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Classification and Prediction
β€Ί Learning Task
– Given: Expression profiles of leukemia patients and healthy
persons.
– Compute: A model distinguishing if a person has leukemia from
expression data.
β€Ί Classification Task
– Given: Expression profile of a new patient + a learned model
– Determine: If a patient has leukemia or not.
 Often high dimension of data.
 Hard to put up simple rules.
 Amount of data.
οƒ˜ Need automated ways to deal with the data.
οƒ˜ Use computers – data processing, statistical analysis, try to learn
patterns from the data (Machine Learning)
o Binary Classification problem
o The data above the red line
belongs to class β€˜x’
o The data below the red line
belongs to class β€˜o’
 Examples: SVM, Probabilistic
Classifier
x
x
x
x
xx
x
x
x
x
o
o
o
o
o
o
o
o
o o
o
o
o
o Classification of high-dimensional
data sets
o No need for feature selection
o Quadratic programming problem
o Finds an optimal solution.
o Most successful current text
classification method
o Lots of possible linear separator
o Select one that maximizes the margin!
o Separator depends only on a small
number of training examples.
f(x) =-1
=+1
Var1
Var2
Margin
Width
Margin
Width
Var1
Var2
Margin
Width
Support Vectors
Var1
Var2
0
x
 Datasets that are linearly separable work out
great
 But what are we going to do if the dataset is just too
hard?
0
x
0
x
 How about … mapping data to a higher-dimensional
space:
0
x
β€Ί Mapping to transform training data into a higher
dimension
β€Ί With the new dimension, it searches for the linear
optimal separating hyperplane.
β€Ί With an appropriate nonlinear mapping, data from two
classes can always be separated by a hyperplane.
β€Ί SVM finds this hyperplane using support vectors.
Ξ¦: x β†’ Ο†(x)
π‘₯2
2
π‘₯1
2
√2π‘₯1 π‘₯2
π‘₯1
π‘₯2
β€Ί Impossible to perfectly separates the two classes
Space
𝑀 𝑀 β†’ π‘π‘’π‘Ÿπ‘π‘’π‘›π‘‘π‘–π‘π‘’π‘™π‘Žπ‘Ÿ π‘‘π‘œ π‘Ÿπ‘œπ‘Žπ‘‘
𝑒 𝑒 β†’ π‘’π‘›π‘˜π‘›π‘œπ‘€π‘› π‘£π‘’π‘π‘‘π‘œπ‘Ÿ
𝑀. 𝑒 β‰₯ 𝑐 𝑀. 𝑒 β†’ π‘π‘Ÿπ‘œπ‘—π‘’π‘π‘‘π‘–π‘œπ‘› π‘œπ‘“ 𝑒 π‘‘π‘œ 𝑀
𝑀. 𝑒 + 𝑏 β‰₯ 0 then +
𝑀
𝑒
𝑀. π‘₯+ + 𝑏 β‰₯ 1
𝑀. π‘₯βˆ’ + 𝑏 ≀ βˆ’1
𝑀. 𝑒 + 𝑏 β‰₯ 0 --- (1)
πΌπ‘›π‘‘π‘Ÿπ‘œπ‘‘π‘’π‘π‘’ 𝑦𝑖 such that,
𝑦𝑖 = +1 πΉπ‘œπ‘Ÿ + π‘ π‘Žπ‘šπ‘π‘™π‘’π‘ 
𝑦𝑖 = βˆ’1 πΉπ‘œπ‘Ÿ βˆ’ π‘ π‘Žπ‘šπ‘π‘™π‘’π‘ 
𝑀
𝑒
𝑦𝑖 ( 𝑀. π‘₯𝑖 + 𝑏) β‰₯ 1
𝑦𝑖( 𝑀. π‘₯𝑖 + 𝑏) ≀ (βˆ’1) 𝑦𝑖
β‡’ 𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 β‰₯ 1
𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 βˆ’ 1 β‰₯ 0
π‘π‘œπ‘€,
𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 βˆ’ 1 = 0, for Gutter --- (2)
π‘₯+π‘₯βˆ’
π‘₯+ βˆ’ π‘₯βˆ’
π‘€π‘–π‘‘π‘‘β„Ž = π‘₯+ βˆ’ π‘₯βˆ’ βˆ—
𝑀
𝑀
=
2
𝑀
𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 βˆ’ 1 = 0
𝑀. π‘₯+ = 1 βˆ’ 𝑏
𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 βˆ’ 1 = 0
𝑀. π‘₯βˆ’ = 1 + 𝑏
𝑀𝐴𝑋
2
𝑀
= 𝑀𝐴𝑋
1
𝑀
= 𝑀𝐼𝑁 𝑀 = 𝑀𝐼𝑁
1
2
𝑀 2

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Support Vector Machine Classifiers

  • 2. β€Ί Learning Task – Given: Expression profiles of leukemia patients and healthy persons. – Compute: A model distinguishing if a person has leukemia from expression data. β€Ί Classification Task – Given: Expression profile of a new patient + a learned model – Determine: If a patient has leukemia or not.
  • 3.  Often high dimension of data.  Hard to put up simple rules.  Amount of data. οƒ˜ Need automated ways to deal with the data. οƒ˜ Use computers – data processing, statistical analysis, try to learn patterns from the data (Machine Learning)
  • 4. o Binary Classification problem o The data above the red line belongs to class β€˜x’ o The data below the red line belongs to class β€˜o’  Examples: SVM, Probabilistic Classifier x x x x xx x x x x o o o o o o o o o o o o o
  • 5. o Classification of high-dimensional data sets o No need for feature selection o Quadratic programming problem o Finds an optimal solution. o Most successful current text classification method
  • 6. o Lots of possible linear separator o Select one that maximizes the margin! o Separator depends only on a small number of training examples. f(x) =-1 =+1
  • 10. 0 x  Datasets that are linearly separable work out great  But what are we going to do if the dataset is just too hard? 0 x
  • 11. 0 x  How about … mapping data to a higher-dimensional space: 0 x
  • 12. β€Ί Mapping to transform training data into a higher dimension β€Ί With the new dimension, it searches for the linear optimal separating hyperplane. β€Ί With an appropriate nonlinear mapping, data from two classes can always be separated by a hyperplane. β€Ί SVM finds this hyperplane using support vectors.
  • 13. Ξ¦: x β†’ Ο†(x)
  • 15. β€Ί Impossible to perfectly separates the two classes
  • 16. Space 𝑀 𝑀 β†’ π‘π‘’π‘Ÿπ‘π‘’π‘›π‘‘π‘–π‘π‘’π‘™π‘Žπ‘Ÿ π‘‘π‘œ π‘Ÿπ‘œπ‘Žπ‘‘ 𝑒 𝑒 β†’ π‘’π‘›π‘˜π‘›π‘œπ‘€π‘› π‘£π‘’π‘π‘‘π‘œπ‘Ÿ 𝑀. 𝑒 β‰₯ 𝑐 𝑀. 𝑒 β†’ π‘π‘Ÿπ‘œπ‘—π‘’π‘π‘‘π‘–π‘œπ‘› π‘œπ‘“ 𝑒 π‘‘π‘œ 𝑀 𝑀. 𝑒 + 𝑏 β‰₯ 0 then +
  • 17. 𝑀 𝑒 𝑀. π‘₯+ + 𝑏 β‰₯ 1 𝑀. π‘₯βˆ’ + 𝑏 ≀ βˆ’1 𝑀. 𝑒 + 𝑏 β‰₯ 0 --- (1) πΌπ‘›π‘‘π‘Ÿπ‘œπ‘‘π‘’π‘π‘’ 𝑦𝑖 such that, 𝑦𝑖 = +1 πΉπ‘œπ‘Ÿ + π‘ π‘Žπ‘šπ‘π‘™π‘’π‘  𝑦𝑖 = βˆ’1 πΉπ‘œπ‘Ÿ βˆ’ π‘ π‘Žπ‘šπ‘π‘™π‘’π‘ 
  • 18. 𝑀 𝑒 𝑦𝑖 ( 𝑀. π‘₯𝑖 + 𝑏) β‰₯ 1 𝑦𝑖( 𝑀. π‘₯𝑖 + 𝑏) ≀ (βˆ’1) 𝑦𝑖 β‡’ 𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 β‰₯ 1 𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 βˆ’ 1 β‰₯ 0 π‘π‘œπ‘€, 𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 βˆ’ 1 = 0, for Gutter --- (2)
  • 19. π‘₯+π‘₯βˆ’ π‘₯+ βˆ’ π‘₯βˆ’ π‘€π‘–π‘‘π‘‘β„Ž = π‘₯+ βˆ’ π‘₯βˆ’ βˆ— 𝑀 𝑀 = 2 𝑀 𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 βˆ’ 1 = 0 𝑀. π‘₯+ = 1 βˆ’ 𝑏 𝑦𝑖 𝑀. π‘₯𝑖 + 𝑏 βˆ’ 1 = 0 𝑀. π‘₯βˆ’ = 1 + 𝑏 𝑀𝐴𝑋 2 𝑀 = 𝑀𝐴𝑋 1 𝑀 = 𝑀𝐼𝑁 𝑀 = 𝑀𝐼𝑁 1 2 𝑀 2