The document describes a Russian medical apparatus called "Nadezhda" that uses low-level electromagnetic radiation to treat cancer patients. It has 9 generators that produce frequencies from 100-1300 MHz to selectively target cancer cells. Clinical trials from 1996-2001 showed it slowed tumor growth in mice by 20-25% and in humans, 27.4% of patients saw full regression and 37.5% saw partial regression of their cancer after treatment. The apparatus was recommended for medical use in Russia based on its clinical effectiveness against cancer.

1. NEW MEDICAL TECHNOLOGIES
OF RUSSIAN FEDERATION
MEDICAL APPARATUS
"NADEZHDA"
"KNOW - HOW " PRODUCT
Moscow, 2014

3. Apparatus of the remote electromagnetic high
freguency radiation of low level with
NAME:
automatic control system
for the use complex cancer patients care
“Nadezhda”

4. General view of the medical apparatus “Nadezhda”
Pic.1
General view of the closed
apparatus
Pic.3
General view of the
open apparatus
Pic.3
General view of the upper
surface of the apparatus

5. Specifications:
Generators – 9 pieces;
Bandwidth from 100 to 1300 MHz, second and third harmonics of basic nine frequencies;
Modulation mode – frequency, modulation from 0 up to 200 MHz;
Power of each generator at a load of 50 ohm at fundamental harmonic – 10 ± 5 mW;
Total energy-flux rate – 4 : 6 mkW/sm²;
Power and frequency of power supply – 220V, 50Hz;
Power intake not more than 30 VA;
Protection class against electric-shock hazard – II type B;
Time between failure not less than - 1500 hours;
Time of the continuous working not less than - 8 hours;
Service life not less than - 10 years;
Overall dimensions not more than - 460x410x120 mm;
Weight not more than - 8 kg.

6. Application of the apparatus
Medical apparatus “Nadezhda” is dedicated for complex cancer diseases care.
Principle of therapeutic modality
The curative effect is achieved by the biomolecular differential absorption of high
frequency electromagnetic radiation, that leads to the change of its energetic state and
in the following doesn’t permit these molecules to take a full part in the process of
proliferation of cells
Method of achievement of curative effect
The patient is effected by the spectrum of high frequency electromagnetic radiation of low level,
formed by nine discretely elected in predetermined combinations frequencies of radio range
(100-1300 MHz), with the use of second and third harmonics of basic frequencies, with the
energy flux-rate of less than 10 mkW/sm² and directive changing frequency modulation in the
range of 0-200 Hz.
Development prospects
Prognosis for the perspective are based on the unique theory, created by Fund “Nadezhda”,
which is found to the creation of medical apparatus “Nadezhda”. The apparatus is perspective
with regard to the extension of the possibilities of its use for the cure of other types of diseases,
as AIDS and tuberculosis, after the realization of additional clinical trials and the modification of
cure technique.

7. Application conditions
The cover of the apparatus – the unique aerial-radiator
Before starting the cure it’s necessary to defuse the static tension
from the patient.
The patient should be wearing the cotton clothes.
The patient should be in a handling radius of the apparatus in a
distance of not less than 1m and not more than 5m from the
apparatus. The distance of the patient from the apparatus depends
on the power of radiation of the apparatus and the tumor’s
occurrence depth.
0,5 м
In case of a group therapy the conditions of the patients’
positioning should answer the principle of the most power
absorption of each patient. For that the patients should be in a
0,5 м
distance of 0,5m from each other.
The significant factor of the patients’ positioning is the absence of
other objects or patients on the way of the signal from the apparatus
to the patient.
The duration of the radiation effect depends on the general
condition of the patient, disease pattern, readings for the use of the
apparatus and is 50-180 minutes in a session. Sessions should
follow each other every 24 hours or in 24 hours.
Average total time of effect for a course of treatment: 12-24 hours.
Average total time for the whole course shouldn’t exceed 40
0,5 м
hours.
Note:
Medical apparatus “Nadezhda” can be applied autonomously or
together with the existing traditional cure methods.
Counter-indications:
Counter-indications for the cure process for the patient can be
pregnancy, thrombembolia, presence of implanted stimulators.

8. The use of the unique technique and apparatus
in curing cancer diseases guarantees:
tumor growth retardation;
localization of generalized processes;
reduction of pain syndrome
1-2 stages;
improvement of immunological status;
reduction of inflammatory processes and
forming of the favorable situation for the
acceleration of the process of angenesis;
forming of the sedation;
=
Radiation at the
frequencies of radio
range with the power flux
density of not less than
10 mkW/sm².
Besides, in case of the combined cure method the application of the apparatus ensures the abovementioned results,
and also to reduce the applied dose of the radiation therapy, to reduce negative effects of radial and chemotherapy
and to get the radiomodifying effect in case of radial therapy.

9. Principal pluses of the apparatus
the cure is realized in a noncontact and noninvasive way;
provides the cure for a group of patients;
selectively effects only cancer cells of the tumor and focuses of metastasis regardless of its location
and is secure for the normal cells of the organism;
doesn’t have side negative influence on the patient and operational staff, that is in the zone of
action of the apparatus;
doesn’t have home and foreign analogues;
is competitive and economical, low costs;
minor expenses for cure;
performed in the movable variant, compactness and convenience permit to use it at any moment, at
any place, without special equipped placing;
is perspective in the expansion of the possibilities of its use (cure).

10. The medical apparatus “Nadezhda” passed the following clinical trials:
1996-1998: Clinical trials of the breadboards of the apparatus on mice with transplanted tumor.
Ground: - extract from the protocol № 2 of 03.10.1996 of the Committee on new techniques of the Ministry of
Health of Russian Federation.
Place of realization:
Medical Radiological Research Centre Russian Academy of Medical Sciences, city of Obninsk;
1998-1999: Clinical trials of the breadboards of the apparatus on patients with cancer diseases.
Ground: - extract from the protocol №3 of 04.07.1998 of the Committee on new techniques of the Ministry of
Health of Russian Federation.
Place of realization:
Medical Radiological Research Centre Russian Academy of Medical Sciences, city of Obninsk;
Municipal Clinical Hospital of the city of Mytishy, Moscow Region;
Moscow Research Cancer Institution in the name of P.A. Gertsen and 11th Municipal Hospital (MNIOI) in
the name of P.A. Gertsen.
1999-2001: Clinical trials of the development types of the apparatus on patients with cancer diseases.
Ground: - extract from the protocol №3 of 04.07.1998 of the Committee on new techniques of the Ministry of
Health of Russian Federation.
Place of realization:
Medical Radiological Research Centre Russian Academy of Medical Sciences, city of Obninsk;
Russian Scientific Centre of Radiology and Nuclear Medicine of the Ministry of Health of Russian Federation;
Moscow Research Cancer Institution in the name of P.A. Gertsen.

11. The medical apparatus “Nadezhda” after successful realized clinical trials is
recommended by Ministry of Health of Russian Federation to the use in
medicine practices and in series production.
Grounds for the use – availability of the full package of permissive
documents:
extract from the protocol №3 of 05.07.2001 of the Committee on new techniques of the Ministry of
Health of Russian Federation on the use of the apparatus in the medical practices;
Registration Certificate FSR 2012/13159 of 14.03.2012;
Certificate of Conformity 6563062 №ROSS RU.IMO2.B12699 of 15.04.2005;
Sanitation-and-epidemiological conclusion № 77.99.28.944.D.003230.06.05 of 10.06.2005;
Certificate for a trademark № 282671 of 22.04.2005;
Permit of State Committee on Radiofrequencies “On frequencies allocation” № 04-03-05-024 of
06.12.2004.

12. Patent status of the device
Russia
Patent received for the device for № 2155084 of 27.08.2000
Patent received for the device for № 2209642 of 10.08.2003
Ukraine
Patent received for the device for № 7491of 15.12.2005
Israel
Patent received for the device for № 141105 of 11.07.2006
Germany
Patent received for the device for № 202 21 025.1 of 27.10.2004

13. From the materials of realized clinical trials
Estimate of efficiency of the influence of the apparatus
Experimental section
For the purpose of the efficiency of the apparatus of the apparatus for the cure of newgrowths
took place trials on male-mice of the line C57B1/6 in the age of 3,5 months with the intorted tumor of lungs
Lewis (strain LLC). The results were treated by the methods of variation statistics and are shown in the table:
Control
Volume of the
tumor at the 21st
Mass of the
tumor at the 21st
Number of
metastases in
day, sm³
Group
Volume of the
tumor at the 12th
day, sm³
day, sm³
lungs, M - m
0,7 ÷ 0,2
5,7 ÷ 0,4
5,5 ÷ 0,4
22,7 ÷ 2,2
0,8 ÷ 0,2
4,3 ÷ 0,2
4,2 ÷ 0,3
17,7 ÷ 1,9
Influence of the
apparatus
Conclusion: the influence of the apparatus retards the growth of the tumor and its metastasis
approximately to 20-25%.

14. From the materials of realized clinical trials
Estimate of efficiency of the influence of the apparatus
№
Neoplasm form
Including
Number of
patients
Mail
Female
Age interval
1
Carcinoma of uterus
14
-
14
65-73
2
Large intestine cancer
9
4
5
65-66
3
Carcinoma of uterine cervix
10
-
10
42-62
4
Carcinoma of uterine tube
4
-
4
48-58
5
Ovarian carcinoma
12
-
12
38-59
6
Vulva carcinoma
5
-
5
31-75
7
Breast cancer
45
-
45
32-54
8
Thyroid gland cancer
10
-
10
38-57
9
Chronic lymphatic leukemia
3
-
3
58-65
10
Chronic myeloleukemia
3
3
-
65-72
11
lymphosarcoma
8
8
-
37-63
12
Lymphogranulematosis
6
4
2
22-46
13
Rectal cancer
13
11
2
43-67
14
Carcinoma of nasopharynx
1
1
-
44
15
Esophadus cancer
22
20
2
44-72
16
Carcinoma of liver
5
4
1
69-71
18
Сarcinoma of lung
25
17
8
40-69
19
Сarcinoma of stomach
15
5
10
41-68
20
Carcinoma of oral cavity
2
2
-
49-54

15. From the materials of realized clinical trials
Estimate of efficiency of the influence of the apparatus
№
Neoplasm form
Including
Number of
patients
Mail
Female
Age interval
21
Carcinoma of pancreas
3
2
1
66-73
22
Carcinoma of larynx
5
4
1
55-79
23
Carcinoma of blind gut
2
-
2
51-63
24
Carcinoma of sigmoid gut
2
-
2
44-51
25
Carcinoma of prostate gland
27
27
-
32-89
26
Gallbladder carcinoma
1
-
1
64
27
Melanoma
4
1
3
45-58
28
Chondrosarcoma
1
1
-
42
29
Esophadus cancer
4
1
3
54-64
30
Carcinoma of jaw
5
1
4
41-75
31
Kidney cancer
5
2
3
42-73
32
Soft tissues sarcoma
1
1
-
36
33
Carcinoma of piriform sinus
2
2
-
41-42
34
Spinal column affection wothout primary lesion
2
-
2
65-75
35
Carcinoma of tongue
4
3
1
41-57
36
Carcinoma of urinary bladder
3
2
1
54-64
37
Swelling of a brain
1
-
1
39
38
Glioblastoma
2
2
39
Neuroblastoma
1
1
-
45
290
127
163
22-89
Total :
52-76

16. From the materials of realized clinical trials
Estimate of efficiency of the influence of the apparatus
For the purpose of the efficiency of the apparatus of the apparatus for the cure of the
patients with cancer diseases the two groups were formed in random order. One of them, Group
(I), incurred the real influence of the apparatus, and for the other, Group (II), the placebo effect.
The trials were carried out by the double randomized method. All the patients had the
expressed, characterized by the disease development: chronic pain syndrome, reduction of the
degree of freedom in case of physical activity, reduced performances of hemotogenic
activity, etc. The character of the disease is that it is impossible to recommend surgical
methods, and the cure by conservative methods (radial and chemotherapy) resulted to be
ineffective, or the efficiency was less than 20%.
The patients with clinical symptoms were estimated by antitumoral, wound
healing, anesthetic and immunomodulatory effects, forming of the sedation, localization of
generalized processes.

17. From the materials of realized clinical trials
Estimate of efficiency of the influence of the apparatus
The estimate of the efficiency of the therapeutical influence of the apparatus was held on the
objective and subjective characteristics.
The laboratory-instrumental research on the dynamics of the objective condition of the patient
was realized by: ultrasonic investigation, X-ray diagram, tomographic image, general blood
test, the analysis of biochemical and electrolytic composition of blood before the start of the
cure, at the 14th and 28th days at the moment of the beginning of the cure.
The dynamics of the performances of the immunological blood test of the patients with
radiation complications was examined.
The estimate of pains of the patients with pain syndromes was realized, by the approved
methods of World Health Organization (visual-analog scale and scale of verbal estimates in
grades).
All the patients were estimated on physical activity on the common scale of the estimate of
the general condition Karnovsky and the scale of physical scale, approved by World Health
Organization.

18. From the materials of realized clinical trials
Estimate of efficiency of the influence of the apparatus
Total info on the patients with cancer diseases, which took part in
clinical trials of the apparatus “Nadezhda”.
Number of
patients
Male
Female
Age interval
Medical Radiological Research Centre
Russian Academy of Medical Sciences,
city of Obninsk.
89
28
61
22-78 years
2.
Moscow Research Cancer Institution in
the name of P.A. Gertsen
50
32
18
31-77 years
3.
Russian Scientific Centre of Radiology
and Nuclear Medicine
58
30
28
28-89 years
4.
Municipal Clinical Hospital of the city of
Mytishy, Moscow Region
40
17
23
22-79 years
5.
11th Municipal Hospital (MNIOI) in the
name of P.A. Gertsen.
53
20
33
36-76 years
In total:
290
127
163
22-89 years
№
1.
Name of the institution

19. From the materials of realized clinical trials
Total clinical estimate of efficiency of the influence of the apparatus
In the clinical trials took part 290 patients.
The balance of frequencies of objective and subjective effects in the basic group (I) placebo group (II) is shown in the
tables:
Objective effect after the therapeutic influence of the apparatus
Effect
Without
Full
regression
Partial
regression
(100%CR)
(>50%PR)
I (197)
1.1% (2)
27.4% (54)
37.5% (74)
0
34.0% (67)
II (93)
0
0
0
58,0% (54)
42.0% (39)
Group
Group
Process
stabilization
effect
Progressing
Subjective effect after the therapeutic influence of the apparatus
Effect
Without
To reduce of
Improvement of
Improvement
Progressing
effect
the pain
immunological of
of gualite of
syndrome
paramoters
life
I (197)
58.7% (115)
67,9% (134)
55,4% (109)
0
34.0% (67)
II (93)
0
0
0
58,0% (54)
42.0% (39)

20. Efficiency of the influence of the apparatus
Along with the previously agreed in course of the cure by the therapeutic effects we
succeeded in:
o
to increase the immunologic status and antitumoral organism resistance;
o
to reduce the tolerance of the new growths to the influence of the radiation cure methods;
o
to reduce the risk of the complications development in case of chemotherapy;
o
to localize the generalized forms of the complications development;
o
to improve the life quality of the patients with the inveterate forms of cancer diseases of different
localization and anatomic forms, that is:



to reduce the intensity of the pain syndrome;
to improve the physical activity;
to improve the quality and to increase the duration of nocturnal sleep.

21. For notes
Moscow, 2014

22. For notes
Moscow, 2014

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