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Reverse Innovation in Global Health and Development
- 2. “What unifies all forms of creative capitalism is that they are market-driven efforts to bring solutions we take for granted to people who can't get them.” — Bill Gates Slide 2www.globalgood.com © 2017 All rights reserved
- 3. No one has a monopoly on innovation. Great ideas can come from rich and poor areas alike ‒ and provide benefit to both. Slide 3www.globalgood.com © 2017 All rights reserved
- 4. Slide 4www.globalgood.com © 2017 All rights reserved • Inventing for challenging physical environments can result in more robust products for all environments • Usability enables operation by greater number of health workers • Partner distribution agreements leverage market forces to support scalability and sustainability Reverse Innovation Solutions to developing-world needs can deliver value to all economies worldwide
- 5. Untapped potential for invention Booz & Company’s “Global Innovation 1000” G-FINDER’s 34 Neglected Diseases $600B TOTAL R&D Healthcare $130B Computer & Electronics $170B $3B TOTAL R&D HIV/TB/Malaria $2.1B
- 6. INVENTING FOR THE BOTTOM BILLION
- 7. Hundreds of thousands of preventable deaths not prevented 20% of vaccines spoil before delivery
- 14. Like a Pregnancy Test, But More Powerful • As clinically sensitive as PCR • Asymptomatic malaria • TB detection from urine • Quantitative results • Made and distributedby the suppliersof current test strips, at similar cost
- 16. Guiding the Polio Campaign in Nigeria Upfill-Brown et al., BMC Medicine 2014
- 17. Partnering for Invention Government, Multilateral NGO and Commercial Sectors Late stage Execution Invention Technology Development Product Development Piloting Clinical and Field trials Manufacturing Capacity Sales Marketing Distribution Early stage High risk
- 18. AI Based Microscopy “Smart microscope” makes the gold-standard of malaria diagnosis accessible to all • Trained to recognize malaria parasites • Machine learning was based on millions of actual sample slides • Can diagnose malaria as accurately as the best trained expert microscopist • Also being trained to detect other pathologies Slide 18www.globalgood.com © 2017 All rights reserved
- 19. Improving Oxygen Delivery to Infants • O2 is key therapy for pediatric pneumonia, the leading cause of death in children in the poorest 75 countries • Oxygen delivery is often interrupted due to lack of power • We invented new systems that can double duration of oxygen delivery, bridging most power failures • To test new designs, we generated scale models based on actual face and respiratory cavities CT scans for thousands of children Slide 19www.globalgood.com © 2017 All rights reserved
- 20. THANK YOU
Editor's Notes
- To date, the tremendous power of invention has been focused on transforming lives that don’t really need to be transformed. In 2011, Booz & Co. estimated that the top 1000 publicly-listed R&D spenders spent roughly $600B. That included $170B just within the computer and electronics industry. In contrast, G-FINDER estimated that just $3B was spent that same year on R&D for the 34 diseases they classify as neglected. The majority of that went toward HIV, TB & malaria. It’s not just a funding issue, though, it’s a question of where our collective brainpower is focused. Booz & Co; http://www.booz.com/global/home/what-we-think/global-innovation-1000 (1000 Largest publicly listed R&D spenders) G-FINDER: http://www.policycures.org/downloads/GF2012_Report.pdf
- Here’s another problem we tackled that illustrates the necessity of sometimes accepting failure and moving on.
- When we went to Uganda to understand how vaccines are actually stored and transported in this part of the world, it wasn’t hard to see the problem.
- So after about five years of trials and a lot of error, we came up with this vaccine carrier, which can keep vaccines cold for months without power, and even track the entire temperature history of the content. It is now being manufactured by a spin-off of ours named Arktek.
- We’re confident it’s going to succeed because we took each of our earlier prototypes into the field and saw them fail in every conceivable way. And we learned what not to do from each of those failures. So when we took this model to field trials, people used it, they liked it--it just worked.
- Senegal 2013 with several of our partners from PATH and the ministry of health
- • Malaria is a tough target to spot -- few people in the world can do it accurately. • Identifying malaria parasites via microscope is equivalent to finding a handful of marbles in a football field. • Using machine learning, our scientists and algorithm experts ‘trained’ a microscope to recognize malaria parasites in a blood smear. • This “smart microscope” technology can provide all health workers with gold standard diagnosis of Malaria (and other diseases to follow).
- Millions die annually from problems that science and technology can potentially solve. We’re working to create affordable, accessible, appropriate solutions. Unlike traditional corporate charity, our innovations are powered by market demand; Our business model harnesses marketplace incentives for long-term sustainability. We team with leading humanitarian organizations, forward-looking governments, and commercial partners who share our vision.