This document provides dosing guidelines for various antibiotics in pediatric patients. It includes formulas for calculating doses based on a child's age, weight, and the concentration of the antibiotic. Specific dosing ranges and schedules are provided for several common antibiotics like amoxicillin, ampicillin, cephalexin, erythromycin, and others. The guidelines cover dosing for both oral and parenteral antibiotic administration in infants and children.

1. Doses Of Antibiotics for pediatrics
‫ﺟﺮام‬ ‫ﺑﺎﻟﻜﯿﻠﻮ‬ ‫اﻟﻄﻔﻞ‬ ‫وزن‬) =‫ﺑﺎﻟﺸﮭﻮر‬ ‫اﻟﻄﻔﻞ‬ ‫ﻋﻤﺮ‬+9(÷2◄‫ﻣﻦ‬ ‫ﻟﻸﻃﻔﺎل‬3‫ـ‬12‫ﺷﮭﺮ‬
‫اﻟﻄﻔﻞ‬ ‫وزن‬ ‫ﺣﺴﺎب‬ ‫ﺟﺮام‬ ‫ﺑﺎﻟﻜﯿﻠﻮ‬ ‫اﻟﻄﻔﻞ‬ ‫وزن‬) =‫ﺑﺎﻟﺴﻨﺔ‬ ‫اﻟﻄﻔﻞ‬ ‫ﻋﻤﺮ‬×2(+8◄‫ﻣﻦ‬ ‫ﻟﻸﻃﻔﺎل‬1‫ـ‬6‫ﺳﻨﮫ‬
‫ﺑﺎﻟﻜﯿﻠﻮ‬ ‫اﻟﻄﻔﻞ‬ ‫وزن‬‫ﺟﺮام‬=})‫ﺑﺎﻟﺴﻨﺔ‬ ‫اﻟﻄﻔﻞ‬ ‫ﻋﻤﺮ‬×7(-5{÷2◄‫ﻣﻦ‬ ‫ﻟﻸﻃﻔﺎل‬7‫ـ‬12‫ﺳﻨﮫ‬
‫اﻟﯿﻮﻣﯿﺔ‬ ‫اﻟﺠﺮﻋﺔ‬)‫ﻣﻞ‬(=)‫اﻟﻮز‬‫ن‬() *‫ﻛﺠﻢ‬ ‫ﻟﻜﻞ‬ ‫اﻟﺠﺮﻋﺔ‬) * (‫اﻟﻤﺴﺘﺨﺪم‬ ‫اﻟﺘﺮﻛﯿﺰ‬ ‫ﯾﻤﺜﻞ‬ ‫ﻣﻞ‬ ‫ﻛﺎم‬) / (‫اﻟﺤﯿﻮى‬ ‫اﻟﻤﻀﺎد‬ ‫ﻣﻦ‬ ‫اﻟﻤﺴﺘﺨﺪم‬ ‫اﻟﺘﺮﻛﯿﺰ‬(
‫اﻟﻰ‬ ‫ﺗﻘﺴﻢ‬ ‫او‬ ‫واﺣﺪة‬ ‫ﻣﺮة‬ ‫ﺗﺆﺧﺬ‬ ‫ﻗﺪ‬ ‫اﻟﯿﻮﻣﯿﺔ‬ ‫اﻟﺠﺮﻋﺔ‬2-3‫ﺟﺮ‬‫اﻟﺤﯿﻮى‬ ‫اﻟﻤﻀﺎد‬ ‫اﺳﺘﺨﺪام‬ ‫ﺣﺴﺐ‬ ‫ﻋﺎت‬
‫اﻟﻤﺜﺎل‬ ‫ﺳﺒﯿﻞ‬ ‫ﻋﻠﻰ‬◄‫ﻃﻔﻞ‬10‫اﻣﻮﻛﺴﯿﺴﻠﻠﯿﻦ‬ ‫ﺳﯿﺘﻨﺎول‬ ‫ﻛﺠﻢ‬125‫ﻣﻠﺠﻢ‬/5‫ھﻰ‬ ‫ﺟﺮام‬ ‫ﻛﯿﻠﻮ‬ ‫ﻟﻜﻞ‬ ‫واﻟﺠﺮﻋﺔ‬ ‫ﻣﻞ‬25‫ﻣﺠﻢ‬
‫اﻟﯿﻮﻣﯿﺔ‬ ‫اﻟﺠﺮﻋﺔ‬ ‫اذا‬) =10*25*5/ (125=10‫ﯾﻌﺎدل‬ ‫ﺑﻤﺎ‬ ‫ﺟﺮﻋﺎت‬ ‫ﺛﻼث‬ ‫اﻟﻰ‬ ‫اﻟﺠﺮﻋﺔ‬ ‫ھﺬا‬ ‫وﺗﻘﺴﻢ‬ ‫ﻣﻞ‬3.3‫ﻛﻞ‬ ‫ﻣﻞ‬8‫ﺳﺎﻋﺎت‬
‫اﺳﺘﻨﺘﺎﺟﺎت‬◄)‫ھ‬‫ﺑﺎﻷﺷﺮﺑﺔ‬ ‫ﺧﺎﺻﺔ‬ ‫اﻻﺳﺘﻨﺘﺎﺟﺎت‬ ‫ﺬه‬(↓
‫ھﻰ‬ ‫اﻟﻤﺴﺘﺨﺪﻣﺔ‬ ‫اﻟﺠﺮﻋﺔ‬ ‫ﻛﺎﻧﺖ‬ ‫اذا‬25‫ﻣﻠﺠﻢ‬/‫ﻣﺒﺎﺷﺮة‬ ‫اﻟﻮزن‬ ‫ﻃﺮﯾﻖ‬ ‫ﻋﻦ‬ ‫اﻟﺠﺮﻋﺔ‬ ‫ﻧﺤﺴﺐ‬ ‫ان‬ ‫ﻓﯿﻤﻜﻨﻨﺎ‬ ‫ﻛﺠﻢ‬‫ﻓﻰ‬ ‫اﻟﺘﺮﻛﯿﺰات‬ ‫ﺟﻤﯿﻊ‬ ‫ﺗﺘﻤﺜﻞ‬ ‫ﺣﯿﺚ‬5‫ﻣﻞ‬
‫ﻟﺘﺮﻛﯿﺰ‬ ‫ﺑﺎﻟﻨﺴﺒﺔ‬ ‫اﻟﺠﺮﻋﺔ‬125‫ﻣﻠﺠﻢ‬/‫ﻛﺠﻢ‬=‫اﻟﻮزن‬‫اﻟﻄﻔﻞ‬ ‫وزن‬ ‫ﻟﻮ‬10‫اﻟﻤﺴﺘﺨﺪﻣﺔ‬ ‫اﻟﯿﻮﻣﯿﺔ‬ ‫اﻟﺠﺮﻋﺔ‬ ‫اذا‬ ‫ﻛﺠﻢ‬‫ھﻰ‬10‫ﻣﻞ‬
‫ﻟﺘﺮﻛﯿﺰ‬ ‫ﺑﺎﻟﻨﺴﺒﺔ‬ ‫اﻟﺠﺮﻋﺔ‬250‫ﻣﻠﺠﻢ‬/‫ﻛﺠﻢ‬=‫اﻟﻮزن‬/2‫اﻟﻄﻔﻞ‬ ‫وزن‬ ‫ﻟﻮ‬10‫ھﻰ‬ ‫اﻟﻤﺴﺘﺨﺪﻣﺔ‬ ‫اﻟﯿﻮﻣﯿﺔ‬ ‫اﻟﺠﺮﻋﺔ‬ ‫اذا‬ ‫ﻛﺠﻢ‬10/2=5‫ﻣﻞ‬
ORAL DRUGS
‫اﺳﺘﺨﺪام‬ ‫ﯾﻤﻜﻦ‬)125‫ﺳﻨﺔ‬ ‫ﻣﻦ‬ ‫ﻻﻗﻞ‬ ‫ﯾﻮﻣﯿﺎ‬ ‫ﻣﺮﺗﯿﻦ‬(‫و‬)125‫ﻣﻦ‬1-5‫ﺳﻨﻮات‬3‫او‬ ‫ﯾﻮﻣﯿﺎ‬ ‫ﻣﺮات‬250‫ﯾﻮﻣﯿﺎ‬ ‫ﻣﺮﺗﯿﻦ‬(‫و‬)250‫ﺛﻼت‬‫ﻣﻦ‬ ‫ﯾﻮﻣﯿﺎ‬ ‫ﻣﺮات‬5–10‫ﺳﻨﻮات‬(
20 – 40 mg/kg/day in divided doses every 8 hoursamoxicillin
25 – 50 mg/kg/day of the 4 parts amoxicillin , 1 part clavulanic acid preparations (which
corresponds to a daily dosage of the equivalent of 20-40 mg/kg of amoxycillin and 5-10
mg/kg of clavulanic acid) to be taken in divided doses every 8 hours at the start of a meal
Amoxicillin+
clavulanic acid
50 –100 mg/kg/day in doses divided every 6 hoursAmpicillin
25 – 50 mg/kg/day in 3 – 4 divided doses
Cephalexin &
Chloramphenicol
25 – 50 mg/kg/day in divided doses every 8 hoursCephradine
25 – 50 mg/kg/day in asingle dose or in divided doses every 12 hourscefadroxil
20 – 40 mg/kg/day in divided doses every 8 hoursCefaclor
20 – 40 mg/kg/day in asingle dose or in divided doses every 12 hoursCefprozil
20 – 40 mg/kg/day in divided doses every 12 hourscefuroxime
8 mg/kg/day in divided doses every 12 hoursCefpodoxim
14 mg/kg/day in asingle doseCefdinir
8 mg/kg/day in asingle dose dose or in divided doses every 12 hoursCefixime
‫اﻟﯿﻮﻣﯿﺔ‬ ‫اﻟﺠﺮﻋﺔ‬=‫اﻟﻮزن‬) *3/4(‫ﻟﺘﺮﻛﯿﺰ‬200‫ﻣﻠﺠﻢ‬/5‫ﻣﻞ‬30 – 50 mg/kg/day in 3 – 4 divided dosesErythromycin
‫اﻟﺠﺮﻋﺔ‬=‫اﻟﻮزن‬/2‫ﻟﺘﺮﻛﯿﺰ‬100‫واﻟﻮزن‬/4‫ﻟﺘﺮﻛﯿﺰ‬20010 mg/kg/day in asingle doseAzithromycin

2. ‫اﻟﺠﺮﻋﺔ‬=‫اﻟﻮزن‬) *6/10(‫ﻟﺘﺮﻛﯿﺰ‬125‫و‬)3/10(‫ﻟﺘﺮﻛﯿﺰ‬25015 mg/kg/day in divided doses every 12 hClarithromycin
0.5 – 1 ml / kg /day in divided doses every 12 hours
Sulphamethoxazole+
Trimethoprim
Parenteral
50– 100 mg/kg/day in divided doses every 8 hoursAmoxicillin
100 –150 mg/kg/day in doses divided every 6 hoursAmpicillin
150 mg/kg/day in doses divided every 6 hoursSultamicillin
3 months-12 years: --> Usually 30mg/kg every 8 h. (In more serious infections,
increase frequency to every 6 h)
0-3 months: in premature (less than 4kg) --> 30mg/kg every 12 hrs
Co-Amoxiclav
50 - 100 mg/kg/day in 4 equally divided doses.Cephradine
Children and infants
50-100 mg/kg/day in 2-4 divided doses. A maximum dose of 200 mg/kg/day in 2-4
divided doses may be given in exceptional cases.
0 - 1 week of age ► 50 mg/kg IV every 12 h
1 - 4 weeks of age ► 50 mg/kg IV every 8 h
Cefotaxime
25 -100 mg/kg every 12 hoursCefoperazone
Infants and young children may receive from 20-80 mg per kg body-mass daily;
depending on the severity of the infection, usually 12-24 hourly.
In cases of premature babies, the daily dosage should not exceed 50 mg per kg body
mass on account of the immaturity of the infant’s enzyme systems.
Ceftriaxone
50 - 100 mg/kg/day in 2 divided doses.Ceftazidime
days. For moremg/kg q12h for 10kg: 5040<Patients 2 months of age with body weight
severe infections, a dosage schedule of q8h can be used.
Experience with the use of MAXIPIME in paediatric patients <2 months of age is
limited. While this experience has been attained using the 50 mg/kg dose, modelling of
pharmacokinetic data obtained in patients >2 months of age suggests that a dosage of
30 mg/kg q12h or q8h may be considered for patients aged 1 month up to 2 months.
Cefipime
3– 5 mg/kg/day in divided doses every 8 hoursGentamicin
15 mg/kg/day divided into 2 or 3 equal doses. Treatment should preferably not continue
for longer than 7 to 10 days, and the total dosage in adults should not exceed 15g .
Amikacin
Side effects of antibiotics
Co-trimoxazole ( sutrim )®QuinolonesMacrolidesAminoglycosides
Hypersensitivity
Crystaluria&Megaloplastic anemia
Bone marrow inhibition
Displace bilirubin
Nephrotoxicity&Hepatotoxicity
Arthropathy
Photosensitivity
Headache & seizures
Nephrotoxic &Crystaluria
Ototoxicity
Jaundice
Epigastric pain
Ototoxicity
Nephrotoxicity
S. M. relaxation
Aminoglycosides + Cephalosporins & Frusemide → ↑ their Nephrotoxicity
Aminoglycosides + Loop diuretics & Aspirin → ↑ their Ototoxicity
Aminoglycosides + Penicillins → Synergism . But never mixed in same container