesticides
FACT: 1,4-Dioxane and Formaldehyde—Found in 61%
of 28 children’s bath soaps, shampoos, lotions, and other
personal care products tested; considered probable
carcinogens by the EPA
FACT: Phthalates—Fragrance can contain phthalates—
known endocrine disrupters —which are also known to
be skin irritants with potentially negative impacts on the
respiratory system, liver, and kidneys
FACT: Bisphenol-A—Found in polycarbonate plastic
containers, baby bottles, and toys—is an endocrine
disrupter; newborns and infants may have up to11X
more in their bodies than adults
Babies’ skin is 5X
thinner and more
permeable than adult
skin, making babies
more susceptible to
toxins

50. ARE YOU LIVING IN A TOXIC BODY?
Fact: Drug resistant bacteria is on the rise
Fact: Similar chemicals can act together,
along with a host of other chemicals to
create effects that no agency is looking at
Fact: 90% of toxic hazards are caused by
the inhalation of vapors and absorption of
hazardous particles
Mindfully.org

51. Solution: Shaklee
 Impeccable standards
 A commitment to products in
harmony with nature & great
health
 Change brands.

52. Our Mission—A Healthier Life for Everyone, A
Better Life for Anyone™
Shaklee—The Number One
Natural Nutrition Company in the U.S.

53. SHAKLEE PRODUCTS
LOYALTY THROUGH QUALITY

55. SAFE CLEAN
POWERFUL
CLEAN
GREEN CLEAN
SMART CLEAN
100% Satisfaction Guarantee

56. POWERFUL CLEAN
We believe you shouldn’t have to sacrifice powerful convictions for powerful
cleaners. And vice versa.
Dish Wash Liquid Concentrate
is 70% More Effective than
Method®
Dish Soap And 98%
More Effective than Seventh
Generation®
Dishwashing Liquid
on grease*
Basic H2™ Organic Super
Cleaning Wipes Perform 60%
Better than Pledge®
Wipes on
vinyl flooring*
Basic H2™ Organic Super
Cleaning Wipes Has Less
Streaking on Glass than
Windex®
With Vinegar Wipes—
plus, Get Clean™ Wipes are
biodegradable*
Nature Bright®
Laundry
Booster and Stain Remover
is 50% More Effective than
OxiClean® on grass stains*
Fresh Laundry Liquid
Concentrate is 30% Better
at removing soil and stains than
All Small & Mighty™*
Fresh Laundry Liquid
Concentrate Outperforms
Shout®
and Spray ‘n Wash®
on
spot removal*
*These performance
comparisons were done on
March 29, April 24, and June
6, 2006 and are valid only
for the named products
marketed at that time. All
trademarks are the property
of their respective owners.

57. STARTER KIT
You would spend over $3,400 to get the
same cleaning power from major name brands!*
60 Bottles of Fantastik®, 32 oz.
32 Bottles of Mop ‘n Glo®, 32 oz.
728 Bottles of Windex®, 26 oz.
1 Bottle of Woolite®, 50 oz.
1 Container of Clorox® Wipes
1 Bottle of Soft Scrub®
2.5 Boxes of Cascade®, 45 oz.
2 Boxes of Tide®, 50 oz.
3 Bottles of Downy®, 20 oz.
1 Box of Bounce®

58. Personal Care
Page: 96-97

59. Nutrition Therapy
Skin Care System™
Enfuselle®
blocks ALL
skin-
damaging
free radical
reactions
Page 80

60. Formulated Without:
•Parabens
•SLS/SLES
•Propylene glycol
•Animal products or by-
products
•Mineral oils or petrolatum
•FD&C or D&C dyes
•Phtalates
•1,4-dioxane

61. Results so dramatic…
…even we did a double take!
In 28 days, clinical studies confirmed*:
• 665% increase in skin firmness
• 421% reduction in the
appearance of wrinkles
• 88% reduction in fine lines
So unique and proprietary, Enfuselle®
has been granted 7 patents

62. Vital Repair +
®
Complex
Boosts your skin’s natural ability to defend and repair its
appearance.
Black & white photography
Normal Light
`
UV Light
Before regimen treatment After regimen treatment
Damage is not
noticeable
Dark areas show
underlying damage
Visibly diminished damage

63. Changing brands changed her life…

64. Always safe:
 Clinically tested
 No parabens, 1,4-dioxane, sodium lauryl
sulfate, formaldehyde, or phthalates
Always gentle:
 Pediatrician tested
 99% natural ingredients
 76%–99% organic ingredients
 Hypoallergenic
 pH balanced
Always healthy:
 No synthetic fragrances
 No artificial colors
 Packaging is free of bisphenol-A,
phthalates, and toxic inks
Page 72-73
Specifically designed for your baby’s tender skin.
Baby Care:

65. We’re About Health on the inside, too….
For Our Kids….
Start with
HEALTHY eating
Supplement
Essential Nutrients
that growing bodies
NEED.
Page: 74-77

66. We’re About Health
Put SAFE Products IN Us

67. We’re About Health
Put SAFE Products ON Us

68. We’re About Health
Use SAFE Products AROUND our home
®
®

69. Welcome
to Peace
of Mind

70. !
©2008 Shaklee Corporation. Distributed by Shaklee Corporation, Pleasanton, CA 94588 08-477 (Rev. 9/08)