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Plegable : Biología Molecular - Medicina UPB
1. Flip of Mitotic Spindle Has Disastrous Consequences for Epithelial Cells
and
Sex Chromosome Shocker: The 'Female' X a Key Contributor to Sperm Production
Deisy Tatiana Sánchez Zapata
Medicine Estudent – Molecular Biology
UPB
4. INTRODUCTION
The cell cycle is the basis for the
reproduction of organisms
The cell cycle is the basis for the
reproduction of organisms
The X chromosome has a close
relationship with sperm cells
The X chromosome has a close
relationship with sperm cells
5. Flip of Mitotic Spindle Has
Disastrous Consequences for
Epithelial Cells
Science Daily
(July. 21, 2013)
6. Flip of Mitotic Spindle Has Disastrous Consequences for Epithelial Cells
•Human epithelial cells are anchored to the extracellular matrix
and other cells by specialized proteins and for this property has
a significant role in the maintenance of epithelial cell polarity,
however in metastatic cancer cells this property is absent
•Binding complexes are of great importance for maintaining
cellular integrity even in the event of cell division
7. Flip of Mitotic Spindle Has Disastrous Consequences for Epithelial Cells
Apoptosis is a fundamental process that is altered in malignant neoplastic processes
8. Flip of Mitotic Spindle Has Disastrous Consequences for Epithelial Cells
Current research shows that if you directly disrupts the
mitotic spindle, cells begin to detach from the epithelium,
it was concluded that when researchers used
fluorescence, this technique showed that the mitotic
spindle poles are very close molecular contact regions of a
cell with other cells.
10. Sex Chromosome Shocker: The 'Female' X a
Key Contributor to Sperm Production
Science Daily
(July. 21, 2013)
11. Sex Chromosome Shocker: The 'Female' X a Key Contributor to Sperm Production
• The X chromosome has a close relationship with male reproductive health.
• The Y chromosome has several regions of large palindromes while chromosome x
presents ampliconic regions and genes associated with sperm production.
12. The gene expression sequences ampliconic in
the X chromosome is largely restricted to the
testis. At present it is known at this time that
these genes are only expressed in
spermatogenic cells themselves.
Sex Chromosome Shocker: The 'Female' X a Key Contributor to Sperm Production
13. The content of X chromosome genes is conserved and shared among mammals.
Sex Chromosome Shocker: The 'Female' X a Key Contributor to Sperm Production
14. Human X chromosomes in relation to the
mouse X chromosomes have a ratio of 95% in
the studied was identified that there are 340
genes that are identical between the two
species
Sex Chromosome Shocker: The 'Female' X a Key Contributor to Sperm Production
17. MEDICAL UTILITY
Flip of Mitotic Spindle Has Disastrous Consequences for Epithelial Cells
The recent advances in the process of cell division, allow to identify and
understand in a better way the genesis of tumors, is why this type of research open
a great outlook for multifactorial process of cancer.
18. MEDICAL UTILITY
Sex Chromosome Shocker: The 'Female' X a Key Contributor to Sperm Production
This type of research have great contribution in reproduction and male infertility also
through several studies it was concluded that several genes present on the X
chromosome are linked to cancer of the testis, these recent developments are of
great utility to men's health
19. BIBLIOGRAPHY
• Gibson Matt. Flip of Mitotic Spindle Has Disastrous Consequences for Epithelial
Cells. Science Daily[Internet News]; 2013[July, 21]. Web Site:
http://www.sciencedaily.com/news/health_medicine/
• Hahn B-S, Labouesse M. Tissue integrity: Hemidesmosomes and resistance to
stress. Science Direct [October 2011], Edition (11); 2013[July, 26].Web Site:
http://www.sciencedirect.com/science/article/
• Fearer Matt. Sex Chromosome Shocker: The 'Female' X a Key Contributor to
Sperm Production. Bio- Medicine[Internet News]; 2013[July 21]. Web Site:
http://www.bio-medicine.org/biology-news-1/Sex-chromosome-shocker-3A-
The-female-X-a-key-contributor-to-sperm-production-31099-2/
