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New Horizons in Bariatric Surgery – endoluminal treatments for weight regain after gastric bypass: Elliot R Goodman MD Bariatric Surgery Service  Beth Israel Medical Center New York, NY
Background ,[object Object],[object Object],[object Object],Pories WJ, Swanson MS, MacDonald KG.  Who would have thought it?  An operation proves to be the most effective therapy for adult-onset diabetes mellitus.  Ann Surg 1995;222:339-350.
Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gagner M., et al.  Laparoscopic Reoperative Bariatric Surgery :  Experience from 27 consecutive patients.  Obes Surg, (12) 254-260, 2002.
Weight loss  trajectory after gastric bypass:
Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Jones KB. Revisional bariatric Surgery-potentially safe and effective.  SOARDS 1 (2005) 599-603
Background: ,[object Object],[object Object],[object Object],[object Object]
Endoluminal Gastric Pouch Reduction (EGPR) StomaphyX TM
Endoluminal Gastric Pouch Reduction ,[object Object],[object Object],[object Object],[object Object],[object Object]
Endoluminal Gastric Pouch Reduction ,[object Object],[object Object],[object Object],[object Object],[object Object]
Diagram for fasteners H H H H H H
Endoluminal Gastric Pouch Reduction
Endoluminal Gastric Pouch Reduction Pre anastomosis Post anastomosis
Endoluminal Gastric Pouch Reduction Gastro-esophageal Junction
Fluoroscopic evidence of stomal narrowing after EGPR with Stomaphyx: GJ stoma before EGPR Stoma after EGPR
Serosa-to-serosa Fusion Full thickness tissue plication and serosa-to-serosa  fusion seen in several animal models
Beth Israel Medical Center results 2008-9 (N=64) 5 (2-10) Median time(years) after Gastric bypass surgery 31.3 Median BMI Post-GB(nadir) 31.3 Median BMI Post-Gastric Bypass (nadir) 48.7 Median BMI Pre-Gastric Bypass 65 Height (inches) 92% female / 8% male Female / Male 47.5  (24-66) Age (years)
7(12%) No follow up weight available 14(21%) No. Patients no weight loss 43(67%) No. Patients Weight loss 6(1-13) Median follow up(months) 37.75(25.1-55.2) Median BMI post Stomaphyx 39.85 (25.9-54.9) Median BMI before StomaphyX
23(10-40) Median # of fasteners 33%(0-67) Median reduction in gastric pouch length 50 (35-130) Median OR time 15.5(3.3-67) Median weight loss (lbs.) post StomaphyX
RESULTS: ,[object Object],[object Object]
Endoluminal Gastric Pouch Reduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Latest data pooled  from 3 large US centers  (BIMC, OSU and Alvarado Hospital): ,[object Object],[object Object],[object Object],[object Object]
Latest data (con): ,[object Object],[object Object],[object Object],[object Object]
Predictive factors: ,[object Object],[object Object]
Endoluminal Gastric Pouch Reduction ,[object Object],[object Object],[object Object],[object Object],[object Object]
The ROSE Procedure (by USGI):
Stomal reduction with ROSE: Diameter 2.6cm Diameter 0.5cm
Stoma/Pouch Reduction Achieved Cases Completed  N=112/116  (97%) Mean Final Stomal Diameter 11.5 mm Mean % Stomal Reduction 50% Mean Final Pouch Length  3.3 cm Mean % Pouch Reduction per Case 44% Mean # Total Anchors per Case 5.9 Mean O.R. Time 87 min
Results-6 Month Weight Loss  *based on target BMI 25kg/m 2 6 Month Endpoint (N=96) Mean for  Total Registry Max for Individual Subject Weight Loss (kg) 6.5kg 30kg %EWL* 18% 84% % Regained Weight Lost (RWL) 32% 300%
Conclusions: ,[object Object],[object Object],[object Object],[object Object]

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New Horizons in Gastric Surgery

  • 1. New Horizons in Bariatric Surgery – endoluminal treatments for weight regain after gastric bypass: Elliot R Goodman MD Bariatric Surgery Service Beth Israel Medical Center New York, NY
  • 2.
  • 3.
  • 4. Weight loss trajectory after gastric bypass:
  • 5.
  • 6.
  • 7. Endoluminal Gastric Pouch Reduction (EGPR) StomaphyX TM
  • 8.
  • 9.
  • 10. Diagram for fasteners H H H H H H
  • 12. Endoluminal Gastric Pouch Reduction Pre anastomosis Post anastomosis
  • 13. Endoluminal Gastric Pouch Reduction Gastro-esophageal Junction
  • 14. Fluoroscopic evidence of stomal narrowing after EGPR with Stomaphyx: GJ stoma before EGPR Stoma after EGPR
  • 15. Serosa-to-serosa Fusion Full thickness tissue plication and serosa-to-serosa fusion seen in several animal models
  • 16. Beth Israel Medical Center results 2008-9 (N=64) 5 (2-10) Median time(years) after Gastric bypass surgery 31.3 Median BMI Post-GB(nadir) 31.3 Median BMI Post-Gastric Bypass (nadir) 48.7 Median BMI Pre-Gastric Bypass 65 Height (inches) 92% female / 8% male Female / Male 47.5 (24-66) Age (years)
  • 17. 7(12%) No follow up weight available 14(21%) No. Patients no weight loss 43(67%) No. Patients Weight loss 6(1-13) Median follow up(months) 37.75(25.1-55.2) Median BMI post Stomaphyx 39.85 (25.9-54.9) Median BMI before StomaphyX
  • 18. 23(10-40) Median # of fasteners 33%(0-67) Median reduction in gastric pouch length 50 (35-130) Median OR time 15.5(3.3-67) Median weight loss (lbs.) post StomaphyX
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25. The ROSE Procedure (by USGI):
  • 26. Stomal reduction with ROSE: Diameter 2.6cm Diameter 0.5cm
  • 27. Stoma/Pouch Reduction Achieved Cases Completed N=112/116 (97%) Mean Final Stomal Diameter 11.5 mm Mean % Stomal Reduction 50% Mean Final Pouch Length 3.3 cm Mean % Pouch Reduction per Case 44% Mean # Total Anchors per Case 5.9 Mean O.R. Time 87 min
  • 28. Results-6 Month Weight Loss *based on target BMI 25kg/m 2 6 Month Endpoint (N=96) Mean for Total Registry Max for Individual Subject Weight Loss (kg) 6.5kg 30kg %EWL* 18% 84% % Regained Weight Lost (RWL) 32% 300%
  • 29.

Editor's Notes

  1. Update to 67 patients
  2. Fix this. Reops?
  3. Make numbers bigger
  4. Make numbers bigger