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2020
SCHEDULE
HOUSEKEEPING ITEMS
▸ Breaks
▸ CME / CMU
▸ Handouts/Slides:
▸ Symposium link @ sparcctucson.com
▸ Question format
2020 UPDATES IN
CONCUSSIONMO MORTAZAVI, MD
MEDICAL DIRECTOR, SPARCC
MEDICAL DIRECTOR, TUSD INTERSCHOLASTICS
NO FINANCIAL DISCLOSURES
TEXT
OBJECTIVES
▸ Case review
▸ Consensus Summaries
▸ Evidence-based updates
▸ Concussion phenotypes (sub-typing)
▸ Updates in targeted subtype management
CASE 1
▸13 y/o healthy boy with elbow to head
▸No LOC, some HA and dizziness
▸Assessed and had not ‘red flags’
▸Continues with regular school activities
▸Reports ongoing worsening HA and new Migranes
CASE 1— AT 4 WEEKS
▸Sees neurologist and starts on Topimax
▸Normal MRI brain
▸Symptoms continue to progress
▸No longer tolerating sports or exercise
▸Struggling with academics
▸Depressed, hopeless
CASE 1 — AT 3 MONTHS
▸Seen at SPARCC at 3 months
▸Ongoing severe:
▸Cognitive deficits
▸Exercise intolerance
▸Cervical dysfunction and migraines
WHAT NOW??
:(
MYTHS
▸“Its just a concussion, you’ll be ok in a few days”
▸“No LOC or big hit == no concern”
▸“Normal MRI/CT means you’re good”
▸“Concussions don’t last more than 2 weeks”
▸“Its just your migraines”
▸“Its all in your head, you are just depressed”
TEXT
BACKGROUND
▸ Estimated 2-4 million concussions per year
▸ 75-90% of concussions in sports DO NOT
involve loss of consciousness
▸ Females have higher rate than males in same
sports
CONCUSSION
NO UNIVERSAL
DEFINITION
▸ Characterized by immediate and transient post-
traumatic impairment of neural function due do
CNS involvement
CONCUSSION
Trauma to the brain
Impairment in normal brain function because
due to chemical alteration
Disturbance in the normal pathways in the
neurons
Increased symptoms with daily activities
CONCUSSION
TIMELINE
▸ Symptoms resolve in 10-14d (adults)
▸ Longer with adolescents (2-3 wks)
▸ ~30% have prolonged symptoms (PPCS)
▸ > 4 wks should prompt referral
CUMULATIVE EFFECT OF
MULTIPLE CONCUSSIONS?▸ Prolonged recovery
▸ Lower Concussion threshold
PRESENTATION
▸Multiple manifestations
▸Every instance is unique
▸Physical symptoms
▸Cognitive symptoms
▸Psychiatric / Behavioral symptoms
EMERGENT CT SCAN?
RED FLAGS
▸ Any neurological deficits
▸ History of prolonged LOC (>30 sec)
▸ Deterioration of symptoms
▸ Severe headache (9-10/10)
▸ Persistent Confusion or AMS
▸ Seizure
▸ Suspicion of Skull Fracture
TEXT
CONSENSUS SUMMARIES
▸ Avoid routine CTs
Multidisciplinary Functional Testing
▸ Validated tools
Scat5/ImPACT/VOMS
▸ PPCS up to 30%
Refer after 4 weeks
ID PPCS Risk Factors
▸ Avoid absolute rest > 2-3d
Customized RTL
Active Rehab
▸ Rehab > Meds !
Exertional Rehab
Vestibulo-ocular Rehab
Cervical Rehab
TEXT
CONSENSUS ON
MANAGEMENT
▸ Research supports multi-disciplinary therapeutic approach and
Early Intervention
Return to learn and cognitive support
Return to play protocol
Vestibulocular Rebab
Cervical Rehab
Graded Exertional Rehab
TEXT
NO FDA-APPROVED MEDICATIONS FOR
CONCUSSION
Rehab > Meds
WHAT’S NEW
MODERN EVIDENCE-
BASED CONCEPTS▸ Prolonged symptoms
Variety of PPCS stages
Predictors of PPCS
▸ Earlier Intervention
Better outcomes / time to recovery
▸ Evidence for ongoing injury
Structure vs Function (VOMS / Cog Test)
Macrostructure vs Microstructure
▸ Concussion Sub-typing!
0.00% 10.00% 20.00% 30.00% 40.00%
Mixed
Visual
Cervical
Mood
Headache
Vestibular
Cognition
Value Title
Figure 2: Subtype Frequency per Stage
1-3% 4/4P%
0
6%
1
31%
2
25%
3
23%
4
11%
4P
4%
Mixed
Visual
Cervical
Mood
Headache
Vestibular
Cognition
TEXT
PREDICTORS OF MORBIDITY
▸ Early Risk factors for prolonged symptoms
Severity of initial symptoms
Migrane type HA (photo/phono)
Dizziness, VOMS +
Psychiatric/Sleep co-morbidity
Delayed Care
Severe Vision Deficits!
TEXT
EARLY INTERVENTION
▸Removal from play
▸Immediate frontline Care
▸ASAP Concussion care (SCAT5, VOMS, Cog)
▸Early Rehabilitative Management
Lower Risk of PPCS
Decreased Symptom Burden
Faster Recovery
8.8x more likely to have protracted recovery
TEXT
EVIDENCE OF PERSISTENT INJURY
▸ Most commonly persistent FUNCTIONAL impairments
Cognitive (ImPACT, NP Testing)
Vestibulo-ocular (Balance, Eye testing)
Neurophysiology (qEEG/Evoked potentials)
Neurometabolic
▸ Micro-structural injury to white matter on DTI
TEXT
CO-MORBIDITY VS INJURY
▸There is often overlap
▸Co-morbidities create predispositions to injury and longer recoveries
▸Baseline weakness are more prone to get weaker (compare symptoms to
baseline)
▸Objective testing can help determine persistent injury vs baseline co-morbidity
PROFILES & SUBTYPES
KONTOS, UPMC 2020
CP SCREEN
▸High validity and reliability (ICC 0.91)
▸Concurrent high validity w/ PCSS, VOMS, IMPACT
▸High predictive validity injury
▸Highest VOMS correlation with vestibular and ocular domains
▸Highest Impact correlation with cognitive subtype
Subtype Specific
TEXT
SUBTYPES
TEXT
▸Migrane: 35%
▸Mood: 19%
▸Vestibulo-ocular: 25%
TEXT
SUBTYPE SUMMARIES
▸Migraine and mood most common (VOM)
▸Good inter-rater reliability agreement across profiles….
▸Not as good as ranking them
▸Future of concussion is targeted management for subtypes (not “protocol” for all)
SUBTYPES
DEFINING PHENOTYPES
TEXT
RISK FACTORS
OUR VERSION / RESEARCH REFERENCES
TEXT
UPDATED TARGETED MANAGEMENT
▸Migraine-CGRP 3 agonists and biomarkers
▸Exercise intolerance - new protocols for ARP testing/management
▸Vision-NOR, VEP, orhoptics/prisms
▸Cognitive - Rehab / medications
▸Mood / Sleep - CBT, Blue Light
▸Cervical - PT, Graston, Trigger point, CST
KEY references:
● 5th Consensus
● SCAT 5 assessment tool
● CDC/AAP/AMSSM
● VOM Screening tool (UPMC)
● Sub typing/Clinical Trajectories
● CP tool (UPMC)
● Our website:
References:
1. 5th Consensus Statement on Concussion in Sport. BJSM
April 2017.
2. Mucha, AM etal. A Brief Vestibular/Ocular Motor Screening
(VOMS) Assessmentto Evaluate Concussions: Preliminary
Findings. Investigation performed at the University of
Pittsburgh, Pittsburgh, Pennsylvania, USA. 2014.
3. Pediatric Sport-Related Concussion: A Review of the Clinical
Management of an Oft-Neglected Population. Kirkwood MW,
Yeates KO, Wilson PE. Pediatrics. April 2006; 1359-1371.

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Conc symposium 2020

  • 3. HOUSEKEEPING ITEMS ▸ Breaks ▸ CME / CMU ▸ Handouts/Slides: ▸ Symposium link @ sparcctucson.com ▸ Question format
  • 4. 2020 UPDATES IN CONCUSSIONMO MORTAZAVI, MD MEDICAL DIRECTOR, SPARCC MEDICAL DIRECTOR, TUSD INTERSCHOLASTICS
  • 6. TEXT OBJECTIVES ▸ Case review ▸ Consensus Summaries ▸ Evidence-based updates ▸ Concussion phenotypes (sub-typing) ▸ Updates in targeted subtype management
  • 7. CASE 1 ▸13 y/o healthy boy with elbow to head ▸No LOC, some HA and dizziness ▸Assessed and had not ‘red flags’ ▸Continues with regular school activities ▸Reports ongoing worsening HA and new Migranes
  • 8. CASE 1— AT 4 WEEKS ▸Sees neurologist and starts on Topimax ▸Normal MRI brain ▸Symptoms continue to progress ▸No longer tolerating sports or exercise ▸Struggling with academics ▸Depressed, hopeless
  • 9. CASE 1 — AT 3 MONTHS ▸Seen at SPARCC at 3 months ▸Ongoing severe: ▸Cognitive deficits ▸Exercise intolerance ▸Cervical dysfunction and migraines WHAT NOW??
  • 10. :( MYTHS ▸“Its just a concussion, you’ll be ok in a few days” ▸“No LOC or big hit == no concern” ▸“Normal MRI/CT means you’re good” ▸“Concussions don’t last more than 2 weeks” ▸“Its just your migraines” ▸“Its all in your head, you are just depressed”
  • 11. TEXT BACKGROUND ▸ Estimated 2-4 million concussions per year ▸ 75-90% of concussions in sports DO NOT involve loss of consciousness ▸ Females have higher rate than males in same sports
  • 12. CONCUSSION NO UNIVERSAL DEFINITION ▸ Characterized by immediate and transient post- traumatic impairment of neural function due do CNS involvement
  • 13. CONCUSSION Trauma to the brain Impairment in normal brain function because due to chemical alteration Disturbance in the normal pathways in the neurons Increased symptoms with daily activities
  • 14.
  • 15. CONCUSSION TIMELINE ▸ Symptoms resolve in 10-14d (adults) ▸ Longer with adolescents (2-3 wks) ▸ ~30% have prolonged symptoms (PPCS) ▸ > 4 wks should prompt referral CUMULATIVE EFFECT OF MULTIPLE CONCUSSIONS?▸ Prolonged recovery ▸ Lower Concussion threshold
  • 16. PRESENTATION ▸Multiple manifestations ▸Every instance is unique ▸Physical symptoms ▸Cognitive symptoms ▸Psychiatric / Behavioral symptoms
  • 17.
  • 18. EMERGENT CT SCAN? RED FLAGS ▸ Any neurological deficits ▸ History of prolonged LOC (>30 sec) ▸ Deterioration of symptoms ▸ Severe headache (9-10/10) ▸ Persistent Confusion or AMS ▸ Seizure ▸ Suspicion of Skull Fracture
  • 19.
  • 20. TEXT CONSENSUS SUMMARIES ▸ Avoid routine CTs Multidisciplinary Functional Testing ▸ Validated tools Scat5/ImPACT/VOMS ▸ PPCS up to 30% Refer after 4 weeks ID PPCS Risk Factors ▸ Avoid absolute rest > 2-3d Customized RTL Active Rehab ▸ Rehab > Meds ! Exertional Rehab Vestibulo-ocular Rehab Cervical Rehab
  • 21. TEXT CONSENSUS ON MANAGEMENT ▸ Research supports multi-disciplinary therapeutic approach and Early Intervention Return to learn and cognitive support Return to play protocol Vestibulocular Rebab Cervical Rehab Graded Exertional Rehab
  • 22. TEXT NO FDA-APPROVED MEDICATIONS FOR CONCUSSION Rehab > Meds
  • 23. WHAT’S NEW MODERN EVIDENCE- BASED CONCEPTS▸ Prolonged symptoms Variety of PPCS stages Predictors of PPCS ▸ Earlier Intervention Better outcomes / time to recovery ▸ Evidence for ongoing injury Structure vs Function (VOMS / Cog Test) Macrostructure vs Microstructure ▸ Concussion Sub-typing!
  • 24.
  • 25. 0.00% 10.00% 20.00% 30.00% 40.00% Mixed Visual Cervical Mood Headache Vestibular Cognition Value Title Figure 2: Subtype Frequency per Stage 1-3% 4/4P% 0 6% 1 31% 2 25% 3 23% 4 11% 4P 4% Mixed Visual Cervical Mood Headache Vestibular Cognition
  • 26. TEXT PREDICTORS OF MORBIDITY ▸ Early Risk factors for prolonged symptoms Severity of initial symptoms Migrane type HA (photo/phono) Dizziness, VOMS + Psychiatric/Sleep co-morbidity Delayed Care Severe Vision Deficits!
  • 27. TEXT EARLY INTERVENTION ▸Removal from play ▸Immediate frontline Care ▸ASAP Concussion care (SCAT5, VOMS, Cog) ▸Early Rehabilitative Management Lower Risk of PPCS Decreased Symptom Burden Faster Recovery
  • 28. 8.8x more likely to have protracted recovery
  • 29. TEXT EVIDENCE OF PERSISTENT INJURY ▸ Most commonly persistent FUNCTIONAL impairments Cognitive (ImPACT, NP Testing) Vestibulo-ocular (Balance, Eye testing) Neurophysiology (qEEG/Evoked potentials) Neurometabolic ▸ Micro-structural injury to white matter on DTI
  • 30.
  • 31.
  • 32. TEXT CO-MORBIDITY VS INJURY ▸There is often overlap ▸Co-morbidities create predispositions to injury and longer recoveries ▸Baseline weakness are more prone to get weaker (compare symptoms to baseline) ▸Objective testing can help determine persistent injury vs baseline co-morbidity
  • 34.
  • 35.
  • 36.
  • 37. KONTOS, UPMC 2020 CP SCREEN ▸High validity and reliability (ICC 0.91) ▸Concurrent high validity w/ PCSS, VOMS, IMPACT ▸High predictive validity injury ▸Highest VOMS correlation with vestibular and ocular domains ▸Highest Impact correlation with cognitive subtype Subtype Specific
  • 40.
  • 41. TEXT SUBTYPE SUMMARIES ▸Migraine and mood most common (VOM) ▸Good inter-rater reliability agreement across profiles…. ▸Not as good as ranking them ▸Future of concussion is targeted management for subtypes (not “protocol” for all)
  • 44.
  • 45. OUR VERSION / RESEARCH REFERENCES
  • 46. TEXT UPDATED TARGETED MANAGEMENT ▸Migraine-CGRP 3 agonists and biomarkers ▸Exercise intolerance - new protocols for ARP testing/management ▸Vision-NOR, VEP, orhoptics/prisms ▸Cognitive - Rehab / medications ▸Mood / Sleep - CBT, Blue Light ▸Cervical - PT, Graston, Trigger point, CST
  • 47.
  • 48. KEY references: ● 5th Consensus ● SCAT 5 assessment tool ● CDC/AAP/AMSSM ● VOM Screening tool (UPMC) ● Sub typing/Clinical Trajectories ● CP tool (UPMC) ● Our website:
  • 49. References: 1. 5th Consensus Statement on Concussion in Sport. BJSM April 2017. 2. Mucha, AM etal. A Brief Vestibular/Ocular Motor Screening (VOMS) Assessmentto Evaluate Concussions: Preliminary Findings. Investigation performed at the University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 2014. 3. Pediatric Sport-Related Concussion: A Review of the Clinical Management of an Oft-Neglected Population. Kirkwood MW, Yeates KO, Wilson PE. Pediatrics. April 2006; 1359-1371.