Researchers like Dr. David Greene R3 Stem Cell believe that performing stem cell transplants without the need for radiation or chemotherapy would be revolutionary. It might stop infections, problems with bleeding, organ damage, and dangerously low blood cell counts. Additionally, it has specific implications for using gene therapy or bone marrow transplants on patients with non-cancerous conditions, like sickle cell anemia, when it's imperative to avoid the toxicities of conditioning brought on by chemotherapy or radiation.

1. r3stemcell.com
Dr David Greene Arizona

2. STEM CELLS: A SAFER TRANSPLANT
METHOD
A cutting-edge technique called stem cell therapy can potentially treat
all types of debilitating diseases. These disorders are evolving as quickly
as technology. Most patients with these severe illnesses are not
newborns. They have lived on our planet since the very beginning of
human history. Before this, human technology failed to locate them.
Medical science today allows for treating many diseases that were long
believed to be fatal, including tuberculosis and smallpox.

3. WHAT DISEASES CAN BE CURED WITH
STEM CELLS?
This approach, developed by researchers like Dr. David Greene, could treat
almost all diseases previously thought to be incurable. It is quite normal for
everybody when the question evolves from people: What diseases can be
cured with stem cells? For example, let’s watch out for stem cell
transplantation is the most effective method of treating leukemias,
lymphomas, and other difficult-to-treat blood cancers. The therapy eliminates
many cancer cells from the blood, lymph nodes, and bone marrow by replacing
donor stem cells with the patient's blood-forming stem cells.

4. However, many patients with deadly blood cancers are too weak to undergo
stem cell transplantation. This is because a patient's stem cells must first be
destroyed by intensive chemotherapy and even total body radiation before
obtaining stem cells from a donor. This so-called conditioning regimen helps
the body get rid of cancer cells that are still there, makes way for incoming
donor stem cells, and weakens the patient's immune system so it can't defend
against the donor's stem cells. Unfortunately, patients are significantly more
likely to experience infections, organ damage, and other potentially fatal side
effects due to the toxicity and immune system suppression brought on by
conditioning regimens.

5. Radiation and chemotherapy-free stem cell transplantation are possible thanks
to research. Instead, an immunotherapeutic approach is used, which combines
drugs that prevent the immune system from rejecting newly donated stem cells
with the selective elimination of bone marrow's blood-forming stem cells. The
innovative approach prevented the dangerously low blood cell counts
characteristic of traditional therapy in mice who successfully got stem cell
transplants from mice models that were unrelated to them. According to the
information, leukemia might be successfully treated with stem cell transplants.

6. Researchers like Dr. David Greene R3 Stem Cell believe that performing stem
cell transplants without the need for radiation or chemotherapy would be
revolutionary. It might stop infections, problems with bleeding, organ damage,
and dangerously low blood cell counts. Additionally, it has specific implications
for using gene therapy or bone marrow transplants on patients with non-
cancerous conditions, like sickle cell anemia, when it's imperative to avoid the
toxicities of conditioning brought on by chemotherapy or radiation.

7. As an option to high-dose chemotherapy and whole-body radiation, scientists
have exposed cells to toxic medications and linked these chemicals to antibodies
targeting specific surface proteins expressed primarily on bone marrow stem
cells. Only when these antibody-drug conjugates (ADCs) bind to specific proteins
are stem cells able to ingest them. As a result, the drug dosage inside the cell is
released, which ultimately causes cell death. To specifically target two different
proteins on the surface of blood stem cells, the researchers created two different
ADCs. By utilizing the ricin derivative saporin as the therapeutic payload, the risk
that they could harm other cell types is reduced.

8. The Janus kinase (JAK) inhibitors were given to the mice by the researchers to
suppress their immune systems and prevent the recipient's immune system from
later rejecting the donor cells. Researchers like Dr. David Greene R3 Stem Cell
used the drug baricitinib, which is used to treat rheumatoid arthritis, as their
major treatment in this study. They discovered that baricitinib prevented immune
cells from attacking recipient stem cells from donors, such as T cells and natural
killer cells.

9. Using JAK inhibitors and antibody-drug conjugates, researchers were able to
accomplish a transplant between two very different breeds of mice. Additionally,
scientists found that the new method in a typical mouse leukemia model established a
balance between donor immune cells fighting leukemia cells and not attacking the
recipient's healthy tissues.
www.r3stemcell.com