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Revision of RYGBP (Weight loss failures) (Weight loss failures) <ul><li>Kelvin D Higa, MD, FACS, FASMBS </li></ul><ul><li>...
Who failed whom? <ul><li>The “bad” patient </li></ul><ul><li>The “program” </li></ul><ul><li>Compliance </li></ul><ul><li>...
“ Since all types of bariatric operations can be defeated, it is virtually impossible to assign all of the “blame” for poo...
GBP considerations <ul><li>Gastric bypass is not standard - Varying pouch sizes and orientations - Variable limb lengths -...
GBP considerations <ul><li>Psychological issues can be addressed, but usually never resolved </li></ul><ul><li>Optimizatio...
Anatomic Optimization <ul><li>POUCH </li></ul><ul><li>ANASTOMOSIS </li></ul><ul><li>BYPASS </li></ul>
The Anastomosis
19±9 lb 23±17 lb ±5 lb
<ul><li>71 patients </li></ul><ul><li>< 50% EWL or 5% weight gain after GBP </li></ul><ul><li>26 month follow-up </li></ul...
Stoma Reduction <ul><li>Spaulding L.  Treatment of dilated gastrojejunostomy with sclerotherapy. Obes Surg 2003;13:254 –7 ...
<ul><li>Herron D, Birkett D,  Thompson C, Bessler M, Swanstrom L. Gastric bypass pouch and stoma reduction using a transor...
Endoluminal <ul><li>Thompson 2006 - 8 patients; 10 kg @ 4 months Bard Endocinch </li></ul><ul><li>Mullady 2009 - 20 patien...
Anastomosis <ul><li>Revising anastomosis alone does not result in durable weight loss or maintenance </li></ul><ul><li>End...
The Pouch
Pouch Reduction Preservation of GJ Complete Revision
<ul><li>5 patients: BMI: 32 ➔ 28 </li></ul><ul><li>12 months F/U </li></ul>
<ul><li>(6) patients - mean BMI: 36.3 kg/m 2 </li></ul><ul><li>mean F/U 14 ± 9.2 months </li></ul><ul><li>Final BMI: 26.4 ...
2-year follow-up
 
Banded gastric bypass superior?
 
 
Adjustable Gastric Band <ul><li>O’brien PF, et al.  Revisional surgery for morbid obesity-conversion to the Lap Band syste...
Adjustable Gastric Band <ul><li>O’brien PF, et al.  (2/50) patients; unknown results of GBP subset </li></ul><ul><li>Kyser...
Adjustable Gastric Band <ul><li>O’brien PF, et al.  (2/50) patients; unknown results of GBP subset </li></ul><ul><li>Kyser...
The Bypass
Limb Length Studies Study Limb Length BP  Roux BMI EWL Inabnet 2005 1 year F/U 50 100 100 150 <50 NS Chobin 2002 5 year F/...
BMI > 50 kg/m 2 <ul><li>Brolin RE, Kenler HA, Gorman JG, et al.  Long-limb gastric bypass in the superobese: a prospective...
40-60 cm Roux Limb <ul><li>Bruder SJ, Freeman JB, Brazeau-Gravelle P. Lengthening the Roux–Y limb increases weight loss af...
Annals of Surgery • Volume 244, Number 5, November 2006 “ The gastric bypass limb length does not impact long-term weight ...
No correlation between limb lengths and weight loss after proximal “Fobi/Capella”
J Gastrointest Surg. 2002 Mar-Apr;6(2):195-203
66 GBP 49 D-RY 75cm common channel 12 T-RY re-stapled 5 Loop GBP standard RY (150cm Roux) 48 %EWL 51 %EWL 58.8 %EWL Annals...
 
 
<ul><li>Most revisions also included resizing the pouch along with shortening the common channel </li></ul><ul><li>Signifi...
Improvement and/or Resolution Buchwald et al. JAMA 2004; 292:1724-1737 Brolin 2008 100% 94% 92% 100% Arthritis 97% Conditi...
<ul><li>27 super-obese patients </li></ul><ul><li>EWL 30% -> 61% @ 1 year; 69% @ 5 year </li></ul><ul><li>(5) 50cm CC: (2)...
<ul><li>Weight maintenance obtainable </li></ul><ul><li>Malnutrition is unacceptable with common channel 50 cm </li></ul><...
 
Results -65 patients <ul><li>BMI: 42 kg/m 2  -> 35 kg/m 2   </li></ul><ul><li>15/65 patients (23%) developed protein-calor...
Obesity Surgery 1992 Achieved BMI 31 kg/m 2  for revisions 79% > 50% EWL
<ul><li>218 patients; mean F/U 7 years </li></ul><ul><li>serious complications: 26% </li></ul><ul><li>mortality 0.9% </li>...
“ None of the patients undergoing revision of a previous RYGB to a nonmalabsorptive RYGB achieved successful weight loss.”...
 
Conclusions <ul><li>No studies delineate the optimal Roux, biliopancreatic and common channel limb lengths. </li></ul><ul>...
Personal Experience Variable Mean ± SD Sample size (n) 212 Female:Male 64:8 Age (years) 46.6 ± 8.12 Initial BMI (kg/m 2 ) ...
Revision Procedures Group 1 Static band (Fobi/Capella) Group II Revision gastroplasty only Group III Adjustable gastric ba...
Results Performance Performance ANOVA & Bonferroni Post Hoc Tests p-value by paired T-test Variable GROUP 1 Fobi GROUP II ...
Overall Performance p-value determined by  Paired T-test % EWL prior to revision 34.4 ± 16.56 % EWL after revision 63.7 ±1...
Patient Satisfaction percent Completely satisfied 80,6% Unsatisfied 19,3% Inadequate weight loss 6,4% Weight recidivism 6,...
*Flum et al: Early mortality among Medicare beneficiaries undergoing bariatric surgical procedures. JAMA 2005;294:1903-8. ...
Complications *Higa K, Ho T, Boone K.  Laparoscopic Roux-en-Y Gastric Bypass: Technique and 3-Year Follow-Up.  J Laparosco...
Conclusions <ul><li>Laparoscopic revision of RYGBP results in significant weight loss </li></ul><ul><li>There is no differ...
Personal Approach weight recidivism abnormal anatomy revise pouch good anatomy add AGB inadequate weight loss good anatomy...
AGB after open GBP
Revise pouch (Higa)
THANK YOU
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Aspectos paar decidir una conversión

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Aspectos paar decidir una conversión

  1. 1. Revision of RYGBP (Weight loss failures) (Weight loss failures) <ul><li>Kelvin D Higa, MD, FACS, FASMBS </li></ul><ul><li>Clinical Professor in Surgery, UCSF </li></ul><ul><li>Director Bariatric and Minimally Invasive Surgery Program </li></ul><ul><li>Fresno Heart and Surgical Hospital </li></ul>10 V Congreso Internacional de Cirugia Bariatrica y Metabolica Mendoza Argentina May 19 & 20, 2011 Advanced Laparoscopic Surgery Associates Medical Group
  2. 2. Who failed whom? <ul><li>The “bad” patient </li></ul><ul><li>The “program” </li></ul><ul><li>Compliance </li></ul><ul><li>Responsibility </li></ul>
  3. 3. “ Since all types of bariatric operations can be defeated, it is virtually impossible to assign all of the “blame” for poor weight loss to the patient. Moreover, many of these patients suffer from obesity-related comorbidities and physical disability. Because morbid obesity is highly resistant to all methods of nonsurgical treatment, it seems unethical to categorically deny the opportunity for patients to have revisional surgery.” Robert Brolin WHY PERFORM REVISION SURGERY?
  4. 4. GBP considerations <ul><li>Gastric bypass is not standard - Varying pouch sizes and orientations - Variable limb lengths - Variable followup and education </li></ul><ul><li>Weight recidivism usually associated with significant psychological issues </li></ul><ul><li>Revision surgery associated with higher risk </li></ul>
  5. 5. GBP considerations <ul><li>Psychological issues can be addressed, but usually never resolved </li></ul><ul><li>Optimization of anatomy may not deliver the desired result </li></ul><ul><li>Most revision surgery associated with positive short-term, but disappointing long-term results </li></ul><ul><li>More distal; higher nutritional issues </li></ul>
  6. 6. Anatomic Optimization <ul><li>POUCH </li></ul><ul><li>ANASTOMOSIS </li></ul><ul><li>BYPASS </li></ul>
  7. 7. The Anastomosis
  8. 8. 19±9 lb 23±17 lb ±5 lb
  9. 9. <ul><li>71 patients </li></ul><ul><li>< 50% EWL or 5% weight gain after GBP </li></ul><ul><li>26 month follow-up </li></ul><ul><li>Only predictive variable was pre-endoscopy weight gain (p=0.02) </li></ul>
  10. 10. Stoma Reduction <ul><li>Spaulding L. Treatment of dilated gastrojejunostomy with sclerotherapy. Obes Surg 2003;13:254 –7 </li></ul><ul><li>Catalano MF, Rudic G, Anderson AJ, Chua TY. Weight gain after bariatric surgery as a result of large gastric stoma: endotherapy with sodium morrhuate may prevent the need for surgical revision. Gastrointest Endosc 2007;66:240 –5. </li></ul><ul><li>Herron D, Birkett D, Thompson C, Bessler M, Swanstrom L. Gastric bypass pouch and stoma reduction using a transoral endoscopic anchor placement system: A feasibility study. Surg Endosc (2008) 22:1093–1099. </li></ul>75% lost weight (6.8kg @ 6 month) 25% gained weight (3.6kg @ 6 month) 64% lost weight (22.3 ± 9.2 kg) @ 18 months
  11. 11. <ul><li>Herron D, Birkett D, Thompson C, Bessler M, Swanstrom L. Gastric bypass pouch and stoma reduction using a transoral endoscopic anchor placement system: A feasibility study. Surg Endosc (2008) 22:1093–1099. </li></ul>
  12. 12. Endoluminal <ul><li>Thompson 2006 - 8 patients; 10 kg @ 4 months Bard Endocinch </li></ul><ul><li>Mullady 2009 - 20 patients; 8.8 kg @ 3 months Rose procedure (USGI) </li></ul><ul><li>Ryou 2009 - 5 patients: 7.8 kg @ 3 months Rose procedure (USGI) </li></ul><ul><li>Mikami 2009 - 6 patients; 10 kg @ 1 year StomaphyX™ </li></ul>
  13. 13. Anastomosis <ul><li>Revising anastomosis alone does not result in durable weight loss or maintenance </li></ul><ul><li>Endoluminal interventions are still investigational; probably will not be viable revision solutions </li></ul>
  14. 14. The Pouch
  15. 15. Pouch Reduction Preservation of GJ Complete Revision
  16. 16. <ul><li>5 patients: BMI: 32 ➔ 28 </li></ul><ul><li>12 months F/U </li></ul>
  17. 17. <ul><li>(6) patients - mean BMI: 36.3 kg/m 2 </li></ul><ul><li>mean F/U 14 ± 9.2 months </li></ul><ul><li>Final BMI: 26.4 ± 4.2 kg/m 2 70.4 ± 30.4% EWL </li></ul><ul><li>No complications </li></ul>Obesity Surgery 2009
  18. 18. 2-year follow-up
  19. 20. Banded gastric bypass superior?
  20. 23. Adjustable Gastric Band <ul><li>O’brien PF, et al. Revisional surgery for morbid obesity-conversion to the Lap Band system. Obes Surg 2000;10:557-63. </li></ul><ul><li>Kyzer S, et al. Use of adjustable silicone gastric banding for revision of failed gastric bariatric operations. Obes Surg 2001;11:66-9. </li></ul><ul><li>Bessler M, et al. Adjustable gastric banding as a revisional bariatric procedure after failed gastric bypass. Obes Surg 2005;15:1443-8. </li></ul><ul><li>Gobble RM, et al. Gastric banding as a salvage procedure for patients with weight loss failure after Roux-en-Y gastric bypass. Surg Endosc 2008;22:1019-1022. </li></ul><ul><li>Chin PL, et al. Adjustable gastric band placed around gastric bypass pouch as revision operation for failed gastric bypass. SOARD 2009;5:38-42. </li></ul>
  21. 24. Adjustable Gastric Band <ul><li>O’brien PF, et al. (2/50) patients; unknown results of GBP subset </li></ul><ul><li>Kyser S, et al. (12/37) patients; unknown results of GBP subset (all revisions performed open) </li></ul>
  22. 25. Adjustable Gastric Band <ul><li>O’brien PF, et al. (2/50) patients; unknown results of GBP subset </li></ul><ul><li>Kyser S, et al. (12/37) patients; unknown results of GBP subset (all revisions performed open) </li></ul><ul><li>Bessler M, et al. (8) patients EWL 38.1±10.4% @ 1 year, 44.0±36.3% @ 2 years* </li></ul><ul><li>Gobble RM, et al. (11) patients EWL 20.8±16.9%; 13 months (2-32 months)* </li></ul><ul><li>Chin PL, et al. (8) patients EWL 24.3% @ 1 year, 36.4% @ 2 years, 66.2% @ 3 years (all surgeries were done open)* </li></ul>*No complications
  23. 26. The Bypass
  24. 27. Limb Length Studies Study Limb Length BP Roux BMI EWL Inabnet 2005 1 year F/U 50 100 100 150 <50 NS Chobin 2002 5 year F/U 30 75 150 250 <50 >50 NS MacLean 2001 4-6 year F/U 10 100 40 100 <50 >50 NS S Brolin 1992 5 year F/U 15 30 75 150 >50 S
  25. 28. BMI > 50 kg/m 2 <ul><li>Brolin RE, Kenler HA, Gorman JG, et al. Long-limb gastric bypass in the superobese: a prospective randomized study. Ann Surg. 1992; 215:387–395. </li></ul><ul><li>MacLean LD, Rhode BM, Nohr CW. Long or short-limb gastric bypass? J Gastrointest Surg. 2001;5:525–530. </li></ul><ul><li>Nelson WK , Fatima J , Houghton SG , Thompson GB , Kendrick ML , Mai JL , Kennel KA , Sarr MG . The malabsorptive very, very long limb Roux-en-Y gastric bypass for super obesity: results in 257 patients. Surgery. 2006 Oct;140(4):517-22 </li></ul>“ A subgroup of 20 patients, all of whom had a body mass index greater than 60 kg/m 2 , benefited the most from long-limb bypass.”
  26. 29. 40-60 cm Roux Limb <ul><li>Bruder SJ, Freeman JB, Brazeau-Gravelle P. Lengthening the Roux–Y limb increases weight loss after gastric bypass: a preliminary report. Obes Surg. 1991;1(1):73–7. </li></ul><ul><li>Choban PS, Flancbaum L. The effect of Roux limb lengths on outcome after Roux-en-Y gastric bypass: a prospective, randomized clinical trial. Obes Surg. 2002;12(4):540–5. </li></ul><ul><li>Fox SR, Oh KH, Fox K. Vertical banded gastroplasty and distal gastric bypass as primary procedures: a comparison. Obes Surg. 1996;6(5):421–5. </li></ul>Equivalent weight loss
  27. 30. Annals of Surgery • Volume 244, Number 5, November 2006 “ The gastric bypass limb length does not impact long-term weight loss.”
  28. 31. No correlation between limb lengths and weight loss after proximal “Fobi/Capella”
  29. 32. J Gastrointest Surg. 2002 Mar-Apr;6(2):195-203
  30. 33. 66 GBP 49 D-RY 75cm common channel 12 T-RY re-stapled 5 Loop GBP standard RY (150cm Roux) 48 %EWL 51 %EWL 58.8 %EWL Annals of Surgery • Volume 248, Number 2, August 2008 Single surgeon experience 151 patients over 22 years 55% followup @ 5 years; 28% followup @ 10 years
  31. 36. <ul><li>Most revisions also included resizing the pouch along with shortening the common channel </li></ul><ul><li>Significant medium to long term weight maintenance </li></ul><ul><li>Complication rate: 15.5% </li></ul><ul><li>Mortality: 1.5% </li></ul>
  32. 37. Improvement and/or Resolution Buchwald et al. JAMA 2004; 292:1724-1737 Brolin 2008 100% 94% 92% 100% Arthritis 97% Condition Buchwald 2004 Diabetes 84% Hypertension 75% Hyperlipidemia 94% Sleep Apnea 87%
  33. 38. <ul><li>27 super-obese patients </li></ul><ul><li>EWL 30% -> 61% @ 1 year; 69% @ 5 year </li></ul><ul><li>(5) 50cm CC: (2) died of hepatic failure; all revised for malnutrition </li></ul><ul><li>(22) 150 cm CC: (3) revised for malnutrition </li></ul>Journal of GastrointestinalSurgery 1997
  34. 39. <ul><li>Weight maintenance obtainable </li></ul><ul><li>Malnutrition is unacceptable with common channel 50 cm </li></ul><ul><li>“Adding malabsorption to restriction...” </li></ul>Journal of GastrointestinalSurgery 1997
  35. 41. Results -65 patients <ul><li>BMI: 42 kg/m 2 -> 35 kg/m 2 </li></ul><ul><li>15/65 patients (23%) developed protein-calorie malnutrition </li></ul><ul><li>6 patients ultimately required re-revision to S-FPO </li></ul>
  36. 42. Obesity Surgery 1992 Achieved BMI 31 kg/m 2 for revisions 79% > 50% EWL
  37. 43. <ul><li>218 patients; mean F/U 7 years </li></ul><ul><li>serious complications: 26% </li></ul><ul><li>mortality 0.9% </li></ul>
  38. 44. “ None of the patients undergoing revision of a previous RYGB to a nonmalabsorptive RYGB achieved successful weight loss.” Standard Distal weight loss 68 ± 7 lb 115 ± 12 lb p < .001 satisfaction 78% 90% NS > 50% EWL 45% 52% NS
  39. 46. Conclusions <ul><li>No studies delineate the optimal Roux, biliopancreatic and common channel limb lengths. </li></ul><ul><li>There may be a long term effect on BMI > 50 kg/m 2 with additional nutritional concerns </li></ul><ul><li>Long-term data (>10 years) inconclusive </li></ul>
  40. 47. Personal Experience Variable Mean ± SD Sample size (n) 212 Female:Male 64:8 Age (years) 46.6 ± 8.12 Initial BMI (kg/m 2 ) prior to first RYGBP 53.2 ± 11.4 BMI (kg/m 2 ) @ time of revision 41.6 ± 7.7 % EWL prior to revision 32.5 ± 20.5 Mean time to revision (years) 8.4 ± 4.59 Advanced Laparoscopic Surgery Associates Medical Group
  41. 48. Revision Procedures Group 1 Static band (Fobi/Capella) Group II Revision gastroplasty only Group III Adjustable gastric band Group IV Distal ➔ proximal gastric bypass & revision gastroplasty Group V Distal gastric bypass Advanced Laparoscopic Surgery Associates Medical Group
  42. 49. Results Performance Performance ANOVA & Bonferroni Post Hoc Tests p-value by paired T-test Variable GROUP 1 Fobi GROUP II Revision only GROUP III AGB GROUP IV Distal -> Prox GROUP V Distal TOTAL p-value Followup (years) 2.3 ± 0.96 3.0 ± 2.16 1.3 ± 0.44 3.4 ± 2.13 2.6 ± 0.98 2.6 ± 1.70 NS % EWL before revision 35.4 ± 19.56 32.3 ± 14.66 43.7 ± 11.06 31.2 ± 14.85 40.8 ± 12.86 34.4 ± 16.56 NS % EWL after revision 63.5 ± 17.28 62.2 ± 20.25 60.0 ± 24.79 73.4 ± 25.74 62.0 ± 21.36 63.7 ± 19.62 NS Absolute % EWL 28.1 ± 15.71 29.9 ± 12.02 16.3 ± 14.01 42.2 ± 32.4 21.2 ± 16.06 29.3 ± 16.85 NS p-value < 0.001 < 0.001 < 0.001 < 0.040 < 0.001 < 0.001 Advanced Laparoscopic Surgery Associates Medical Group (5) removed
  43. 50. Overall Performance p-value determined by Paired T-test % EWL prior to revision 34.4 ± 16.56 % EWL after revision 63.7 ±19.62 Absolute % EWL 29.3 ± 16.85 p-value < 0.001 BMI prior to revision 41.6 ± 7.74 BMI after revision 34.9 ± 7.32 Absolute change in BMI 6.7 ± 7.53 p-value < 0.001 Advanced Laparoscopic Surgery Associates Medical Group
  44. 51. Patient Satisfaction percent Completely satisfied 80,6% Unsatisfied 19,3% Inadequate weight loss 6,4% Weight recidivism 6,4% Unrealized expectations 6,4% Advanced Laparoscopic Surgery Associates Medical Group
  45. 52. *Flum et al: Early mortality among Medicare beneficiaries undergoing bariatric surgical procedures. JAMA 2005;294:1903-8. Higa K, Ho T, Boone K. Laparoscopic Roux-en-Y gastric bypass: technique and 3-year follow-up. J Laparoscopic & Adv Surg Tech 2001, 11: 377-382 1.9% Mortality among MCARE pts* 0.8% 0 1.4% Brolin Higa-VBG Higa-GBP Higa-Primary Morbidity 21,8% 46,6% 26% 14,8% Mortality 1,3% 0,2%
  46. 53. Complications *Higa K, Ho T, Boone K. Laparoscopic Roux-en-Y Gastric Bypass: Technique and 3-Year Follow-Up. J Laparoscopic & Adv Surg Tech 2001, 11: 377-382. Advanced Laparoscopic Surgery Associates Medical Group Primary* Brolin Higa Stenosis 4,9% 2% 6% Leaks 0,7% 6% 9,5% Hemorrhage 0,8% NR 2,4%
  47. 54. Conclusions <ul><li>Laparoscopic revision of RYGBP results in significant weight loss </li></ul><ul><li>There is no difference between groups as far as performance or overall complications </li></ul><ul><li>Most patients are very satisfied after revision </li></ul><ul><li>Complication rates are high: 26% </li></ul>Advanced Laparoscopic Surgery Associates Medical Group
  48. 55. Personal Approach weight recidivism abnormal anatomy revise pouch good anatomy add AGB inadequate weight loss good anatomy satiety no surgery poor nutrition good nutrition distal bypass (if compliant) reversal
  49. 56. AGB after open GBP
  50. 57. Revise pouch (Higa)
  51. 58. THANK YOU

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