2. Researchers developed retinal eye patch
made from human embryonic stem cells to
treat age-related macular degeneration.
Researchers grew retinal pigment epithelial
cells from stem cells and used synthetic
basement membrane to create retinal patch.
Phase 1 clinical trial findings are reported in
the journal Nature Biotechnology.
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3. Age-related macular degeneration is the
most common cause of visual impairment in
the developed world. This condition usually
affects people over 50 years. Age-related
macular degeneration affects central vision.
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4. The phase 1 study investigated if the stem cell
patch could restore vision by regenerating disease
cells. They surgically implanted the stem cell
retinal patch into the eye of two subjects. Results
showed noted improvement in vision over 12
months.
Further testing using biomicroscopy and optical
coherence tomography showed that stem cell
retinal patch survived. To prevent tissue rejection
they had to use local immunosuppression.
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5. Reference: Cruz, Lyndon Da, Kate Fynes, Odysseas Georgiadis, Julie Kerby,
Yvonne H. Luo, Ahmad Ahmado, Amanda Vernon, Julie T. Daniels, Britta
Nommiste, Shazeen M. Hasan, Sakina B. Gooljar, Amanda-Jayne F. Carr, Anthony
Vugler, Conor M. Ramsden, Magda Bictash, Mike Fenster, Juliette Steer, Tricia
Harbinson, Anna Wilbrey, Adnan Tufail, Gang Feng, Mark Whitlock, Anthony G.
Robson, Graham E. Holder, Mandeep S. Sagoo, Peter T. Loudon, Paul Whiting, and
Peter J. Coffey. "Phase 1 Clinical Study of an Embryonic Stem Cell–derived
Retinal Pigment Epithelium Patch in Age-related Macular Degeneration." Nature
Biotechnology, 2018. doi:10.1038/nbt.4114.
For more info please visit “Age-related macular
degeneration treated with a stem cell retinal patch”
article at www.medicalnewsobserver.com
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