Similar to Preventing blindness with damaged cells studies; and how the location and histone code influence in Epigenomics. Molecular biology folding. (18)
Preventing blindness with damaged cells studies; and how the location and histone code influence in Epigenomics. Molecular biology folding.
1. Preventing blindness with damaged
cells studies; and how the location
and histone code influence in
Epigenomics.
Camilo Arias Rodríguez
Medical student.
4. Introduction
Epigenetics: Non genetic factors
influencing DNA structure.
Eye as a focus of degenerative
diseases, leading to blindness.
Research as a way to understand,
solve and improve.
5. Mohammad Haeri, Barry E. Knox,
Aphrodite Ahmadi.Modeling the
Flexural Rigidity of Rod
Photoreceptors.Biophysical Journal,
2013; 104 (2): 300 DOI:
7. Closer eye cell structure.
Discs of the outer segment
are vulnerable to damage
and breakage (mutations).
Because of rhodopsin high
concentration.
8. High density bands High rhodopsin concentration
Vulnerable to damage and
Low density bands breakage.
Average rhodopsin Degenerative diseases
Flexible and
concentration can lead easily to
steady.
blindness.
9. Student comment
I think the mutation in the
photoreceptors discs,
can be used as a
diagnosis help, to define
how many risks does a
patient have to turn
blind.
10. Menzies Chen, Katherine Licon, Rei
Otsuka, Lorraine Pillus, Trey
Ideker. Decoupling Epigenetic and
Genetic Effects through Systematic
Analysis of Gene Position.Cell Reports,
2013; DOI: 10.1016/j.celrep.2012.12.003
11. - Histones are the basic
component of the
chromatin.
- Both DNA and
histones, define the
landscape of certain
genes.
12. Epigenetic Alteration
Mix of histones Gene identity in genes
material
expresion.
13. - It was made a prove which consisted on inserting the gene in different
locations of chromatine.
- Experimental model: Yeast chromosome 1.
14. Student comment.
I consider epigenomics help
us to discover how can the
environment affect some
genes expression, and how
can they produce a
mutation, giving us tools to
prevent those diseases
15. Medical utility
Student comment.
New theory
We’ll be able to understand
easier the causes of retinal and
eye diseases in general, and
their development.
16. Medical utility
Student comment. New theory
New treatments and cures based
on the theory of the high
concentration of rhodopsin in
discs, will treat in a better way
patients with eye diseases,
evoiding getting blind.
18. Medical utility
Student comment.
New theory
Will help us understanding how genes
work, and to make a relation between their
location and themselves, and how can
diseases appear and work depending on
their chromatin ‘environment’.
19. •· [Http://sciencedaily.com/releases/2013/01/130103130756.htm] Checked
on January 29th of 2013, 22:50. “In Epigenomics, Location Is Everything:
Researchers Exploit Gene Position to test: ‘Histone Code’”
•· [http://sciencedaily.com/releases/2013/01/130122122403.htm] Checked on
January 29th of 2013, 22:32. “Study of How Eye Cells Become Damaged Could
Help Prevent Blindness:”
20. “Be determined, hug life and
live with passion.
Lose with class and win with
courage.
The World belongs to those who
face no fear and life is too
valuable to feel insignificant.”