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13 Describe the 3 stages of cell signalling using the exam.pdf

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13. Describe the 3 stages of cell signalling (using the examples of a) a growth factor, b) epinephrine and c) testosterone) a. Reception - role of receptors, when are the receptors cell membrane receptors and when are they intracellular? What is a ligand-gated ion channel? What is a ligand? What is a signalling molecule (or just signal molecule) (don't need to know G protein- coupled receptor) b. Transduction - what are relay molecules? What is a phosphorylation cascade? Relate to the "roleplaying" activity we did in class where each volunteer changed their "shape" as a result of "binding" to another (don't need to know the specific molecules involved in transduction, the 2nd messengers such as protein kinases and cAMP) c. Response - describe different types of cellular response, eg what is the role of transcription factors.

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13. Describe the 3 stages of cell signalling (using the examples of a) a growth factor, b) epinephrine and c) testosterone) a. Reception - role of receptors, when are the receptors cell membrane receptors and when are they intracellular? What is a ligand-gated ion channel? What is a ligand? What is a signalling molecule (or just signal molecule) (don't need to know G protein- coupled receptor) b. Transduction - what are relay molecules? What is a phosphorylation cascade? Relate to the "roleplaying" activity we did in class where each volunteer changed their "shape" as a result of "binding" to another (don't need to know the specific molecules involved in transduction, the 2nd messengers such as protein kinases and cAMP) c. Response - describe different types of cellular response, eg what is the role of transcription factors

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