2. INTRODUCTION
Infertility is define as couple’s inability to achieve pregnancy
following one year of appropriately timed and unprotected
intercourse. Infertility effect about 10% of all couple. 20-30% of
infertility cases are due to male infertility, 20-35% are due to, and
25-40% female infertility are due to combined problems in both
parts. In 10-20% of cases, no cause is found
3. Definition
Infertility
infertility is defined as failure to conceive within one or two more year of
regular unprotected intercourse.
Sub-fertility
Sub-infertility refer to a state in which a couple has tried unsuccessfully to have
a child for year or more. The term sub-fertile means less fertile than regular
couple.
Primary infertility
primary infertility denote couples who have never been able to conceive.
Secondary infertility
4. FACTOR REQUIRED FOR FERTILITY
For male and female
Healthy spermatozoa
Motility
Ovulation
Patent fallopian tube
Transportation of fertilized ovum to
uterine cavity
Acrosome reaction
6. CAUSES IN MALE
DEFECTIVE SPERMATOGENESIS
Congenital
Hypospadias
Thermal factor
Infection
Gonadotropin suppression
Endocrine factor
Loss of sperm mobility
Genetic
Iatrogenic
Immunological factor
OBSTRUCTION OF THE EFFERENT DUCTS
7. Cont…….
FAILURE TO DEPOSIT SPERM HIGH IN
VAGINA
Erectile dysfunction
Ejaculatory defect such as retrograde,
premature, absence of ejaculation
Hypospadias
ERROR IN SEMINAL FLUID
Unusually high or low volume of ejaculate
Low fructose content
High prostaglandin content
Undue viscosity.
8. CAUSES IN FEMALE
OVARIAN FACTOR
An-ovulation or oligo-ovulation.
TUBAL AND PERITONEAL FACTOR
Peritubal adhesion
Endosalpingeal damage
Salpingitis
Previous tubal surgery or sterilization
Tubal or peritoneal endometriosis
Polyps within lumen
Tubal spasm
9. UTERINE FACTOR
Uterine hyperplasia
Inadequate secretary endometrium
Fibroid
Endometritis
Congenital malformation
CERVICAL FACTOR
Chronic cervicitis
Presence of anti sperm antibody
Congenital elongated of cervix
Second degree uterine prolapse
Acute retroversion of uterus
Occlusion of cervical canal with polyp
Pinhole OS
Scanty vaginal mucus
10. VAGINAL FACTOR
Atresia
Septum
Narrow introitus
COMMON FACTOR
Age of wife beyond 35 and advance age in
male.
Infrequent intercourse during fertile
period
Failure of emission of sperm/ejaculation
Anxiety
Use of lubricant
Immunological factor
12. HISTORY TAKING
General History
Medical history
Surgical history
Menstrual history
Pervious obstetric history
Contraceptive practice
Sexual problem
INVESTIGATION FOR FEMALE
13. PHYSICAL EXAMINATION
General examination : obesity, abnormal
distribution of hair, under development of
secondary characteristic.
Systemic examination : hypertension,
organic heart disease, chronic renal
disease.
Gynecological examination : evidence of
vaginal infection, elongation of cervix,
uterine size.
Speculum examination : cervical discharge
14. DIAGNOSTIC EVALUATION
• Menstrual history
• Basal body temperature
• Hormonal estimation
• Endometrium biopsy
• hysterosalpingography
• Sonography
• Laparoscopic chromotubation• Sonosalpingography
• Insufflation test
16. General medical history
• Diabetes
• Recurrent chest infection
• Bronchiectasis
• Mumps orchitis after puberty
• Surgery such as herniorrhaphy
• Operation on tests
• Erectile dysfunction
• Heavy smoking and alcohol
Diagnostic evaluation
• hormonal test
• Testicular biopsy
• Transrectal ultrasound
• Karyotype analysis
18. GENERAL INSTRUCTION
oBODY WEIGHT
oSMOKING AND ALCOHOL
oIDEAL COTIAL FREQUENCY
oUSE OF LH SURGE KIT
oAVOIDANCE OF LUBRICANTS
AND DOUCHES TO BE STRESSED
oPSYCHOLOGICAL EFFORT
19. MANAGEMENT IN MALE
GENERAL CARE
IMPROVEMENT OF GENERAL HEALTH
AVOIDING MEDICATION THAT INTERFERE WITH
SPERMATOGENESIS
MEDICATION THAT TREAT SPECIAL CAUSES LIKE
ANTICONVULSANT
SPECIAL TREATMENT : INTRAUTERINE INSEMINATION, INVITR
FERTILIZATION, INTRACYTOPLASMIC SPERM INJECTION.
SURGICAL TREATMENT : TESTICULAR BIOPSY
CORRECTION OF HYDROCELE.
20. FEMALE INFERTILTIY
MANAGEMENT
ovulatory dysfunction
surgery
• laproscopic ovarian drilling
• surgical removal of virilizing
• cannulation and balloon tuboplasty for block
in treatment
• salpingostomy to create opening in tube in a
completely occluded tube
22. TECHNIQUE OF ART
Intrauterine insemination (IUI)
In-vitro fertilization and embryo transfer (IVF-ET)
gamete intra-fallopian transfer (GIFT)
zygote intra-fallopian transfer (ZIFT)
Intra cytoplasmic sperm injection (ICSI)
23. Intrauterine insemination (IUI)
It involve placing increasing concentration of
motile sperm close to fallopian tube by passing
endocervical canal.
Indication
• Cervical stenosis
• Oligo-spermia
• Immune factor
• Unexplained infertility
• Anatomical defect
These are of type
1. Artificial insemination donor
2. Artificial insemination husband
24. In-vitro fertilization and embryo transfer (IVF-ET)
The fertilization of ovum
occur outside the body
technique is used in
blocked fallopian tube.
Indication
• Tubal disease
• Endometriosis
• Cervical hostility
• Unexplained infertility
25. gamete intra-fallopian transfer (GIFT)
In this procedure both the
sperm and unfertilized oozyte
are transferred into fallopian
tube using laparoscopy
following transvaginal ovum
retrieval
26. zygote intra-fallopian transfer (ZIFT)
In zygote intrafallopian transfer,
egg cells are removed from the
women’s ovaries and fertilized in
lab. The resulting zygote is then
placed in fallopian tube
following one day invitro-
fertilization through laproscope
or through uterine opening
under ultrasonic guidance. The
technique is suitable alternative
to gift
27. Intra cytoplasmic sperm injection (ICSI)
This method is beneficial in case of
male factor infertility where the sperm
count are low or failed fertilization
with previous IVF attempts. The
procedure involve single sperm
carefully injected into center of egg
using a micro-needle.
Indication
• Sever oligospermia
• Sperm antibodies
• Obstruction of afferent duct
system
28.
29. Legal and ethical aspect of ART
1.Clinics should be registered
2. Code of practice
• Staff
• Facilities
• Confidentiality
• Information to patient
• Consent
• Counselling
• Use gametes and embryo
• Storage and handling the gametes and embryo
• Research
• Complaints
30. Cont……
3.Responsibility of clinic
• Maintance of detail record
• Take DNA finger print of
donor/child/couple/surrogate mother if couple
agrees.
• Keep information confidential
• Display the charge suitably or made down to
known to patient at beginning of treatment.
Ensure that no. technique is used on patient which
demonstrated expertise.
32. ADOPTION
It is legal process by which a child is placed with married couple or single
female who agree to rise her as their own child and assume responsibility
for her.
Law governing adoption
• Hindu adoption and maintenance act of 1956
• Guardian and ward act of 1890
• Juvenile justice act of 2000
33. Condition to be fulfilled by an adoptive
parent.
Medically fit and financially able to care for
child
Must be at least 21 yr. age
No legal upper age limit for parents
Adoption of older age children, age of
parents will be relaxed
Adoption of child with special needs, the age
limit of parents will be relaxed
If adoption is son/ daughter, the adoptive
father or mother by whom the adoptive is
made must nit have same gender living at
time of adoption.
34. HINDU ADOPTION AND MAINTENANCE ACT-
1956
PREOCESS
Step1- registration
Step2-home study and counselling
Strp3-referral of child
Step4-acceptance of child
Step5-filing of petition
Step6-court hearing
Step7-court order
Step8-follow up