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4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 2/15
CANNABINOID COVID TREATMENTS
bi id h i
 Article List (https://cannabis.net/mycannabis/c-blog)
4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 3/15
Cannabinoids vs COVID - The First
Cannabinoid-Based COVID-19 Treatment
Hits the Public Market
How well do cannabis cannabinoids help treat patients with COVID-19?
Posted by:

DanaSmith, today at 12:00am
It’s been three years since the pandemic struck, and while for many of us, it seems life has gone back to normal, there
are still thousands of people who have or are going to get COVID-19 (https://cannabis.net/blog/opinion/do-the-antiviral-
properties-of-cannabis-translate-to-the-coronavirus-covid19).
4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 4/15
But thanks to science, vaccines, (https://cannabis.net/blog/medical/how-cannabis-helps-with-vaccine-side-effects') and
medications, even more lives have been saved. However, that doesn’t mean the fight is over. The virus still very much
exists around us and that’s why we need more advanced treatments. Thankfully, researchers have found that cannabis,
hemp, and its therapeutic cannabinoids, has the potential to fight and treat COVID-19.
Now a company has developed the first product based on cannabinoid acids designed to prevent and treat COVID-19.
Van Breemen, which makes plant-based and wellness products, has created the hemp-based Original Wellness Formula,
a blend founded by researcher Dr. Richard van Breemen
(https://www.benzinga.com/markets/cannabis/22/03/26168684/researcher-who-discovered-cannabinoid-acids-may-
prevent-covid-19-infection-launches-his-own-comp) of the Oregon State’s Global Hemp Innovation Centre, College of
Pharmacy and Linus Pauling Institute, reports Benzinga
(https://www.benzinga.com/markets/cannabis/22/03/26351898/exclusive-first-product-based-on-research-that-
discovered-cannabinoid-acids-may-prevent-covid-19). Dr. van Breemen just launched his company as he has founded
his work based on research discovering that some cannabinoid acids within the hemp plant is beneficial for treating and
preventing coronavirus.
Last January, Dr. van Breemen’s research paper called “Cannabinoids Block Cellular Entry of SARS-CoV-2 and the
Emerging Variants” (https://pubmed.ncbi.nlm.nih.gov/35007072/) was published in the renowned medical journal,
Journal of Natural Products. It was a breakthrough for the industry and the world as a whole, as scientists were still
struggling to find means of preventing and treating this mysterious virus. They intend to submit the formula to the Food
and Drug Administration (FDA) soon for approval.
4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 5/15
“We believe in elevating the conversation by bringing doctors and scientists to the table and delivering a product we can
stand behind,” said company co-founder & CEO, Jacob Crabtree to Benzinga. “Van Breemen’s Wellness Formula is that
product,” he said.
“Our goal is to achieve optimal health with the use of plants and science, transforming the way we view complementary
medicine,” van Breemen said. “Cannabinoids such as CBGA and CBDA are not controlled substances like THC, the
psychoactive ingredient in marijuana. These cannabinoids are abundant in hemp and have a positive safety profile in
humans. We are extremely proud to offer our first such hemp-based product to consumers,” he said.
The Wellness Formula Product’s original flavor is pineapple, with more flavors to be developed soon. It’s designed to be
applied sublingually, and is a full-spectrum cannabis product with 124mg in each serving. The suggested retail price is
currently at $49.99.
4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 6/15
The Study
Dr. van Breemen led the study which found that CBDA and CBGA were the most promising cannabinoids for fighting the
SARS-CoV-2 spike glycoprotein. In the trials, they found that it was successful in blocking the human epithelial cell when
a pseudovirus expressed the spike glycoprotein.
It was also significant that both cannabinoids derived from hemp were successful stopping the infection
(https://cannabis.net/blog/videos/which-marijuana-strains-block-the-coronavirus-cellular-pathways-the-best-dr.-
kovalchuk-explains), as well as its variants including the beta and alpha strain. The study authors indicated that the
concentrations needed to stop the infections of 50% of the viruses was achievable clinically. Additionally, data on CBDA
bioavailability indicated that serum concentrations and micromolar plasma can be used for tolerability and efficacy.
“Because we believe that the primary binding site for CBGA is allosteric, there may even be reduced evolutionary
pressure for SARS-CoV-2 to mutate their binding sites compared to the orthosteric binding sites typically favored by
neutralizing antibodies,” said the authors.
“Clinical trials are absolutely necessary to prove that the mechanism of action that we’ve identified in small molecules
actually can prevent infection in humans, or shorten the course of our COVID infection in humans,” said Dr. van
Breemen to The Sun (https://www.thesun.co.uk/health/17411704/marijuana-gummies-pill-covid-treatment/).
Can Cannabis Really Treat COVID?
The use of cannabis for treating and preventing COVID-19 (https://cannabis.net/blog/opinion/tips-for-dealing-with-
coronavirus-anxiety-and-fear-cannabis-and-pranayama-breathing) is nothing short of controversial. It has garnered
strong media attention, but we think this is warranted. After all, cannabis is renowned for its numerous therapeutic and
anti-viral properties.
But we can’t deny what the science says.
4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 7/15
Another recent study (https://www.science.org/doi/10.1126/sciadv.abi6110) suggests that CBD may help prevent or
treat the dreaded virus. According to the University of Chicago’s Marsha Rosner, lead researcher of a team who
discovered that CBD helped to treat the virus in laboratory experiments, CBD does make a strong case without claiming
that it would work.
For their study, the researchers used small doses of purified CBD, similar to what patients with severe epilepsy would
medicate with. Rosner and her team discovered that instead of CBD preventing the virus from infecting cells, CBD acted
immediately once the virus entered the cells though it blocked it from replicating copies of itself through its effects on
interferon, an inflammatory protein.
Meanwhile, in 2020, another animal study (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480719/) discovered that
CBD could be effective in reducing the cytokines, which helped improve clinical symptoms in mice models that had
symptoms similar to COVID-19.
No Support From FDA
The FDA as well as the Federal Trade Commission (FTC) is warning consumers against using CBD for treating COVID-19.
They have issued 7 warning letters for hemp-CBD companies against claiming that their products can “mitigate, prevent,
treat, diagnose, or cure” a disease.
“The FDA has not approved or authorized any drug containing CBD for the treatment or prevention of COVID-19,” they
said.
“We request that you take immediate action to cease the sale of any unapproved and unauthorized products for the
mitigation, prevention, treatment, diagnosis, or cure of COVID-19,” writes the FDA.
For consumers, it’s best to consult with cannabis-knowledgeable doctors before self-medicating with cannabis for such
a life-threatening condition. However, we do hope that more research can be done to save more lives.
CANNABIS FOR COVID, WATCH THE INTERVIEW...
4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 8/15
(https://cannabis.net/blog/videos/which-marijuana-strains-block-the-
coronavirus-cellular-pathways-the-best-dr.-kovalchuk-explains)
HOW CANNABIS BLOCKS COVID PATHWAYS - DR. KOVALCHUK TALKS (https://cannabis.net/blog/videos/which-
marijuana-strains-block-the-coronavirus-cellular-pathways-the-best-dr.-kovalchuk-explains)!
What did you think?
  Keep reading... click here  
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4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
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(https://cannabis.net/blog/how-to/how-to-legally-get-weed-delivered-to-your-front-door)
HOW TO
How To Legally Get Weed Delivered To Your Front Door
This means that a patient doesn’t even have to go to a doctor’s office to get a cannabis recommendation. In some states you have the ability to have a video
conference with your physician to get your recommendation.
4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 12/15
NEWS
Moms are Using Cannabis More Than Ever During Pandemic Says Survey
4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market
https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 13/15
(https://cannabis.net/blog/news/moms-are-using-cannabis-more-than-ever-during-pandemic-says-survey)
A closer look into the statistics gives a clearer picture of which of the parents is more inclined to the purchase and use of cannabis during the pandemic. 16% of
moms, as opposed to 11% of dads, have relied on the use of cannabis during the period of the survey which corresponds with the period when the effects of the
coronavirus were starting to take a toll on the American public.
MEDICAL
CBD Blocks the Anxiety Caused by THC - How Exactly Does That Work?

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The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market.pdf

  • 1. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 2/15 CANNABINOID COVID TREATMENTS bi id h i  Article List (https://cannabis.net/mycannabis/c-blog)
  • 2. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 3/15 Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market How well do cannabis cannabinoids help treat patients with COVID-19? Posted by: DanaSmith, today at 12:00am It’s been three years since the pandemic struck, and while for many of us, it seems life has gone back to normal, there are still thousands of people who have or are going to get COVID-19 (https://cannabis.net/blog/opinion/do-the-antiviral- properties-of-cannabis-translate-to-the-coronavirus-covid19).
  • 3. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 4/15 But thanks to science, vaccines, (https://cannabis.net/blog/medical/how-cannabis-helps-with-vaccine-side-effects') and medications, even more lives have been saved. However, that doesn’t mean the fight is over. The virus still very much exists around us and that’s why we need more advanced treatments. Thankfully, researchers have found that cannabis, hemp, and its therapeutic cannabinoids, has the potential to fight and treat COVID-19. Now a company has developed the first product based on cannabinoid acids designed to prevent and treat COVID-19. Van Breemen, which makes plant-based and wellness products, has created the hemp-based Original Wellness Formula, a blend founded by researcher Dr. Richard van Breemen (https://www.benzinga.com/markets/cannabis/22/03/26168684/researcher-who-discovered-cannabinoid-acids-may- prevent-covid-19-infection-launches-his-own-comp) of the Oregon State’s Global Hemp Innovation Centre, College of Pharmacy and Linus Pauling Institute, reports Benzinga (https://www.benzinga.com/markets/cannabis/22/03/26351898/exclusive-first-product-based-on-research-that- discovered-cannabinoid-acids-may-prevent-covid-19). Dr. van Breemen just launched his company as he has founded his work based on research discovering that some cannabinoid acids within the hemp plant is beneficial for treating and preventing coronavirus. Last January, Dr. van Breemen’s research paper called “Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants” (https://pubmed.ncbi.nlm.nih.gov/35007072/) was published in the renowned medical journal, Journal of Natural Products. It was a breakthrough for the industry and the world as a whole, as scientists were still struggling to find means of preventing and treating this mysterious virus. They intend to submit the formula to the Food and Drug Administration (FDA) soon for approval.
  • 4. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 5/15 “We believe in elevating the conversation by bringing doctors and scientists to the table and delivering a product we can stand behind,” said company co-founder & CEO, Jacob Crabtree to Benzinga. “Van Breemen’s Wellness Formula is that product,” he said. “Our goal is to achieve optimal health with the use of plants and science, transforming the way we view complementary medicine,” van Breemen said. “Cannabinoids such as CBGA and CBDA are not controlled substances like THC, the psychoactive ingredient in marijuana. These cannabinoids are abundant in hemp and have a positive safety profile in humans. We are extremely proud to offer our first such hemp-based product to consumers,” he said. The Wellness Formula Product’s original flavor is pineapple, with more flavors to be developed soon. It’s designed to be applied sublingually, and is a full-spectrum cannabis product with 124mg in each serving. The suggested retail price is currently at $49.99.
  • 5. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 6/15 The Study Dr. van Breemen led the study which found that CBDA and CBGA were the most promising cannabinoids for fighting the SARS-CoV-2 spike glycoprotein. In the trials, they found that it was successful in blocking the human epithelial cell when a pseudovirus expressed the spike glycoprotein. It was also significant that both cannabinoids derived from hemp were successful stopping the infection (https://cannabis.net/blog/videos/which-marijuana-strains-block-the-coronavirus-cellular-pathways-the-best-dr.- kovalchuk-explains), as well as its variants including the beta and alpha strain. The study authors indicated that the concentrations needed to stop the infections of 50% of the viruses was achievable clinically. Additionally, data on CBDA bioavailability indicated that serum concentrations and micromolar plasma can be used for tolerability and efficacy. “Because we believe that the primary binding site for CBGA is allosteric, there may even be reduced evolutionary pressure for SARS-CoV-2 to mutate their binding sites compared to the orthosteric binding sites typically favored by neutralizing antibodies,” said the authors. “Clinical trials are absolutely necessary to prove that the mechanism of action that we’ve identified in small molecules actually can prevent infection in humans, or shorten the course of our COVID infection in humans,” said Dr. van Breemen to The Sun (https://www.thesun.co.uk/health/17411704/marijuana-gummies-pill-covid-treatment/). Can Cannabis Really Treat COVID? The use of cannabis for treating and preventing COVID-19 (https://cannabis.net/blog/opinion/tips-for-dealing-with- coronavirus-anxiety-and-fear-cannabis-and-pranayama-breathing) is nothing short of controversial. It has garnered strong media attention, but we think this is warranted. After all, cannabis is renowned for its numerous therapeutic and anti-viral properties. But we can’t deny what the science says.
  • 6. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 7/15 Another recent study (https://www.science.org/doi/10.1126/sciadv.abi6110) suggests that CBD may help prevent or treat the dreaded virus. According to the University of Chicago’s Marsha Rosner, lead researcher of a team who discovered that CBD helped to treat the virus in laboratory experiments, CBD does make a strong case without claiming that it would work. For their study, the researchers used small doses of purified CBD, similar to what patients with severe epilepsy would medicate with. Rosner and her team discovered that instead of CBD preventing the virus from infecting cells, CBD acted immediately once the virus entered the cells though it blocked it from replicating copies of itself through its effects on interferon, an inflammatory protein. Meanwhile, in 2020, another animal study (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480719/) discovered that CBD could be effective in reducing the cytokines, which helped improve clinical symptoms in mice models that had symptoms similar to COVID-19. No Support From FDA The FDA as well as the Federal Trade Commission (FTC) is warning consumers against using CBD for treating COVID-19. They have issued 7 warning letters for hemp-CBD companies against claiming that their products can “mitigate, prevent, treat, diagnose, or cure” a disease. “The FDA has not approved or authorized any drug containing CBD for the treatment or prevention of COVID-19,” they said. “We request that you take immediate action to cease the sale of any unapproved and unauthorized products for the mitigation, prevention, treatment, diagnosis, or cure of COVID-19,” writes the FDA. For consumers, it’s best to consult with cannabis-knowledgeable doctors before self-medicating with cannabis for such a life-threatening condition. However, we do hope that more research can be done to save more lives. CANNABIS FOR COVID, WATCH THE INTERVIEW...
  • 7. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 8/15 (https://cannabis.net/blog/videos/which-marijuana-strains-block-the- coronavirus-cellular-pathways-the-best-dr.-kovalchuk-explains) HOW CANNABIS BLOCKS COVID PATHWAYS - DR. KOVALCHUK TALKS (https://cannabis.net/blog/videos/which- marijuana-strains-block-the-coronavirus-cellular-pathways-the-best-dr.-kovalchuk-explains)! What did you think?   Keep reading... click here   (https://cannabis.net/blog) 0 0 0 0 0 0
  • 8. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 9/15 Leave a Comment: What are your thoughts? Submit EVENTS (HTTPS://CANNABIS.NET/BLOG/EVENTS) B2B (HTTPS://CANNABIS.NET/BLOG/B2B) VAPING (HTTPS://CANNABIS.NET/BLOG/VAPING) STRAINS (HTTPS://CANNABIS.NET/BLOG/STRAINS) RECIPES (HTTPS://CANNABIS.NET/BLOG/RECIPES) SMOKE (HTTPS://CANNABIS.NET/BLOG/SMOKE) CATEGORIES
  • 9. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 10/15 VOTE (HTTPS://CANNABIS.NET/BLOG/VOTE) FUNNY (HTTPS://CANNABIS.NET/BLOG/FUNNY) NEWS (HTTPS://CANNABIS.NET/BLOG/NEWS) PERSONAL STORY (HTTPS://CANNABIS.NET/BLOG/PERSONAL-STORY) OPINION (HTTPS://CANNABIS.NET/BLOG/OPINION) HISTORY (HTTPS://CANNABIS.NET/BLOG/HISTORY) TECHNOLOGY (HTTPS://CANNABIS.NET/BLOG/TECHNOLOGY) DABS (HTTPS://CANNABIS.NET/BLOG/DABS) SPORTS (HTTPS://CANNABIS.NET/BLOG/SPORTS) HOW TO (HTTPS://CANNABIS.NET/BLOG/HOW-TO) SEXY (HTTPS://CANNABIS.NET/BLOG/SEXY) LOCATIONS (HTTPS://CANNABIS.NET/BLOG/LOCATIONS) VIDEOS (HTTPS://CANNABIS.NET/BLOG/VIDEOS) INTERVIEW (HTTPS://CANNABIS.NET/BLOG/INTERVIEW) MEDICAL (HTTPS://CANNABIS.NET/BLOG/MEDICAL) FEATURED
  • 10. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 11/15 (https://cannabis.net/blog/how-to/how-to-legally-get-weed-delivered-to-your-front-door) HOW TO How To Legally Get Weed Delivered To Your Front Door This means that a patient doesn’t even have to go to a doctor’s office to get a cannabis recommendation. In some states you have the ability to have a video conference with your physician to get your recommendation.
  • 11. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 12/15 NEWS Moms are Using Cannabis More Than Ever During Pandemic Says Survey
  • 12. 4/7/22, 7:23 AM Cannabinoids vs COVID - The First Cannabinoid-Based COVID-19 Treatment Hits the Public Market https://cannabis.net/blog/medical/cannabinoids-vs-covid-the-first-cannabinoidbased-covid19-treatment-hits-the-public-market 13/15 (https://cannabis.net/blog/news/moms-are-using-cannabis-more-than-ever-during-pandemic-says-survey) A closer look into the statistics gives a clearer picture of which of the parents is more inclined to the purchase and use of cannabis during the pandemic. 16% of moms, as opposed to 11% of dads, have relied on the use of cannabis during the period of the survey which corresponds with the period when the effects of the coronavirus were starting to take a toll on the American public. MEDICAL CBD Blocks the Anxiety Caused by THC - How Exactly Does That Work?