The document summarizes a presentation on challenges facing healthcare systems and opportunities for innovation through bioconvergence. It discusses major challenges like rising costs and an aging population with more chronic diseases. This is driving interest in integrated care models and technologies that can help manage health more efficiently. The presentation promotes Switzerland's biocluster as a unique hub bringing together academic research and industry to drive medical innovation through cross-sector collaboration and translation of new technologies from labs to market.
2. HEALTH CARE
“Medical revolution and new technologies”
The challenges
Towards bioconvergence
Our contribution
Anticipate the Future
3. HEALTH CARE
“Medical revolution and new technologies”
The challenges
Towards bioconvergence
Our contribution
Anticipate the Future
4. Crossing Visions
19/09/14 | 4
MAJOR CHALLENGES
IN HEALTHCARE
Therapeutic challenges
Demographics
Cost
Access
Variation in clinical practice
Inefficient use of information
Fragmented care versus integrated care
Duplication, defensive medicine & waste
Protracted adoption of innovation
6. DEMOGRAPHICS:
WE LIVE
LONGER
2
Crossing Visions
19/09/14 | 6 Life Expectancy at Birth
CH: 84.7
1900 1950 2010 2050
Benchmark:
Life expectancy in imperial Rome was ~ 30 years
CH: 80.5
Age 60 – 2 Billion
Age 80 – 380 Million
Age 100 – 2 Million
8. Crossing Visions
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THE BURDEN OF
CHRONIC DISEASES
Healthcare
spending for people
with chronic
conditions
Nearly half of us will have
chronic conditions
by 2030:
Diabetes
Neurodegenerative Disease
Obesity
Hypertension
Arthritis
Atherosclerosis
Stroke
Cancer
Degenerative Joint disease
Degenerative Spine Disease
Obstructive Lung Disease
Healthcare
spending for people
without chronic
conditions
Chronic conditions
account for 83%
of health care
4spending
10. Crossing Visions
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TOWARD
HEALTHIER
LIFE
Past model
Healthy life
Present model
Healthy life
Compressed morbidity model
Disease
Disability
Disease
Disability
Healthy life DiseLaisfee years gained
Disability
11. Click to edit Master title style
MEDTECH
“Medical revolution and new technologies”
The challenges
Towards Bioconvergence
Our contribution
Anticipate the Future
11.6.2013 IBM Technology Day 2013, Keynote B. Dubuis 11
12. Crossing Visions
19/09/14 | 12
CHANGING FOCUS
ON HEALTH CARE
Technology convergence
Pharmacogenomics
3P medicine
Translational medicine
Wireless Health
19. What is a Stent
A small, mesh-like device made of metal
Acts as a support or scaffold, in keeping the vessel open
Stent helps to improve blood flow to the heart muscle and reduce
the pain of angina
80% of patients who have balloon angioplasty will have a stent
placed as well.
20. History
Percutaneous transluminal coronary angioplasty (PTCA) by
Gruntzig in 1977
Puel and Sigwart, in 1986, deployed the first coronary stent to act
as a scaffold
In 2001, drug-eluting stents (DES) were introduced as a strategy
to minimize restenosis
21. Types
Bare metal stents:
Traditional method
May have an increased rate of
re-narrowing due to growth of scar
tissue in the stent, a condition called
Restenosis.
Drug-eluting
stents:
Combat Restenosis
Coated with medications that are slowly released
to block the body's ability to form scar tissue
around the stent. The medication is delivered
directly to the site of the artery blockage.
22. Click to edit Master title style
MEDTECH
“Medical revolution and new technologies”
The challenges
Towards an integrated health system
Our contribution
Innovation: The New Currency of
Competition
11.6.2013 IBM Technology Day 2013, Keynote B. Dubuis 23
25. Access to tools and knowledge
'evolutionary developmental biology'
Electronic health record'
1/30/2014 www.republic-of-innovation.ch Dr. B. Dubuis 26
26. The shift to patient-empowering, information-leveraging
technologies
“PI” (patient-empowering and information-leveraging) technologies
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27. Genomic & physiology
Molecular and personalized medicine
Proficient use of Information (e.health)
Access, Cost and Quality of care
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28. INNOVATION
The New Currency of Competition
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29. EXPLORE
NEW AVENUES
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30. WHERE
Towards
HISTORY WRITES
Campus Biotech
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31. WHERE
ENSURING THAT
HISTORY HISTORY GOES WRITES
ON
1/30/2014 www.republic-of-innovation.ch Dr. B. Dubuis 33
38. Click to edit Master title style
MEDTECH
“Medical revolution and new technologies”
The challenges
Towards an integrated health system
Our contribution
Anticipate the Future
11.6.2013 IBM Technology Day 2013, Keynote B. Dubuis 40
40. Crossing Visions
19/09/14 | 42
Support the growth
Anticipate the Future
Vitesse moyenne de croissance annuelle 95-00, 00-06
Source: BAK, Basel Economics
41. A Successfull biocluster
Established
access to Capital
Experienced
Business and
Law Firms
Carve-Outs/
Spinouts
Experienced
Entrepreneur Innovation
Initiatives
World-Class
Research
Institutions
World-Class
Business Schools
Experienced
Technical People
IP
Create Value
around IP
PhD’s
MBA’s
Early-Stage
Company
Late-Stage
Emerging/Public
Public
Industry Leader
C://DUBUIS, 2009
1/30/2014 www.republic-of-innovation.ch Dr. B. Dubuis 43
Charting the shift The accompanying chart shows several existing technologies clustered along two dimensions: whether they are providercontrolled or patient-empowering (on the vertical axis) and the extent to which they are information-leveraging (on the horizontal axis). Historically, the majority of medical technologies have not leveraged information. Some of these products have been targeted at patients (such as contact lenses and hearing aids — shown in Quadrant 2). Other products have been marketed to both patients and physicians (syringes, thermometers, bandages, etc.). But so far, the vast majority of medical technologies have been in Quadrant 1 — products that did not leverage information and were controlled by providers. More and more products are migrating away from Quadrant 1. In some cases, products have started leveraging information even though they are still under the control of providers (e.g., smart beds, which are remaking the lowly hospital bed into a device that can generate and track all sorts of useful health data). In other cases, the initial move was to become more patientempowering even though products still did not leverage information (e.g., traditional blood-pressure cuffs). Over time, however, many of these products will end up squarely in Quadrant 4 — effectively becoming PI technologies. While the blood-pressure monitors that initially moved into patients’ hands may not have been information-leveraging, the most recent iterations certainly are. Indeed, entire classes of diagnostic equipment — from blood-pressure monitors to glucometers and the aforementioned Cardiio heart-rate monitor — are being reinvented in radically patient-friendly ways. Many of these technologies are minimally invasive, compatible with consumer technologies such as smartphones and tablets, and allow patients to track, analyze and learn from their own data. Apnea monitors, for instance, have long been information-leveraging, but they were entirely controlled by providers. Now, sensor-embedded consumer devices such as the Zeo Sleep Manager allow patients to monitor their sleep every day. This gives apnea patients not only ownership over their data, but also more useful data — information that is generated in real-world conditions and provides a longitudinal panel from which to extract true insights into the behaviors and factors that exacerbate one’s ailment. The movement is gaining steam. While many categories of products will likely always remain in hospitals or under the control of physicians, in other categories — diagnostics, monitoring equipment, even some types of imaging products — we are likely to see more and more products empowering patients and leveraging information. The shift is likely to be accelerated not just by the pace of technological innovation, but also by the huge challenges facing health care and the fact that PI technologies can play a critical role in addressing these challenges.