3. 3
Impax at a Glance
Generics Division
Targeting high-value solid oral and alternative dosage
form ANDAs that are difficult to develop
• Diversified commercial portfolio of ~72 products
including epinephrine auto-injector, oxymorphone ER
• 23 ANDAs pending approval at FDA including
gRenvela®, gWelchol®, gConverta®, gVytorin®
• 20 ANDAs under development
Specialty Pharma Division
Focused on developing branded Central Nervous
System disorder and other specialty products
• 5 commercialized products including Rytary®, Zomig®
Nasal Spray, Albenza®, Emverm®
• 1 under development - IPX203 next generation Rytary
Pipeline data as of Feb. 24, 2017
A specialty pharmaceutical company applying its formulation expertise and
drug delivery technology to the development, manufacturing and marketing of
specialty branded and generic products
4. 4
Leveraging Our Strengths and Focusing on
Opportunities for Growth
➢ Ensure effective and compliant marketing and sales execution of
specialty products and high-value/difficult-to-formulate generic products
➢ Continue focus on sustainable quality and compliance programs
➢ Select the right products for internal and partnership development
➢ Develop, file and launch on time and capitalize on market opportunities
Leveraging
Our Strengths
➢ Maximize value in Rytary® and invest in IPX203
➢ Improve cost of goods sold and supply chain flexibility
➢ Reduce expenses by identifying additional efficiency opportunities
➢ Increase productivity from internal R&D programs
➢ Diversify via select partnering and business development activities in
both brand and generic businesses
Focusing on
Opportunities
to Drive
Growth
➢ Took steps to reduce costs and improve efficiencies; expected to
produce estimated annual savings between $40MM and $50MM by 2018
➢ Ongoing thorough review of product portfolio and cost structure, which
will provide incremental operational opportunities
Operating
Efficiently
5. 5
Cost Optimization: What We’ve Achieved and 2017 Focus
Completed/In-Process
Estimated Annual Savings
~$40MM-$50MM*
Operational and R&D
restructuring (2015)
Closed central packaging
operation/transferred distribution
to UPS (2015)
Closing Middlesex, NJ
manufacturing and packaging
facility (2017)
Current Initiatives
Confidence in 2017 Cash Flow to
Service Debt & Fund R&D
$50MM voluntary payment
toward term loan late Feb. 2017
Comprehensive portfolio review
and facility utilization analysis
Thoroughly reviewing all cost
functions to identify cost saving
initiatives
*Based on estimates as of Dec. 31, 2016. Currently expect to realize full annual savings beginning in 2018.
Aligning organization and resources to support growth initiatives
and reduce long-term debt
7. 7
During 2016…
➢ Completed sales force expansion to 116 reps
➢ Redefined clinical messaging related to formulation and simplified dose conversion
guidance for general neurologists
➢ Launched myRytary Patient Support Program www.myrytary.com
2017 developments…
➢ April 1st, CVS Caremark, moving Rytary on their National Formulary from “Not Covered”
to “Non-Preferred Brand” without edits ~26MM commercial patients
Actions Taken to Deliver Growth
0%
1%
2%
3%
0
2,000
4,000
6,000
8,000
10,000
12,000
14,000
Dec-15 Jan-16 Feb-16 Mar-16 Apr-16 May-16 Jun-16 Jul-16 Aug-16 Sep-16 Oct-16 Nov-16 Dec-16 Jan-17
CDLDShare
TRx
Monthly TRx and Share of National CD-LD TRx
Rytary TRx CD-LD Share
(a) Rytary was launched in Feb. 2015.
Source: IMS NPA Monthly Jan. 2017
74% revenue and 114% TRx growth in 2016(a)
8. 8
Specialty Pharma R&D: IPX203 Next Generation Rytary
Investigator Assessment of Motor State
Off Time (h) On Time (h)
Immediate-release CD-LD 7.3 2.7
Rytary 5.5* 4.4*
IPX203 4.6 * + 5.4 * +
* p ≤ 0.0002 compared to IR CD-LD
+ p < 0.05 compared with Rytary
Improvement from Baseline in
MDS-UPDRS Part III
➢ Designed to achieve rapid and sustained levodopa concentration, improved motor
benefits and less frequent dosing
➢ Ongoing Phase 2b multiple dose study in patients with advanced Parkinson’s disease
➢ Phase 2b interim results by end of first half 2017
Positive Phase 2a Study
11. 11
U.S. Generics Overview: A Diversified Portfolio
SOD – Solid Oral Dose; Data as of Feb. 24, 2017
Product Portfolio by Number of
Competing Generic Products
Sole player in market 10%
One 13%
Two 21%
Three 18%
Four or more 38%
62% of Impax’s commercialized portfolio have three or fewer
competing products
Diversified Portfolio of 72
Commercialized Products
▪ 50 immediate-release solid oral
▪ 13 controlled-release solid oral
▪ 9 alternative dosage form
12. 12
➢ Expanded production/supply
➢ Enhanced greater awareness
▪ The “Go To Choice”
▪ Significantly expanded preferred drug list status
▪ CVS agreement
➢ 2016 revenue of $92MM; up 139% over 2015
Generics Business Highlights in 2016
IMS NPA Weekly Feb. 17, 2017
0%
5%
10%
15%
20%
25%
30%
Epinephrine Auto-Injector
Share Growth
Jan. 1, 2016 – Feb. 17, 2017
4%
26%
0%
10%
20%
30%
40%
50%
60%
70%
Oxymorphone ER
Share Growth
Jan. 1, 2016 – Feb. 17, 2017
7.5 & 15 mg 5, 10, 20, 30 & 40 mg
34%
46%
➢ Sole generic player
➢ Captured share of exiting generic player
➢ 2016 revenue of $73MM; up 23% over 2015
48%
58%
Despite Industry challenges, several products in the generic
portfolio delivered strong growth
13. 13
Investing to Expand Pipeline Opportunities
Generic R&D
16
14
7
6
Pending at FDA
$14B
Under Development
$10B
Solid Oral Dose Alternative Dose
23
20
# of Potential
Products
FTF or FTM
8 17
Portfolio of 43 Products
Current U.S. Brand/Generic Market of $24B
Pipeline provides solid platform for growth
Disclosed Pending/TA ANDAs
Greneric Product Name
(BOLD Potential FTM Opportunity)
Brand
IMS
Sales
Oxycodone ER tablet (new formulation) 1 OxyContin® $2.3B
Sevelamer Carbonate IR tablet Renvela® $1.9B
Methylphenidate HCI ER tablet Concerta® $1.8B
Teriflunomide IR tablet Aubagio® $1.1B
Ezetimibe/Simvastatin IR tablet – TA 2 Vytorin® $690M
Colesevelam IR tablet Welchol® $635M
Oxymorphone ER tablet (new formulation) Opana ER® $305M
Fentanyl Buccal IR tablet Fentora® $143M
Dutasteride/Tamsulosin IR capsule Jalyn® $46M
Risedronate Sodium DR tablet Atelvia® $31M
Source of sales data: IMS NPS Dec 2016; Pipeline data as of Feb 24, 2016; TA = tentative approval
1 Launched authorized generic in April 2016
2 Assuming final FDA approval, earliest potential launch date/timing based on settlement or patent
expiration date
FTF – First-to-File; FTM – First-to-Market
14. 14
2017 Priorities
Focus on quality and operations
Effectively execute on Specialty product growth initiatives
Maximize profitability within generic portfolio
Capitalize on new generic product launches
Continue to build diversification within our portfolio
Explore additional expense savings and efficiency opportunities