Unsatisfactory 0.00% 2 Less Than Satisfactory 65.00% 3 Satisfactory 75.00% 4 Good 85.00% 5 Excellent 100.00% 70.0 %Content 40.0 %Identification, analysis, and discussion of the components of a valid evidence-based research study, and how a healthcare leader has used such studies to drive change Failure to demonstrate the ability to identify and analyze the components of the study. Failure to demonstrate understanding of how a healthcare leader has used similar studies to drive change. Demonstrates only minimal ability to identify and analyze the components of the study. Demonstrates only minimal understanding of how a healthcare leader has used similar studies to drive change. Demonstrates ability to identify and analyze components of a study, but has some slight misunderstanding of the implications and meaning. Provides a basic understanding of how a healthcare leader has used similar studies to drive change. Demonstrates ability to identify and analyze components of a study (in student's own words). Understands the ways a healthcare leader has used such studies to drive change. Describes clearly all of the components of a valid evidence-based research study (in student's own words). Clearly describes a thorough understanding of how a healthcare leader has used such studies to drive change, and gives specific examples. 30.0 %Integration of information from outside resources into the body of paper No references, examples, or explanations. Provides some supporting examples, but minimal explanations and no published references. Supports main points with examples and explanations, but fails to include published references to support claims and ideas. Supports main points with references, explanations, and examples. Analysis and description is direct, competent, and appropriate of the criteria. Supports main points with references, examples, and full explanations of how they apply. Thoughtfully analyzes, evaluates, and describes major points of the criteria. 20.0 %Organization and Effectiveness 7.0 %Assignment Development and Purpose Paper lacks any discernible overall purpose or organizing claim. Thesis and/or main claim are insufficiently developed and/or vague; purpose is not clear. Thesis and/or main claim are apparent and appropriate to purpose. Thesis and/or main claim are clear and forecast the development of the paper. It is descriptive and reflective of the arguments and appropriate to the purpose. Thesis and/or main claim are comprehensive. The essence of the paper is contained within the thesis. Thesis statement makes the purpose of the paper clear. 8.0 %Argument Logic and Construction Statement of purpose is not justified by the conclusion. The conclusion does not support the claim made. Argument is incoherent and uses noncredible sources. Sufficient justification of claims is lacking. Argument lacks consistent unity. There are obvious flaws in the logic. Some sources have questionable credibility. Argument is orderly, but may ha ...

1. Unsatisfactory
0.00%
2
Less Than Satisfactory
65.00%
3
Satisfactory
75.00%
4
Good
85.00%
5
Excellent
100.00%
70.0 %Content
40.0 %Identification, analysis, and discussion of the
components of a valid evidence-based research study, and how a
healthcare leader has used such studies to drive change
Failure to demonstrate the ability to identify and analyze the
components of the study. Failure to demonstrate understanding
of how a healthcare leader has used similar studies to drive
change.
Demonstrates only minimal ability to identify and analyze the
components of the study. Demonstrates only minimal
understanding of how a healthcare leader has used similar
studies to drive change.
Demonstrates ability to identify and analyze components of a
study, but has some slight misunderstanding of the implications
and meaning. Provides a basic understanding of how a
healthcare leader has used similar studies to drive change.
Demonstrates ability to identify and analyze components of a
study (in student's own words). Understands the ways a
healthcare leader has used such studies to drive change.

2. Describes clearly all of the components of a valid evidence-
based research study (in student's own words). Clearly describes
a thorough understanding of how a healthcare leader has used
such studies to drive change, and gives specific examples.
30.0 %Integration of information from outside resources into
the body of paper
No references, examples, or explanations.
Provides some supporting examples, but minimal explanations
and no published references.
Supports main points with examples and explanations, but fails
to include published references to support claims and ideas.
Supports main points with references, explanations, and
examples. Analysis and description is direct, competent, and
appropriate of the criteria.
Supports main points with references, examples, and full
explanations of how they apply. Thoughtfully analyzes,
evaluates, and describes major points of the criteria.
20.0 %Organization and Effectiveness
7.0 %Assignment Development and Purpose
Paper lacks any discernible overall purpose or organizing claim.
Thesis and/or main claim are insufficiently developed and/or
vague; purpose is not clear.
Thesis and/or main claim are apparent and appropriate to
purpose.
Thesis and/or main claim are clear and forecast the development
of the paper. It is descriptive and reflective of the arguments
and appropriate to the purpose.
Thesis and/or main claim are comprehensive. The essence of the
paper is contained within the thesis. Thesis statement makes the
purpose of the paper clear.
8.0 %Argument Logic and Construction
Statement of purpose is not justified by the conclusion. The

3. conclusion does not support the claim made. Argument is
incoherent and uses noncredible sources.
Sufficient justification of claims is lacking. Argument lacks
consistent unity. There are obvious flaws in the logic. Some
sources have questionable credibility.
Argument is orderly, but may have a few inconsistencies. The
argument presents minimal justification of claims. Argument
logically, but not thoroughly, supports the purpose. Sources
used are credible. Introduction and conclusion bracket the
thesis.
Argument shows logical progression. Techniques of
argumentation are evident. There is a smooth progression of
claims from introduction to conclusion. Most sources are
authoritative.
Clear and convincing argument presents a persuasive claim in a
distinctive and compelling manner. All sources are
authoritative.
5.0 %Mechanics of Writing (includes spelling, punctuation,
grammar, language use)
Surface errors are pervasive enough that they impede
communication of meaning. Inappropriate word choice and/or
sentence construction are used.
Frequent and repetitive mechanical errors distract the reader.
Inconsistencies in language choice (register), sentence
structure, and/or word choice are present.
Some mechanical errors or typos are present, but are not overly
distracting to the reader. Correct sentence structure and
audience-appropriate language are used.
Prose is largely free of mechanical errors, although a few may
be present. A variety of sentence structures and effective
figures of speech are used.
Writer is clearly in command of standard, written, academic
English.
10.0 %Format

4. 5.0 %Paper Format (Use of appropriate style for the major and
assignment)
Template is not used appropriately, or documentation format is
rarely followed correctly.
Appropriate template is used, but some elements are missing or
mistaken. A lack of control with formatting is apparent.
Appropriate template is used. Formatting is correct, although
some minor errors may be present.
Appropriate template is fully used. There are virtually no errors
in formatting style.
All format elements are correct.
5.0 %Research Citations (In-text citations for paraphrasing and
direct quotes, and reference page listing and formatting, as
appropriate to assignment and style)
No reference page is included. No citations are used.
Reference page is present. Citations are inconsistently used.
Reference page is included and lists sources used in the paper.
Sources are appropriately documented, although some errors
may be present
Reference page is present and fully inclusive of all cited
sources. Documentation is appropriate and citation style is
usually correct.
In-text citations and a reference page are complete and correct.
The documentation of cited sources is free of error.
100 %Total Weightage
Legal :
1-Does it have any compounds that are illegal?

5. 2-Does the owner have the right to open the factory?
3- Is the product approved by the government?
4- How are we going to face the law suits against the factory?
5- How can we save our product from being copied or stolen?
economic :
1-Is the production profitable?
2-What are the expenses of the project?
3-What is the budget for the advertising purposes?
Safety :
1-Is there any risk of toxic leaks?
2-Is there any risk of explosion?
3- What kind of insolation will be used?
4- What will the workers be wearing while working at the
factory?
Health :
1-Will the procedures of making this product have side effects
in the workers?
2- willthe product cause any diseases or infections for the
users?
Social impact :
1-Would people agree to open a factory in their back yard?
2-How are we going to advertise this product to the people?
3-Will the factory solve the jobsproblems ?
Technical/Engineering :

6. 1-What are the equipment that going to be used in the factory?
2-How often will the machines need maintenance?
3-How many engineers the factory will need ?
Quality :
1-How efficient will the product be?
2- What is the needed amount of contaminants allowed to make
CPVC?
Governmental/Regularity :
1-To which type of people I’m going to sell the product?
2-What is the maximum amount of producing the CPVC that is
allowed by the government?
Environmental :
1-Will the product cause Pollution?
2-How can we decrease the bad affection of the product to the
environment?
3- How can we make the product friendly to the environment?
X = Xylene
T = Toluene
B = Benzene

7. Distillation
Column
1
Distillation
Column
1
1
F1 = ?
F2 = ?
F4 = ?
F5 = ?
Yx3 =
YT3 =
YB3 =
Yx2 = ? YT2 = ?
YB2 = ?
YXi = .45
YTi = .25
YB1= .30
Yx5 = ? YT5 = ?
YB5 = ?
97% of B in F2

8. Yx4 = 0
YT4 = .06
YB4 = .94
96% of X in F1
2
3
4
5
CHE 1101 Fall 2014 Name
_______________________________
I have neither given nor received help on this exam from anyone
except Dr. Brenner.
Merck’s Vioxx is a COX-2 type inhibitor that has proven to be
highly effective as a nonsteroidal anti-inflammatory painkiller.
In fact, it was the only medication that was effective for my
father’s headaches before it was discontinued because the
lawyers for several patients’ families alleged that Vioxx caused
their clients’ loved ones to have heart attacks or strokes and, in
some cases, die. There is some justification for this allegation,
as Vioxx does cause blood platelets to stick together. The
synthesis of Vioxx is as follows:
Step 1: Aluminum chloride catalyst is completely dissolved in
an excess of benzene, which reacts via Friedel-Crafts alkylation

9. -butyrolactone (also called 2-oxacyclopentanone) as
shown below.
Step 2: After recovering and recycling all excess catalyst and
reactants from step 1, the product from step 1 undergoes a
dehydrogenation/lactonization (ring closing) reaction in a fixed
bed reactor at 600oC over a Cr2O3 catalyst. Note that because
the reaction is in a fixed bed reactor, the Cr2O3 is not contained
in the product stream from step 2. The main product is purified,
and the reactant is recycled to the beginning of step 2. The
leftover hydrogen, after separation from the main product and
the reactant, is sold as a secondary product. Assume that the
main product and the reactant in Step 2 have no measurable
vapor pressure, so that the separation of the hydrogen from
them is straightforward.
+ H2
Step 3: The main product from step 2 is once again exposed to
aluminum chloride catalyst dissolved in an excess of benzene.
This mixture reacts via Friedel-Crafts alkylation again to yield
the three-ring compound below. Excess benzene, aluminum
chloride, and reactant are recycled to the beginning of step 3,
after separation from the three-ring product from step 3.
Step 4: The three-ring product from step 3 is then reacted via
Friedel-Crafts acylation (not alkylation) with a mixture of yet

10. more aluminum chloride catalyst dissolved in chloroform
(CHCl3), and methylsulfonyl chloride. The Vioxx product is
finally purified from the reactants, solvent, and catalyst, all of
which are recycled to the start of Step 4.
1) (25 pts.) Create a Microsoft Word file named
yourlastnameexam1no1.doc (e.g. brennerexam1no1.doc) that
contains a questions & issues sheet for the synthesis of Vioxx.
Credit will be assigned for specificity, depth of insight, and
creativity of the questions asked, thoroughness of category
coverage, identification of the most important issues, and the
number of questions asked.
2) (55 pts.) Based on your questions & issues sheet, develop
a thoroughly process flowsheet for the synthesis of Vioxx in
Microsoft PowerPoint, and save the file as
yourlastnameexam1no2.ppt. Label as thoroughly as possible.
Purge feeds as necessary. If there are any waste products,
recycle them, incinerate them, or explain why they are not
hazardous. Recycle wherever possible. Separations are not
specified, but are necessary. During your first attempt at this
problem, I highly recommend just putting in generic separations
units, and then before turning in your first draft, describing the
potential separations options. Students can ask for any number
of clarifications. Please allow 24 hours for feedback.
BONUS (2 pts.) Use Isis/Draw to draw Vioxx. Right click on
Draw23.exe to save it after going to
http://my.fit.edu/~jbrenner/che11012/Applications/
name = fltech password = brenner
3) (5 pts.) Go to an appropriate web site to find the MSDS for
benzene. What organs inside you, if any, are target organs, for

11. benzene? Save the MSDS information for benzene as a .pdf file.
Find the concentration of benzene in a well-ventilated room that
would be 20% of the lower explosive limit (LEL). Would it be
safe to breathe that high a concentration of benzene? Report
your results in yourlastnameMSDS.doc.
4) (5 pts.) Perform an advanced search using
http://www.bing.com on Vioxx AND COX-2 AND inhibitor
AND legal AND “heart attack”, and report the number of hits
(results) for such a search in a file you name
yourlastnamewebsearch.doc. Put the words “heart attack” in the
exact phrase dialog box when doing the search. Your answer
should be between 10,000 and 1,000,000 hits.
5) (5 pts.) Create a WinZip file named yourlastname.zip
containing all of your files.
6) (5 pts.) Send the WinZip file to [email protected] as an
e-mail attachment.
Page 2 of 2
O
O
(
C
H
2
)
3
C
O
2
H
(
C
H
2
)

12. 3
C
O
2
H
O
O
O
O
O
O
O
O
O
O
S
O
O
C
H
3
S
O
O
Cl
C
H
3
+
AlCl
3
Cr
2
O
3
600

13. o
C
+
AlCl
3
AlCl
3
CHCl
3
+