Is there any reason that mitosis could not occur in a cell whose genome is haploid? Why or why not? Relate your answer to the way chromosomes line up for metaphase in mitosis. Solution Answer: Haploid cells can undergo mitosis. It is beneficial for some plants and protists, the end result is two identical haploid cells (nn). Some plants use the alternation of generations reproductive cycle. A haploid gamete is mitotically reproduced. Mitosis is much quicker than meiosis, allowing for many haploid gametes to be produced. Example: Gametophyte of Bryophyte plants. It is produced from mitotic cell division of spores, which are produced by meiosis in sporophytes. During S-phase, DNA gets duplicated with each chromosome containing 4 chromatids. The chromosomes line up at the center of the cell during metaphase. The centromeres split and divide each chromosome into two which migrate to the opposite poles during anaphase..