Neuroprotection

Magnesium Sulfate Neuroprotection GUIDELINES FOR REDUCTION OF Cerebral Palsy NOVEMBER 2010 CP results in Motor & Postural Dysfunction Commonly associated with Mental disability, and Abnormalities of Vision , Hearing , and Speech

ACOG COMMITTEE OPINION 455 MARCH 2010 ,[object Object],[object Object]

Riverside Neuroprotection MODIFIED BEAM TRIAL PROTCOL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Riverside Neuroprotection Modification of the BEAM trial ,[object Object],[object Object],[object Object],[object Object],[object Object]

Biologic Plausibility MgSO4 Neuroprotection ,[object Object],[object Object],[object Object]

Referenced by ACOG opinion 455 3 Largest RCT n = 4,184 ,[object Object],[object Object],[object Object],[object Object],[object Object],ACOG COMMITTEE OPINION 455 MARCH 2010

Meta Analysis Conclusions ,[object Object],[object Object],[object Object],[object Object]

NNT Prevention Ratios ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Prematurity results in CP ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Chorioamnionitis SYNERGISTICALLY Increases the risk of CP with Prematurity ,[object Object],[object Object],[object Object],Obstet Gynecol 2010;116:387–92 Clin Obstet Gynecol 1998 Dec;41(4):827-31 . Paediatr Perinat Epidemiol 1998 Jan;12(1):72-83

PVL ,[object Object],[object Object],[object Object]

< 5 % of CP results from Intrapartum Hypoxia Obstet Gynecol. 2006 Jun;107(6):1357-65. ,[object Object],[object Object]

Neuroprotection

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Neuroprotection