Sequence of Events in Acute inflammation with significance

1. Acute inflammation
Presented by Dr Akhil S
Malabar Dental Collge
Department of oral pathology

7. Main components of acute inflammation
• Vascular events
• Cellular events.
The vascular event is again divided in to vasodilatation and increased
vascular permeability.

10. Mechanisms causing increased vascular permeability
• Endothelial contraction
• Cytoskeleton changes
• Leucocyte damage

11. • Cellular events

12. Leucocyte recruitment
Steps
Margination, Adhesion to endothelium and rolling
Firm adhesion to endothelium
Transmigration between endothelial cells
Migration in interstitial tissues to a chemotactic stimulus

14. How leucocyte move towards the bacteria
By
Bacterial products
Cytokines
Components of complement system
Products of lipooxygenase pathway

15. Neutrophil Crawling on a Glass Slide

16. • Phagocytosis
• Production of opsonins
• amplification

18. refernces
• Robbins Basic pathology by kumar
• Boyd’s text book of pathology
• Text book of pathology –Harsh mohan