Where do vesicles come from? A. Plasma membrance B. Nuclear membrance C. Smooth ER D. Lysosome Solution Where do vesicles come from? Ans-(A) Plasma membrane Vesicles are created by the cell from a portion of its own cell membrane fatty acids that are assembled by the Golgi body, membrane bound and secreted proteins are made on ribosomes found in the rough endoplasmic reticulum..