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- 2. BioGenesisThe Euro-India Health Cluster Cluster ::: • The combinaison in a defined geographic area • Of entreprises (industries & SMEs), training and research entities (public or private) • Engaged in a synergy of innovative common projects • Targeting a market related to a technology and scientific domain • With animation and networking • A strong governance
- 3. BioGenesisThe Euro-India Health Cluster Functional entity: the Project ::: • The main target of Competitiveness Cluster is to initiate, help for the preparation, validate and find a financing for R & D projects • Main criteria – Projects associating public and private R & D – Project managed by a company based in the region – Evaluation made by external experts to assess economical and scientific potential
- 4. BioGenesisThe Euro-India Health Cluster Objectives::: • Aims are to: – Develop employement and economy – Reach a critical volume – Increase visibility and international lisibility – Improve attractiveness of the territory • But also… – to develop international partnership – To attract international investors – To potentiate export capabilities of members
- 6. BioGenesisThe Euro-India Health Cluster 5 villes 2 régions Immunology & therapeutic applications Eldely, neurological diseases and handicap: Research and Care Infectious, Tropical & Emerging Diseases Rare and Orphan Diseases Medical Devices, bio-markers and diagnosis Axes Zones Training 39 000 students 1 500 PhD INDUSTRIES > 200 companies 10 000 direct jobs 3 000 jobs R&D RESEARCH 220 labs, 6 000 rechearchers Labels Génopole, Canceropole Infectiopole, DIRC… Prod’Innov Santé B O R D E A U X Aliments et santé Medicen Alsace Biovalley EuroBioMed
- 7. BioGenesisThe Euro-India Health Cluster Main industrial partners::: NîmesMontpellier Marseille Nice Toulon Marcoule / Vergèze La Ciotat Sophia-Antipolis La Seyne sur Mer
- 10. BioGenesisThe Euro-India Health Cluster • 322 projects have been assessed, 263 of them have been approved 18 37 56 59 91 8 6 17 11 19 0 20 40 60 80 100 120 2006 2007 2008 2009 2010 Non approved Approved Projects evaluated & approved::: July 2010
- 11. BioGenesisThe Euro-India Health Cluster Projects approved & financed::: • 74 projects have been financed in the frame of Eurobiomed in 4 years 3 0 0 4 5 2 0 0 3 11 1 1 5 12 2 2 2 16 0 2 4 6 8 10 12 14 16 2006 2007 2008 2009 2010 FUI ANR Oseo FP7 IMI & ISI ARCUS Nbofprojects
- 13. BioGenesisThe Euro-India Health Cluster EFPIA Company Principle Investigator Institution Principle Investigator Astra Zeneca Hans-Goran Hardemark University of Marseille Olivier Blin Boehringer-Ingelheim Bernd Sommer IDIBAPS David Bartres-Faz Novartis Georges Imbert University of Lille Régis Bordet Servier esther.schenker University of Leipzig Peter Schonknecht UCB Yves Lamberty University of Murcia Maria-Trinidad Herrero Spitzer Merck Serono Dirk Beher University of Essen Philipp Spitzer Lilly Michael J O'neill CNRS Fabienne Aujard Janssen John Atack INSERM Pierre Payoux Roche Susanne Ostrowitzki University of Verona Marina Bentivoglio Lundbeck Jan Egebjerg IRCCS-FBF Giovanni Frisoni GSK Elaine Irving UNIFG Claudio Babiloni Mario Negri Institute Gianluigi Forloni AlzProtect Philippe Verwaerde Qualissima Severine Pitel ExonHit Pascale Beurdeley Innovative Health Diagnostics Xavier Regnaut AlzhiimerEurope Jean Georges Innovative Concepts in Drug Design Nathalie Compagnone Advancing science and treatment of Alzheimer’s Disease Contribution EFPIA : 10.6 M€ Contribution IMI JU : 9.6 M€ Matrix development strategy Cellular Therapeutic Challenge Phase II Phase Ia/Ib GO/NOGO Biology Electrophysiology Psychophysiology Imaging Animal HV Selected Patient x y z Total Budget : 30 M€
- 14. BioGenesisThe Euro-India Health Cluster International::: • International R&D projects • International collective actions • Meetings • Partnerships • Presence
- 15. 1 Virbac SA 2 Institut de Recherche pour le Développement – UMR177 3 Instituto de Salud Carlos III 5 Indian Council of Medical Research – Institute of pathology 6 Universidad Peruana Cayetano Heredia 7 Institut Pasteur de Tunis 8 Consulting Group 9 In progress FP7 sept. 2007 3,97 M€ total budget 2,74 M€ grants Amastigotes (Lemesre Jean-Loup, IRD) Leishmaniosis Vaccine
- 16. BioGenesisThe Euro-India Health Cluster • Eurobiomed organised a mission with other Health Clusters during Bio-Bangalore in 2008 : – New-Delhi 21/04/08 – Hyderabad 22/04/08 – Bangalore 23 & 24/04/08 • 5 clusters participated: – Medicen (Ile-de-France) – Lyon Biopôle (Rhône Alpes) – Alsace Biovalley (Alsace) – Atlantic Biotherapies (Pays de Loire) – Eurobiomed (LR – PACA) : ADME, Qualissima,… Bio-Bangalore 2008:::
- 21. BioGenesisThe Euro-India Health Cluster Hyderabad Bio Industry ::: • Hyderabad is the financial, economic and political capital of the state of Andhra Pradesh. Hyderabad has a population of over 4 million. • Hyderabad is a major centre for pharmaceuticals: Dr. Reddy's Laboratories, Matrix Laboratories, Hetero Drugs Limited, Divis Labs, Aurobindo Pharma Limited, Lee Pharma and Vimta Labs. • Initiatives such as Genome Valley, Fab City and the Nano Technology park are expected to create extensive infrastructure in bio-technology. • Hyderabad is home to numerous research institutes, including the Indian Institute of Chemical Technology (IICT), Centre for Cellular and Molecular Biology (CCMB), Centre for DNA Fingerprinting and Diagnosis, National Institute of Nutrition (NIN) and International Crops Research Institute for Semi-Arid Crops (ICRISAT). • Hyderabad has number of renowned universities namely Hyderabad Central University, Osmania University, JNTU, etc. • Hyderabad is home to many superlative hospitals. Some of the leading hospitals include Apollo Hospitals, Care Hospitals, Global Hospitals, NIMS, etc.
- 22. BioGenesisThe Euro-India Health Cluster BioGenesis ::: BioGenesis is a Non Profit Organization set up to integrate the Healthcare Community in the City of Hyderabad and other cities in India and link it to the World Bioclusters, for mutually beneficial associations. We also aim: • To integrate and develop synergies between firms, laboratories, and training facilities setting up a network between interested organizations and develop partnership projects. • To develop new innovations in the health service., • To enhance the visibility within the national health sector as well as international health and life sciences industry. • To accompany the development of business and increase employment opportunities nationally.
- 24. BioGenesisThe Euro-India Health Cluster • A 12 year old company • Manufacturing facilities in Hyderabad, India • Denisco supplies cutting edge products in organic synthesis to Pharmaceutical, Agricultural and Specialty Chemical industries • Business split : 80% Europe/US/Japan, 20% India • Historical facility (1/2 acre) • New facility (17acres): 20MTs/month, Q2, 2011
- 25. BioGenesisThe Euro-India Health Cluster 25 §Created in 2004 §50 employees §High profile team members with experienced managers §Offices in Montpellier, Paris, Shanghai, Sao Paulo, Milan, Singapore & Budapest § Develops and markets Software Solutions to Visualise and Analyse Medical Images from all modalities (CT-Scan, MRI, PET, CR/DR, Ultrasound …) §Myrian Product offering includes Generic Applications and unique Expert Clinical Modules §Liver Module considered as the best in class on a worldwide basis §400 installations in 26 countries §Sales to Hospitals and Clinics, Medical Imaging Centers, Modality, Pacs & Ris vendors §Partnership with Toshiba for MRI workstations INTRASENSE a Medical Imaging Software Editor
- 26. BioGenesisThe Euro-India Health Cluster Asiatic Mediquipts Surat Hemal Joshi Yoga Pune Mahesh Pathak Sree Bhagavathy Agencies Kerala Mr.Subramoniam Access Devices Bangalore DV Ashok / Ramesh Shetty Silverline Specialities Hyderabad GSK Chakravarhy Sree Bhagavathy Agencies Chennai Mr.N.T.Srinivasan ModiMedicare Head Offices Mumbai Jigish Modi Krishna Micromed NewDelhi Alok Sinha Intrasense operates in India through 3 main channels: •One Distributor dedicated to high-end modules, Modimedicare established in Mumbai and covering India through 7 sub-distributors. Major hospitals (Apollo , Institute of Liver & Biliary Sciences, Medanta Hospitals, Asian Institute of Gastroenterology, AIMS….) and Medical Imaging Centers (Piramid, Jupiter, Astre Imaging….) have been already approached •One distributor , Komega, dedicated to generic application and Computer/Digital Radiology covering Tiers 3 hospitals (50 to 200 beds). •OEM Partneships with PACS and RIS companies. 2 agreements have been already signed with Moksha (a Pacs supplier from Bangalore) and Century21, (a Pacs/Ris supplier from Mumbai). •Drastic increase in the number of private imaging centers (CT, MRI, PET/CT) •Remote hospitals in a teleradiology mode. •Transplant surgery is now developing in more than 15 hospitals across the country (liver, lung and kidney) 26
- 27. BioGenesisThe Euro-India Health Cluster Synchron (India) and ADME (France) • SYNCHRON: – 12 years experience : one of the first CROs in India – 134 beds in Ahmedabad – Access to a large database of volunteers (over 7500) – Access to special populations : Post-menopausal women/ Cancer patients/ Diabetic patients (clamp studies)/ Renal impaired patients • Eurofins ADME BIOANALYSES: – 20 years experience in pharmacokinetics – 7 LC-MS/MS in France – Regularly inspected by AFSSAPS (every two years) and succesfully inspected by FDA in July 2009 • Common objective: – Conduct phase I to IV clinical trials, including bioequivalence studies with clinical trial in India and bioanalysis in France – First project started in September
- 28. BioGenesisThe Euro-India Health Cluster 28 At the crossroad of 3 major trends Growing importance of patient’s role Growing role of health authorities Process internationalisation Vision: •To be a centre of excellence in pharmaceutical research, training and healthcare provider underpinned by intellectual ability, •A strong worth ethic and a customer centric approach •A “showroom” for Indo-French-European collaborations in science and health (research, care, green architecture)Mission: •To create a Translational Research Institute within the next 3 years •To allow pharmaceutical companies and drug molecule to be taken from the ‘bench’ to the ‘bedside’ in a cost-effective and timely manner •To provide the highest international standard care
- 29. BioGenesisThe Euro-India Health Cluster Translational Medecine Platfom E-training Patient Web site Web platform Consulting Soft landing gateway 25 acres land Genome Valley Human Research Platform Biology Clinical Trials SMO Partners: -Care -Global -NIMS -Indo-Am CH -MNJ CH Partners: Univ Hyd CCMB IICT CDFD Institute of Genetics CRO Research Programs New Indigo BioGenesis Indo-European LifeSciences Competitiveness Cluster
- 32. The Future: Medical Devices ECRIN FP7 program, WP5 Medical Devices European Archipelago of Medical Device Marseille Provence Collaborative project dedicated to medical device and health technologies’ innovation and development Mutualized Technology Platforms Network of experts Services from conception to marketing Virtual simulation « Homme virtuel » Imaging Elderly Home Care From concept….to patient Medical Devices Indo-European One Stop Shop
- 36. BioGenesisThe Euro-India Health Cluster Immunology and therapeutic applications Treatment and care of ageing, neurological diseases and handicap Infectious, tropical and emerging pathologies Rare and orphan diseases Medical devices, biomarkers and diagnostic Axis 5 villes 2 régions Zonage EDUCATION 39 000 students 1 500 doctorates INDUSTRY > 200 companies 10 000 directs jobs 3 000 in R&D 5 cities 2 Regional Councils PUBLIC RESEARCH Public laboratories, > 6 000 researchers, Génopole Labels Canceropole, Infectiopole… Competitiveness cluster Eurobiomed
- 37. BioGenesisThe Euro-India Health Cluster Some projects financed by the "Fonds Unique Interministériel" • 2.7 M€ total budget • 1.4 M€ financing "Innovative anti Malaria therapies and Diagnostic" InnoMad • 5.8 M€ total budget • 3.9 M€ financing "Diagnosis and Treatment of Alzheimer disease" DiaTrAl • 14 M€ total budget • 5.5 M€ financing "New approach of screening" Cell2Lead
- 38. The target is to develop this field. There is also a big potential in the pharma business.