explains in detail regarding different histopathological bodies in dermatology

1. Shumez .H.
Bodies in Dermatology

2. Classification
 Normal cutaneous anatomy
Glomus bodies, Lamellar bodies, Weibel
palade bodies
 Hair disorders
Arao Perkin bodies, Papillary mesenchymal
bodies
 Granulomatous disorders
Asteroid bodies, Schaumann bodies
 Papulosquamous disorders
Civatte bodies, Corp ronds and grains

3.  Metabolic & storage disorders
Banana bodies, Caterpillar bodies, Farbers
bodies, Lafora bodies, Zebra bodies, Alder
Reilly bodies
 Tumors
Dutcher bodies, psammoma bodies, Pustulo –
ovoid bodies of Milian, Verocay bodies
 Histiocytic disorders
Comma shaped bodies
 Benign pigmented lesions
Kamino bodies

4.  Collagen vascular disorders
Cytoid bodies, LE
 Age related change
Pertinax bodies
 Drug induced
Heinz bodies
 Infectious disorders
Dohle bodies, Mallory bodies, Michaelis –
Gutmann bodies, Russell bodies, Donovan
bodies, Cigar bodies, Medlar bodies, Guarnieri
bodies, Henderson Patterson bodies, Cowdry A

5. Glomus bodies
 Specialized arterio venous shunts that connect
an ateriole with a venule without the
interposition of capillaries.
 Abundantly found in the pads and nail beds
of fingers and toes.
 Concerned with temperature regulation.

7. Lamellar bodies
 A.k.a Odland bodies, Cementosomes.
 Round – oval granules that possess a highly
ordered lamellar internal structure.
 Contain bipolar phospholipids, glycoproteins,
and acid phosphatases.
 Measure 300 nm.
 Located in the cytoplasm of cells of upper
spinous and granular layer.

8.  Play an important role in barrier function and
intercellular cohesion within stratum corneum.
 Abnormal formation and secretion of lamellar
bodies seen in Harlequin Icthyosis.

9. Weibel – Palade bodies
 An electron dense cytoplasmic organelle.
 Measures 0.1 µ in diameter and 3 µ in length.
 Composed of a number of tubules arranged
in the long axis of the rod.
 Endothelium specific inclusions.
 Contain Von Willebrand factor, P – selectin, and
CD63.

11. Arao – Perkin bodies
 Begin as a small cluster of elastic fibers in
the neck of the dermal papilla.
 They clump in the catagen.
 With progressive shortening of the anagen in
AGA, multiple elastic clumps may be found in
the stellae, like rungs of a ladder.

12. Papillary Mesenchymal bodies
 Constitute clusters of fibroblasts adjacent to
epithelial buds as in the germinative portion
of the normal hair papilla.
 Observed in trichoepitheliomas.

14. Asteroid bodies
 Star shaped eosinophilic structures with a
centre that is brown red and radiating blue
spikes within histiocytes or multinucleated
giant cells.
 Measure 10 – 15 µ in size.
 Contain collagen showing 64 – 70 nm
periodicity. ( collagen trapped in epitheliod cells )
 Seen in Sarcoidosis, Sporotrichosis, and Actinic
granuloma.

16. Schaumann bodies
 A.k.a. Conchoidal bodies.
 Basophilic concentric lamellar structures
 Measure 100 µ in size.
 Composed of lipomucoglycoproteins
impregnated with calcium and iron.
 Show central birefringent crystals.
 Seen in Sarcoidosis, Tuberculosis.

18. Banana bodies
 Cresentic shaped bodies within Schwann
cells.
 Seen in disseminated lipogranulomatosis.

19. Caterpillar bodies
 Epidermal eosinophilic bodies that are
elongated and sometimes segmented.
 Ultrastructurally, they have cellular organelles,
colloid and electron dense material.
 They form the roof of the blister in Porphyria
Cutanea Tarda.

20. Farber’s bodies
 Curvilinear bodies within cytoplasm of
fibroblasts and occasionally of endothelial
cells.
 Also found within phagosomes of histiocytes
at various stages of degradation.
 Seen in Farber’s disease.

21. Lafora bodies
 A.k.a. Polyglucosan bodies
 Bodies seen in the excretory ducts of eccrine
and apocrine sweat ducts of clinically normal
skin.
 Seen in Lafora disease - dementia, myoclonus,
seizures, rarely skin lesions.

23. Zebra bodies
 Vacuoles with transerve membranes within
endothelial cells.
 Seen in Farber’s disease and various other
ganglioside storage disorders.

25. Alder Reilly bodies
 Deeply basophilic granules seen within
neutrophils and sometimes within lymphocytes
and monocytes.
 Contain incompletely degraded
mucopolysaccharides.
 Seen in mucopolysaccharide storage disorders
like Hunter’s syndrome, Hurler’s syndrome

27. Dutcher bodies
 Eosinophilic intranuclear pseudo inclusions
within plasma cells.
 Formed by a cytoplasmic invagination into the
nucleus.
 They are smooth, membrane bound and
surrounded by clumped chromatin.
 Seen in Lymphoplasmacytic lymphoma, Mucosa
associated lymphoid tissue (MALT), myeloma,
Waldenstrom Macroglobulinemia.

29. Psammoma bodies
 Concentrically laminated, hyalinized or calcified
basophilic structures.
 Seen in cutaneous meningioma.

31. Pustulo – Ovoid bodies of Milian
 Large eosinophilic intracytoplasmic granules
surrounded by a clear halo.
 Seen in granular cell tumour of tongue.

32. Verocay bodies
 Two neighbouring palisades, intervening
cytoplasm of schwann cells and associated
reticular fibers all in combination constitute a
verocay body.
 Seen in Schwannomas.

34. Civatte bodies
 A.k.a. Colloid, Cytoid, Hyaline, Sabaroud
bodies.
 Necrotic keratinocytes measuring 20 µ in
diameter and possessing a homogenous
eosinophilic appearance.
 Located in the lower epidermis, especially in
the papillary dermis.
 Seen in GVHD, Lichen planus, Lichen nitidus,
drug reactions, Lupus erythematosus, Lichenoid
actinic keratoses, and even normal skin.

36. Corp Ronds and Grains
 Dyskeratotic cells found as solitary or small
groups of separated cells in the upper
malpigian layer and stratum corneum.
 Small pyknotic nucleus, clear perinuclear halo
and brightly eosinophilic cytoplasm.
 Grains are small cells with elongated nuclei
and scanty cytoplasm in upper layers of
epidermis.
 Seen in Darier’s disease.

38. Comma shaped bodies
 Seen within histiocytes.
 Formed by two electron dense membranes of
6 nm, separated by a light space of 8 nm.
 Seen in Juvenile xanthogranulomas, benign
cephalic histiocytosis, sinus histiocytosis.

39. Kamino bodies
 Eosinophilic globules seen in basal layer
above the tips of dermal papilla.
 Found in Spitz nevi, melanomas and other
nevi.

41. Cytoid bodies
 Localized areas of swelling in the inner layers
of retina, predominantly involving the nerve
fibre layer.
 Confined to the posterior fundus.
 Contain giant globular bodies with round or
oval eosinophilic inclusions.
 Fundal Cytoid bodies seen in SLE,
dermatomyositis, PAN, scleroderma and giant
cell arteritis.

43. LE bodies
 Following the nuclear penetration of
traumatised leucocytes by the LE cell factor,
the altered nucleus detaches itself from the
cytoplasm and appears as a free extracellular
LE body.
 Appears as homogenous, pale blue to deep
purple material pushing the nucleus of the
phagocyte to one side of the cell.
 Seen in SLE.

45. Pertinax bodies
 Acidophilic masses which represent remnants
of keratinocyte nuclei.
 Seen in senile nails.

46. Heinz bodies
 Blue inclusions within RBCs composed of
denatured haemoglobin.
 Appear as single or multiple inclusions of 2 µ
in diameter and often appear attached to the
membrane.
 Seen in drug reactions to dapsone,
chloroquine, etc.

48. Dohle bodies
 Small, basophilic, rounded – oval or rod shaped
bodies chiefly in the periphery of
polymorphonuclear leucocytes
 Seen in scarlet fever.

50. Mallory bodies
 Located intranuclearly within epidermal cells or
lay within lymph spaces.
 Made up of a delicate reticulum which stains
light blue and the surrounding protoplasm
pink.
 Seen in measles and scarlet fever.

52. Michaelis – Gutmann bodies
 Ovoid – round basophilic inclusions that vary
in size from 5 -15 µ and are seen in granular
Von Hansemann histiocytes.
 They are either homogenous or have a target
appearance by showing concentric
laminations.
 Seen in Malakoplakia.

54. Russell bodies
 Homogenous, elliptical, intracytoplasmic
eosinophilic inclusions seen within plasma
cells.
 20 – 40 µ in diameter.
 Seen in Rhinoscleroma.

56. Cigar bodies
 At 37˚ C, Sporothrix schenckii may be present
in the tissue as a yeast like form 2 - 8 µ in
diameter or as elongated cigar bodies 4 - 10 µ
in length.
 Seen in Sporotrichosis.

57. Medlar bodies
 A.k.a. Sclerotic bodies, Muriform cells, Copper
pennies.
 Dark brown, thick walled, ovoid or spherical
spores varying in size from 6 – 12 µ, lying
singly, in clusters or in chains within
histiocytes in microabscesses as well as free
within the tissue.
 Seen in Chromomycosis.

59. Leishman Donovan bodies
 The cytoplasm of histiocytes is filled with
numerous dull blue – grey, round to oval
bodies that exhibit a round basophilic nucleus
and a rod shaped paranuclear kinetoplast.
 Measure about 2 – 4 µ in diameter.
 Seen in Leishmaniasis.

61. Guarnieri bodies
 A.k.a. Paschen bodies.
 Intracytoplasmic eosinophilic aggregation of
virus particles.
 Seen in Variola, Vaccinia, Human cowpox,
Parapox.

63. Henderson – Patterson bodies
 Ovoid, eosinophilic structures in the lower cells
of the stratum malpighii.
 They increase in size as the infected cells
move towards the surface.
 In the upper layers of the epidermis, the
molluscum body compresses the nucleus of
the cell so that it appears as a thin crescent
at the periphery of the cell.
 Seen in Molluscum contagiosum.

65. Cowdry A bodies
 A.k.a. Lipschutz inclusions.
 Intranuclear eosinophilic inclusions surrounded
by a clear halo.
 Measure 3 – 8 µ in diameter.
 Seen in herpes simplex and Varicella Zoster
lesions.

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