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Rahul Tiwari1,*
, Philip Mathew2
, Yasmin Jose3
, Bhaskar Roy4
, Kritika Sehrawat5
1
Fellow, 2
HOD, 3
Clinical Observer, 4,5
PG Student, 1-3
Jubilee Mission Medical College Hospital and Research Center,
Thrissur, Kerala, 4
KVG Dental College and Hospital, Sullia, D.K, Karnataka, 5
Sudha Rustagi Dental College and Research
Centre, Faridabad, Haryana, India
*Corresponding Author:
Email: drrahulvctiwari@gmail.com
The most widely recognized difficulty of a repaired congenital fissure is palatal fistula which can be seen from narrow to wide
forms as derived in the published literature. Small fistulas are usually asymptomatic, but the larger ones create regurgitation of
fluids in the nasal cavity and interferes the normal speech. Various options are present for the surgical management to close
fistulas. Local flaps are usually used for small fistulas comparatively large fistulas are difficult to manage. Tongue flaps due to its
high vascularity are region is the treatment of choice for most of the surgeons. The anteriorly based tongue fold is a sheltered and
compelling strategy for conclusion of moderately extensive repetitive palatal fistula with no practical impedance of the giver site.
This article portrays remaking of one such wide palatal fistula by anteriorly based tongue fold performing single layer
conclusion.
Keywords: Palatal fistula, Tongue flap, Cleft palate, Local flap.
0 – 77.8% worldwide prevalence is proven as the
commonest complication occurring after cleft palate is
palatal fistula.1
Palatal fistulas can involve both primary
and secondary palate in which involvement of
secondary palate ranges from 8.9 – 34%.2
Transposition
of adjacent tissues can be used for closing small fistulas
comparatively it is extremely difficult to close large
fistulas.3-8
The junction premaxilla and secondary palate
or hard and soft palate is the common location of
palatal fistula. Size, position and degree of
velopharyngeal incompetence are major factors for
deciding the treatment plan. The incidence of fistulas is
not necessarily of genetic origin but the etiologic
factors can also vary like trauma, tumour, infection,
granuloma, leprosy, Noma, syphilitic gumma,
leishmaniasis.2
Main objectives of ideal reconstruction
are replacement of the lost tissue with similar tissue.
Tongue flap is a versatile flap which can be anteriorly
or posteriorly based with axial or random pattern of
blood supply and can be harvested from ventral, dorsal
or lateral portion of tongue.9-12
In the event of tongue
folds there are numerous specialized focuses that
specialists need to consider as the essential to diminish
the odds of repeat. One of these is the accentuation on
great nasal layer conclusion in two-layer system.13-16
Seven-year-old girl operated for cleft lip and palate
at childhood presented with huge palatal fistula on
primary palate extending mildly to secondary palate
presented to us for closure (Fig. 1). An anteriorly based
tongue fold was made arrangements for the conclusion
of palatal fistula. Choice was made to play out a
solitary layer conclusion. The palatal fistula was
roughly quadrangular in shape each side measuring
around 3 cm crossing alveolus between the incisors.
Orthopantomogram and 3-D CT confirmed the bony
defect. Routine blood investigations were done which
were unremarkable. Under general anaesthesia,
according to the size of defect (Fig. 2) an anteriorly
based tongue flap was taken which was sutured with
vicryl (non-absorbable) (Fig. 3). Length and width of
tongue flap was determined by using a template as a
guide. The depth of flap was about 5 to 8 mm thick,
which included thin muscular layer, for the protection
of sub-mucosal plexus, which is the major source of
blood supply to the flap. The flap was then rotated
forward and sutured to raw edges of palatal defect
anteriorly and laterally using 4-0 vicryl. Donor site was
also closed using interrupted 4-0 vicryl sutures. We
used a thin needle prick after an hour of procedure then
every 4 hourly for a period of 24 hours to check the
viability of flap. The flap was tested with vascular loop
tourniquet for adequate vascularity before separation.
Patient was given nasal feed post operatively for two
weeks. Following fourteen long periods of medical
procedure the pedicle was separated under general
anaesthesia (Fig. 4). Palatable recuperating of the site
was watched. Follow up revealed no nasal regurgitation
and mild improvement of speech and the patient was
sent to speech pathologist.
Fig. 1: Pre-Clinical Picture showing Cleft
Fig. 2: Measurement of defect
Fig. 3: Anterior tongue flap
Fig. 4: Post-operative picture
Guerrero-Santos and Altamirano (1966) were first
to describe the use of a tongue flap to close palatal
fistulas secondary to cleft palate repair. The tongue
flap, with its muscular bulk and excellent vascularity,
has proved to be effective in occluding even large
palatal fistulas that were previously felt to be
inoperable. Tongue fold have been utilized as a part of
abundant in our field of oral and maxillofacial medical
procedure to close innate deformities like palatal fistula
or obtained absconds which happen after delicate tissue
tumor resection, injury, diseases or oro-antral fistulas.
They have been additionally utilized for conclusion of
imperfections happening after radiotherapy absconds.
There is posteriorly based fold too which are shown for
recreation of delicate sense of taste, back oral mucosa
and retromolar region. Anteriorly based folds are
utilized to close hard sense of taste, essential sense of
taste, intra oral mucosa, lips and floor of the mouth
absconds. They are adaptable decision of treatment
because of their vascularity, portability and versatility.
Tongue folds are shown in instances of palatal fistulas,
its repeat, disappointment of congenital fissure, sense of
taste with extreme scarring and places here lingering
palatal tissue does not permit reasonable conclusion.
They are likewise utilized as a part of deformities
which are bigger than 1 cm. in width. Achievement has
been accounted for in nearby folds in fistulas estimating
under 1.5 cm. in breadth.17
Ranina supply routes
navigate profoundly before ventral mucosa, creating
branches which rise to the dorsum of tongue, this ranina
branches inundate front based tongue fold.18
Several
creators have announced occurrence of enormous
palatal fistula after palatoplasties, and additionally
trouble of their treatment. Occurrence have extended
from 0-30% which relies upon kind of parted, patients
age, palatoplasty procedure and specialists encounter.19
Tongue flap closure for end stage palatal defect id
associated with relative lack of complication and high
success rate in children and adults.20
The specialist
must not delay to raise a vast fold to guarantee its
vascular practicality and permit impressive tongue
development without undue strain on the pedicle.21
This
allows water tight closure and increased area for
ingrowth of new blood vessels before flap division.
Some hesitate to alter the tongue anatomy for fear of
changing speech and deglutination. There are no
significant adverse effect on articulation, lingual
mobility, or swallowing following the use of a tongue
flap procedure to close palatal defects. The mobility of
the remaining tongue may be more important in
preserving speech intelligibility than the relative mass
of the tongue that remains. Although lingual mobility
and articulation are reported to be unaffected by
removal of tongue tissue, Steinhauser (1982) cautioned
that the tongue flap itself may interfere with lingual
mobility and articulation if it is too thick. In this case,
partial excision or debulking may be required as a
secondary procedure. The tongue flap has been found to
be an effective method of closing large palatal fistulas
to reduce nasal emission and hypernasality. However,
there is a lack of sufficient clinical research that
specifically evaluates changes in resonance and nasal
emission as a result of fistula repair. Protruding tissue
can interfere with normal tongue movement, with
tongue placement, and with the anterior f ow of air
during articulation. This can result in a lateral distortion
of speech. Therefore, the surgeon should attempt to
shape the tongue flap so that it conforms to the contour
of the palatal vault as much as possible. Occluding a
palatal fistula is often done for the purpose of reducing
or eliminating hypernasality and nasal emission. The
nasal emission that remains is more audible and,
therefore, the patient's speech may be perceived to be
worse. If this occurs, parents should be counseled that
this is not a sign that the surgery was unsuccessful.19
Few authors have used flap from lateral border of
tongue. Different alterations have been done in these
folds in which one adjusted fold strategy shows that the
edges of fistula are swung to the nasal side without
coordinate conclusion, leaving the nasal layer free of
strain. In the wake of resecting the fold, the all around
vascularized crude territory of tongue will be in contact
with the crude region of fistula and nasal hole. This
crude to crude contact coordinates the tongue fold and
prompts firm recuperating of the encompassing region.
The nasal layer hole will then begin to epithelialize
until the total conclusion of this hole which is
demonstrated by nasoscope development.22
Single layer
conclusion of fistula by pedicle foremost based tongue
fold can hence be demonstrated for repair of extensive
palatal fistulas that can't be effectively treated by other
nearby and removed folds as a result of the size and
position of the imperfections.
Tongue folds are amazing option for wide or
intermittent palatal fistulas as they are adaptable and
can be intended for every fistula closure. They are
normally shown for fistulas that are in excess of 1 cm.
The pedicle anteriorly based tongue flap in our case has
given excellent result which has improved the quality of
life of the patient.
1. Hardwicke JT, Landini G, Richard BM. Fistula incidence
after primary cleft palate repair: a systematic review of
the literature. Plast Reconstr Surg 2014;134:618e–627e.
2. Posnick JC, Getz SB Jr. Surgical closure of end-stage
palatal fistulas using anteriorly-based dorsal tongue flaps.
J Oral Maxillofac Surg 1987;45:907-12.
3. Campbell R. Fistula in the hard palate following
cleftpalate surgery. Br J Plast Surg 1962;15:377.
4. Guzel MZ, Altintas F. Repair of large, anterior
palatalfistulas using thin tongue flaps: long-term follow-
up of 10patients. Ann Plast Surg 2000;45:109-14.
5. Millard RD. Cleft craft-the evolution of its surgery vol
III—alveolar & palatal deformities. Little Brown & Co.,
Boston. 1980;809-94.
6. Visscher SH, van Minnen B, Bos RRM. Closure of
oroantral communications: a review of literature. J Oral
Maxillofac Surg 2010;68:1384-91.
7. Murthy J. Descriptive study of management of palatal
fistula in one hundred and ninety-four cleft individuals.
Indian J Plast Surg 2011;44:41-6.
8. Bénateau H, Traoré H, Gilliot B, Taupin A, Ory L,
GuillouJamard MR, et al. Repair of palatal fistulae in
cleft patients. Rev Stomatol Chir Maxillofac
2011;112:139-44
9. Al-Qattan MM. A modified technique of using the tongue
tip for closure of large anterior palatal fistula. Ann Plast
Surg 2001;47:458-60.
10. Posnick JC, Getz SB., Jr Surgical closure of end-stage
palatal fistulas using anteriorly-based dorsal tongue flaps.
J Oral Maxillofac Surg 1987;45:907-12.
11. Bütow KW, Duvenage JG. Pedicled ―flap‖ from a
tongue flap. Int J Oral Maxillofac Surg. 1986;15:581-4.
12. Ceran C, Demirseren ME, Sarici M, Durgun M, Tekin F.
Tongue flap as a reconstructive option in intraoral
defects. J Craniofac Surg 2013;24:972-4.
13. Sadhu P. Oronasal fistula in cleft palate surgery. Ind J
Plast Surg 2009;42 Suppl:S123–8.
14. Vasishta SM, Krishnan G, Rai YS, et al. The versatility of
the tongue flap in the closure of palatal fistula.
Craniomaxillofac Trauma Reconstr 2012;5:145–60.
15. Sodhi SP, Kapoor P, Kapoor D. Closure of anterior
palatal fistula by tongue flap: A prospective study. J
Maxillofac Oral Surg 2014;13:546–9.
16. Diah E, Lo LJ, Yun C, et al. Cleft oronasal fistula: a
review of treatment results and a surgical management
algorithm proposal. Chang Gung Med J 2007;30:529–
537.
17. Zeidman A, Lockshin A et al. Repair of a chronic
oronasal defect with an anterior based tongue flap: report
of a case. J Oral Maxillofac Surg 1988;46:412-5.
18. Whetzel TP, Saunders CJ. Arterial anatomy of the oral
cavity: An analysis of vascular territories. Plast Reconstr
Surg 1997;100(3):582-7.
19. Cohen SR, Kalinowski J, La Rossa D, Randall P. Cleft
palate fistulas: a multivariate statistical analysis of a
prevalence, etiology and surgical management. Plast
Reconstr Surg 1991;87 (6):1041-7.
20. Posnick JC, Getz SB Jr (1987) Surgical closure of end
stage palatal fistulas using anteriorly based dorsal tongue
flaps. J Oral Maxillofac Surg 45(11):907–12
21. Smith DM, Vecchione L, Jiang S, et al. The Pittsburgh
Fistula Classification System: a standardized scheme for
the description of palatal fistulas. Cleft Palate Craniofac
J 2007;44:590–4.
22. Alsalman AK, Algadiem EA, Alwabari MS, Almugarrab
FJ. Single-layer Closure with Tongue Flap for Palatal
Fistula in Cleft Palate Patients. Plastic and
Reconstructive Surg 2016;4(8):e852.

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18th publication JOOO- 1st Name.pdf

  • 1. Rahul Tiwari1,* , Philip Mathew2 , Yasmin Jose3 , Bhaskar Roy4 , Kritika Sehrawat5 1 Fellow, 2 HOD, 3 Clinical Observer, 4,5 PG Student, 1-3 Jubilee Mission Medical College Hospital and Research Center, Thrissur, Kerala, 4 KVG Dental College and Hospital, Sullia, D.K, Karnataka, 5 Sudha Rustagi Dental College and Research Centre, Faridabad, Haryana, India *Corresponding Author: Email: drrahulvctiwari@gmail.com The most widely recognized difficulty of a repaired congenital fissure is palatal fistula which can be seen from narrow to wide forms as derived in the published literature. Small fistulas are usually asymptomatic, but the larger ones create regurgitation of fluids in the nasal cavity and interferes the normal speech. Various options are present for the surgical management to close fistulas. Local flaps are usually used for small fistulas comparatively large fistulas are difficult to manage. Tongue flaps due to its high vascularity are region is the treatment of choice for most of the surgeons. The anteriorly based tongue fold is a sheltered and compelling strategy for conclusion of moderately extensive repetitive palatal fistula with no practical impedance of the giver site. This article portrays remaking of one such wide palatal fistula by anteriorly based tongue fold performing single layer conclusion. Keywords: Palatal fistula, Tongue flap, Cleft palate, Local flap. 0 – 77.8% worldwide prevalence is proven as the commonest complication occurring after cleft palate is palatal fistula.1 Palatal fistulas can involve both primary and secondary palate in which involvement of secondary palate ranges from 8.9 – 34%.2 Transposition of adjacent tissues can be used for closing small fistulas comparatively it is extremely difficult to close large fistulas.3-8 The junction premaxilla and secondary palate or hard and soft palate is the common location of palatal fistula. Size, position and degree of velopharyngeal incompetence are major factors for deciding the treatment plan. The incidence of fistulas is not necessarily of genetic origin but the etiologic factors can also vary like trauma, tumour, infection, granuloma, leprosy, Noma, syphilitic gumma, leishmaniasis.2 Main objectives of ideal reconstruction are replacement of the lost tissue with similar tissue. Tongue flap is a versatile flap which can be anteriorly or posteriorly based with axial or random pattern of blood supply and can be harvested from ventral, dorsal or lateral portion of tongue.9-12 In the event of tongue folds there are numerous specialized focuses that specialists need to consider as the essential to diminish the odds of repeat. One of these is the accentuation on great nasal layer conclusion in two-layer system.13-16 Seven-year-old girl operated for cleft lip and palate at childhood presented with huge palatal fistula on primary palate extending mildly to secondary palate presented to us for closure (Fig. 1). An anteriorly based tongue fold was made arrangements for the conclusion of palatal fistula. Choice was made to play out a solitary layer conclusion. The palatal fistula was roughly quadrangular in shape each side measuring around 3 cm crossing alveolus between the incisors. Orthopantomogram and 3-D CT confirmed the bony defect. Routine blood investigations were done which were unremarkable. Under general anaesthesia, according to the size of defect (Fig. 2) an anteriorly based tongue flap was taken which was sutured with vicryl (non-absorbable) (Fig. 3). Length and width of tongue flap was determined by using a template as a guide. The depth of flap was about 5 to 8 mm thick, which included thin muscular layer, for the protection of sub-mucosal plexus, which is the major source of blood supply to the flap. The flap was then rotated forward and sutured to raw edges of palatal defect anteriorly and laterally using 4-0 vicryl. Donor site was also closed using interrupted 4-0 vicryl sutures. We used a thin needle prick after an hour of procedure then every 4 hourly for a period of 24 hours to check the viability of flap. The flap was tested with vascular loop tourniquet for adequate vascularity before separation. Patient was given nasal feed post operatively for two weeks. Following fourteen long periods of medical procedure the pedicle was separated under general anaesthesia (Fig. 4). Palatable recuperating of the site was watched. Follow up revealed no nasal regurgitation and mild improvement of speech and the patient was sent to speech pathologist.
  • 2. Fig. 1: Pre-Clinical Picture showing Cleft Fig. 2: Measurement of defect Fig. 3: Anterior tongue flap Fig. 4: Post-operative picture Guerrero-Santos and Altamirano (1966) were first to describe the use of a tongue flap to close palatal fistulas secondary to cleft palate repair. The tongue flap, with its muscular bulk and excellent vascularity, has proved to be effective in occluding even large palatal fistulas that were previously felt to be inoperable. Tongue fold have been utilized as a part of abundant in our field of oral and maxillofacial medical procedure to close innate deformities like palatal fistula or obtained absconds which happen after delicate tissue tumor resection, injury, diseases or oro-antral fistulas. They have been additionally utilized for conclusion of imperfections happening after radiotherapy absconds. There is posteriorly based fold too which are shown for recreation of delicate sense of taste, back oral mucosa and retromolar region. Anteriorly based folds are utilized to close hard sense of taste, essential sense of taste, intra oral mucosa, lips and floor of the mouth absconds. They are adaptable decision of treatment because of their vascularity, portability and versatility. Tongue folds are shown in instances of palatal fistulas, its repeat, disappointment of congenital fissure, sense of taste with extreme scarring and places here lingering palatal tissue does not permit reasonable conclusion. They are likewise utilized as a part of deformities which are bigger than 1 cm. in width. Achievement has been accounted for in nearby folds in fistulas estimating under 1.5 cm. in breadth.17 Ranina supply routes navigate profoundly before ventral mucosa, creating branches which rise to the dorsum of tongue, this ranina branches inundate front based tongue fold.18 Several creators have announced occurrence of enormous palatal fistula after palatoplasties, and additionally trouble of their treatment. Occurrence have extended from 0-30% which relies upon kind of parted, patients age, palatoplasty procedure and specialists encounter.19 Tongue flap closure for end stage palatal defect id associated with relative lack of complication and high success rate in children and adults.20 The specialist must not delay to raise a vast fold to guarantee its vascular practicality and permit impressive tongue development without undue strain on the pedicle.21 This allows water tight closure and increased area for ingrowth of new blood vessels before flap division. Some hesitate to alter the tongue anatomy for fear of changing speech and deglutination. There are no significant adverse effect on articulation, lingual mobility, or swallowing following the use of a tongue flap procedure to close palatal defects. The mobility of the remaining tongue may be more important in preserving speech intelligibility than the relative mass of the tongue that remains. Although lingual mobility and articulation are reported to be unaffected by removal of tongue tissue, Steinhauser (1982) cautioned that the tongue flap itself may interfere with lingual mobility and articulation if it is too thick. In this case, partial excision or debulking may be required as a secondary procedure. The tongue flap has been found to be an effective method of closing large palatal fistulas to reduce nasal emission and hypernasality. However, there is a lack of sufficient clinical research that specifically evaluates changes in resonance and nasal
  • 3. emission as a result of fistula repair. Protruding tissue can interfere with normal tongue movement, with tongue placement, and with the anterior f ow of air during articulation. This can result in a lateral distortion of speech. Therefore, the surgeon should attempt to shape the tongue flap so that it conforms to the contour of the palatal vault as much as possible. Occluding a palatal fistula is often done for the purpose of reducing or eliminating hypernasality and nasal emission. The nasal emission that remains is more audible and, therefore, the patient's speech may be perceived to be worse. If this occurs, parents should be counseled that this is not a sign that the surgery was unsuccessful.19 Few authors have used flap from lateral border of tongue. Different alterations have been done in these folds in which one adjusted fold strategy shows that the edges of fistula are swung to the nasal side without coordinate conclusion, leaving the nasal layer free of strain. In the wake of resecting the fold, the all around vascularized crude territory of tongue will be in contact with the crude region of fistula and nasal hole. This crude to crude contact coordinates the tongue fold and prompts firm recuperating of the encompassing region. The nasal layer hole will then begin to epithelialize until the total conclusion of this hole which is demonstrated by nasoscope development.22 Single layer conclusion of fistula by pedicle foremost based tongue fold can hence be demonstrated for repair of extensive palatal fistulas that can't be effectively treated by other nearby and removed folds as a result of the size and position of the imperfections. Tongue folds are amazing option for wide or intermittent palatal fistulas as they are adaptable and can be intended for every fistula closure. They are normally shown for fistulas that are in excess of 1 cm. The pedicle anteriorly based tongue flap in our case has given excellent result which has improved the quality of life of the patient. 1. Hardwicke JT, Landini G, Richard BM. Fistula incidence after primary cleft palate repair: a systematic review of the literature. Plast Reconstr Surg 2014;134:618e–627e. 2. Posnick JC, Getz SB Jr. Surgical closure of end-stage palatal fistulas using anteriorly-based dorsal tongue flaps. J Oral Maxillofac Surg 1987;45:907-12. 3. Campbell R. Fistula in the hard palate following cleftpalate surgery. Br J Plast Surg 1962;15:377. 4. Guzel MZ, Altintas F. Repair of large, anterior palatalfistulas using thin tongue flaps: long-term follow- up of 10patients. Ann Plast Surg 2000;45:109-14. 5. Millard RD. Cleft craft-the evolution of its surgery vol III—alveolar & palatal deformities. Little Brown & Co., Boston. 1980;809-94. 6. Visscher SH, van Minnen B, Bos RRM. Closure of oroantral communications: a review of literature. J Oral Maxillofac Surg 2010;68:1384-91. 7. Murthy J. Descriptive study of management of palatal fistula in one hundred and ninety-four cleft individuals. Indian J Plast Surg 2011;44:41-6. 8. Bénateau H, Traoré H, Gilliot B, Taupin A, Ory L, GuillouJamard MR, et al. Repair of palatal fistulae in cleft patients. Rev Stomatol Chir Maxillofac 2011;112:139-44 9. Al-Qattan MM. A modified technique of using the tongue tip for closure of large anterior palatal fistula. Ann Plast Surg 2001;47:458-60. 10. Posnick JC, Getz SB., Jr Surgical closure of end-stage palatal fistulas using anteriorly-based dorsal tongue flaps. J Oral Maxillofac Surg 1987;45:907-12. 11. Bütow KW, Duvenage JG. Pedicled ―flap‖ from a tongue flap. Int J Oral Maxillofac Surg. 1986;15:581-4. 12. Ceran C, Demirseren ME, Sarici M, Durgun M, Tekin F. Tongue flap as a reconstructive option in intraoral defects. J Craniofac Surg 2013;24:972-4. 13. Sadhu P. Oronasal fistula in cleft palate surgery. Ind J Plast Surg 2009;42 Suppl:S123–8. 14. Vasishta SM, Krishnan G, Rai YS, et al. The versatility of the tongue flap in the closure of palatal fistula. Craniomaxillofac Trauma Reconstr 2012;5:145–60. 15. Sodhi SP, Kapoor P, Kapoor D. Closure of anterior palatal fistula by tongue flap: A prospective study. J Maxillofac Oral Surg 2014;13:546–9. 16. Diah E, Lo LJ, Yun C, et al. Cleft oronasal fistula: a review of treatment results and a surgical management algorithm proposal. Chang Gung Med J 2007;30:529– 537. 17. Zeidman A, Lockshin A et al. Repair of a chronic oronasal defect with an anterior based tongue flap: report of a case. J Oral Maxillofac Surg 1988;46:412-5. 18. Whetzel TP, Saunders CJ. Arterial anatomy of the oral cavity: An analysis of vascular territories. Plast Reconstr Surg 1997;100(3):582-7. 19. Cohen SR, Kalinowski J, La Rossa D, Randall P. Cleft palate fistulas: a multivariate statistical analysis of a prevalence, etiology and surgical management. Plast Reconstr Surg 1991;87 (6):1041-7. 20. Posnick JC, Getz SB Jr (1987) Surgical closure of end stage palatal fistulas using anteriorly based dorsal tongue flaps. J Oral Maxillofac Surg 45(11):907–12 21. Smith DM, Vecchione L, Jiang S, et al. The Pittsburgh Fistula Classification System: a standardized scheme for the description of palatal fistulas. Cleft Palate Craniofac J 2007;44:590–4. 22. Alsalman AK, Algadiem EA, Alwabari MS, Almugarrab FJ. Single-layer Closure with Tongue Flap for Palatal Fistula in Cleft Palate Patients. Plastic and Reconstructive Surg 2016;4(8):e852.