The FDA approves a CBD for opioid addiction study, read this https://cannabis.net/blog/medical/can-cbd-help-get-people-off-opioids-biotech-firms-gets-fda-approval-to-study-cbdbased-drug-for

1. 1/27/22, 4:40 PM Can CBD Help Get People Off Opioids? - Biotech Firms Gets FDA Approval to Study CBD-Based Drug for Opioid Addiction
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2. 1/27/22, 4:40 PM Can CBD Help Get People Off Opioids? - Biotech Firms Gets FDA Approval to Study CBD-Based Drug for Opioid Addiction
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CBD FOR OPIOIDS
Can CBD Help Get People Off Opioids? -
Biotech Firms Gets FDA Approval to Study
CBD-Based Drug for Opioid Addiction
The FDA is looking into how CBD can help people get off opioids
Posted by:
Joseph Billions , today at 12:00am
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3. 1/27/22, 4:40 PM Can CBD Help Get People Off Opioids? - Biotech Firms Gets FDA Approval to Study CBD-Based Drug for Opioid Addiction
https://cannabis.net/blog/medical/can-cbd-help-get-people-off-opioids-biotech-firms-gets-fda-approval-to-study-cbdbased-drug-for 4/15
Ananda Scientific Inc., a biotech pharma firm in the U.S, recently announced that it would soon commence a study on
the application of CBD-derived drugs as a medicinal alternative for opioid-use disorder. This announcement came a few
days after the company's proposal was approved by the Food and Drug Administration (FDA).
The FDA approved the pharma's CBD-based Nantheia ATL5, an Investigational New Drug (IND), to be used as a potential
treatment to cure or manage opioid use disorder.
The Epidemic of Opioid Use Disorder
Both Canada and the United States are facing a massive opioid epidemic. Both governments have also approved dozens
of research projects to look into potential treatment options for managing opioid use disorder.
In the past two decades, at least 800,000 Americans have died from drug overdoses, many of which can be traced to
opioids. From 2019 to this day, about 65% of fatal drug ODs were due to opioids like heroin, synthetic opioids, and
prescription opioids. The figure is still rising gradually.
Through decades of research, scientists have developed various treatment options, none of which seems to have a
long-lasting effect, as relapse still remains as pervasive as ever. A few of the FDA-approved opioid treatment
medications have efficiently eased the grimness of withdrawal symptoms. They have also helped in preventing relapses.
The downside is that some of these medications come with their own risks, and they do not have the same impact on all
patients. Some of these traditional opiate replacement therapies like methadone and buprenorphine are primarily
inaccessible due to legal and logistical constraints.
Cannabis-based medical treatments are one of the novel alternatives being looked into for opiate use disorder
therapies. Ananda Scientific Inc. has been able to establish that CBD could help in lessening the severity of opiate use
disorder.

4. 1/27/22, 4:40 PM Can CBD Help Get People Off Opioids? - Biotech Firms Gets FDA Approval to Study CBD-Based Drug for Opioid Addiction
https://cannabis.net/blog/medical/can-cbd-help-get-people-off-opioids-biotech-firms-gets-fda-approval-to-study-cbdbased-drug-for 5/15
Details about Ananda's Study
The new clinical trial will take place at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at the
University of California, Los Angeles. According to the press release, the National Institute on Drug Abuse is funding the
program, which has been slated to run for nine weeks.
Sohail R. Zaidi wrote that the new study would go a long way toward boosting the clinical development efforts targeted
at opioid addiction. Non-addictive therapy is the best option for patients suffering from opioid use disorder, and this
new drug, Nantheia, could be it. The objective of the research is to determine the potential safety and impact of CBD as
an alternative therapy for patients with opioid use disorders. It would replace existing treatments like buprenorphine
and naloxone.

5. 1/27/22, 4:40 PM Can CBD Help Get People Off Opioids? - Biotech Firms Gets FDA Approval to Study CBD-Based Drug for Opioid Addiction
https://cannabis.net/blog/medical/can-cbd-help-get-people-off-opioids-biotech-firms-gets-fda-approval-to-study-cbdbased-drug-for 6/15
The summary of the proposal indicated that 60 volunteers would be recruited from Los Angeles' Tarzana Treatment
Center. The Center manages its patients with buprenorphine and naloxone therapy.
The trial's lead investigators are Richard De La Garza, Ph.D., Professor of Psychiatry and Biobehavioral Science and
Molecular and Medical Pharmacology at the same Institute, Edythe London.
About Nantheia, ATL 5.
Nantheia is a soft-gel capsule that is ingested orally. Each pill contains 100 mg of CBD. Ananda's Liquid Structure
technology, licensed by Lyotropic Delivery Systems, has contributed immensely to the production of the drug. The
delivery system ensures that the CBD effects are enhanced and stabilized when ingested. It has also helped in creating a
mechanism to facilitate voluntary opioid sparing through cannabidiol therapeutics.
The recent approval by the FDA is the fourth IND approval for the Nantheir product line. Zaidi says that these approvals
are in line with the company's vision of making CBD one of the critical treatments for opioid use disorder. The drug
opens up a new possibility for CBD therapeutics to be used to ameliorate opioid intake in patients who are battling
opioid addictions.
The development of this crucial and promising therapeutic alternative will positively affect the lives of millions of people
in North America suffering from opiate use disorder. Zaidi added that the welfare of these people would be improved
by advancing the applications for the Nantheia medication line.
In a press release, Dr. London said that she was optimistic about the collaboration with Ananda. She added that this
clinical trial is a start in resolving the opiate epidemic ravaging North America. The trial would begin as soon as the
volunteers are recruited. Now that the IND has been approved, there is very little reason to stall the advancement of
this trial.
Analgesics with CBD-Derived Medications

6. 1/27/22, 4:40 PM Can CBD Help Get People Off Opioids? - Biotech Firms Gets FDA Approval to Study CBD-Based Drug for Opioid Addiction
https://cannabis.net/blog/medical/can-cbd-help-get-people-off-opioids-biotech-firms-gets-fda-approval-to-study-cbdbased-drug-for 7/15
Opioids and cannabis are primarily used as analgesics. Both function remarkably well for relieving chronic pain. Since
the start of medical cannabis programs in states across the U.S. and Canada, statistics show that patients prefer the use
of cannabis to opioids. This caused a 40% reduction in the use of opioids. Fewer patients report side effects after using
cannabis medications than their opioid counterparts. Little research has produced reliable literature to show why
cannabis consistently shows better pain relief than opioid doses. Fewer has also established why cannabis could be a
potential treatment for managing opioid addictions.
Ananda Scientific Inc. is one of the few companies linking with research institutes to evaluate the medical benefits of
cannabinoids. The company is one of the pioneers of high-profile clinical studies using impressive delivery technologies
to make cannabis compounds more bioavailable. Many of the company's nutraceuticals are available in the US, UK, and
Canada. There are expansion plans in the works to introduce Africa, Australia, Europe, and China to the wonders of
cannabis-derived medications.
Bottom Line
Ananda and UCLA are working on a drug that could significantly lower the number of opioid-related deaths in the
United States, Canada, and the rest of the world. While primary care clinicians work each day tirelessly to identify and
treat people with opioid use disorder, it is commendable that a clinical trial is being conducted to profer more efficient,
long-lasting treatment options to resolve opioid addiction cases. The FDA should also try to approve other clinical trials
exploring the use of cannabis as an alternative or adjunct treatment for opioid use disorder. This is better than waiting
for the Ananda team to provide solutions.
MORE ON CBD FOR OPIOIDS, READ THIS...

7. 1/27/22, 4:40 PM Can CBD Help Get People Off Opioids? - Biotech Firms Gets FDA Approval to Study CBD-Based Drug for Opioid Addiction
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Inflammation is the root cause of dozens of chronic illnesses that plague us today. Inflammation occurs when the immune system is compromised, and leads to
organ, joint, and tissue damage in many parts of the body.

11. 1/27/22, 4:40 PM Can CBD Help Get People Off Opioids? - Biotech Firms Gets FDA Approval to Study CBD-Based Drug for Opioid Addiction
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Mexico’s Cannabis Legalization D-Day is Quickly Approaching (What Does it Mean for Global Markets?)
Mexico has the ability to become a world producer of cannabis if they can get the infrastructure right. It is believed that Mexico will follow a hybrid Colorado-
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market situation where one of the primary motivations will be export.

13. 1/27/22, 4:40 PM Can CBD Help Get People Off Opioids? - Biotech Firms Gets FDA Approval to Study CBD-Based Drug for Opioid Addiction
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MEDICAL
CBD Blocks the Anxiety Caused by THC - How Exactly Does That Work?
Once that molecule has been triggered, this results in anxiety as well as other negative effects including addiction and depression. For the study, the researchers
analyzed rats who were given THC and CBD at the same time. They found that these rates demonstrated reduced levels of paranoia and anxiety. Meanwhile, the
molecule known as ERK in the hippocampus, was shown to be normal. In other words, CBD effectively blocked the negative effects of THC in the brain.