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Artifact Two –
Skeletal Physiology
FOUR TYPES OF BONES:
Short bones: carpals and tarsals (bones in your fingers and toes)

Flat bones: Calvarium (skull bone), sternum, or scapula
Long bones: femur, tibia and fibula (all leg bones) or humerus, radius and ulna
(arm bones)
Irregular bones: bones that can't fit into the above categories: vertebrae
(spine), hyoid, maxilla and mandible (jaw), and the bones of your sinuses:



        Six Major structures of a
           typical long bone:
ethmoid, zygomatic, and sphenoid (1)
Diaphysis: main or midsection/ shaft of a long bone. Made up of cortical bone
and usually contains bone marrow and adipose tissue.
Epiphyses: End of a long bone that is originally separated from the main bone.
(1)
Articular Cartilage: smooth, white tissue that covers the ends of bones in joints.
(1)
Periosteum: a specialized connective tissue covering all bones and having
bone-forming potentialities. (1)
Medullary (marrow) Cavity: space in a bone where a soft, flexible substance
called marrow is stored. (1)
Major constituents of bone as a tissue:
Endosteum: thin layer of cells lining the medullary cavity of a bone. (1)
Composition of bone Matrix: The release of these growth factors from the bone
matrix could cause the proliferation of osteoblast precursors. (1)

Inorganic matrix: structural strength (1)

Measuring bone mineral density: Proxy measurement for bone strength. (1)
Organic Matrix: elements of a bone are primarily collagen. It allows bones to
flex. (1)




                 TYPES OF BONE
                     CELLS:
Osteoblasts- are small cells that synthesize and secrete a specialized organic
matrix, called Osteoid, that is an important part of the ground substance of
bone.
Osteoclasts- are giant Multinucleate cells that are responsible for the active
erosion of bone minerals.
Osteocytes- Are mature, nondividing osteoblasts that have become surrounded
by matrix and now lie within lacunae. (1)




                             © (6)                             © (7)
HaversianSystem
The osteon or Haversian system is the fundamental functional unit of compact
bone. Osteons are roughly cylindrical structures that are typically several
millimeters long and around 0.2mm in diameter. They are present in many
bones of most mammals and some bird, reptile and amphibian species. (1)




                                                                   © (5)


Lacunae Containing Osteocytes- (Latin for the Lakes) Small Spaces containing
Tissue fluid in which bone cells lie imprisoned between the hard layers of the
lamellae.

Lamellae-Concentric, Cylinder-shaped layers of calcified matrix
Canaliculi- Ultrasmall canals radiating in all directions from the Lacunae and
Connecting them to each other and into a larger canal, The Haversian canal.

Haversian Canal- Extends lengthwise through the center of each Haversian
system; contains blood vessels, Lymphatic Vessels, and nerves from the
HaversianCanal; nutrients and oxygen move through canaliculi to the Lacunae
and their bone cells--- a short distance of about 0.1 mm or less.
Volkmann’s canal and communicating canals that contain nerves and vessels
that carry blood and lymph from the exterior surface of the bone to the
Osteons.

Osteons- Compact bones that contain many cylinder-shaped structural units.




 Homeostatic Functions of
         Bones
  1.   Support – bones act as the framework for our body, creating the shape of our
       skeleton
  2.   Protection –our bones help protect our vital organs, like the rib cage protects
       our lungs and heart
  3.   Movement – Our muscles are attached to our bones which allow us to move
       at the joints
  4.   Mineral Storage – Bones store many minerals, such as calcium and
       phosphorus. Homeostasis blood calcium concentration is vital to living, it has
       to be equal levels in the bone and the blood (1.)
  5.   Hematopoiesis (blood cell formation)– a vital process carried out by red
       bone marrow(1.)
Ossification
   Intramembranous ossification takes place in a connective tissue membrane. It
usually involves the flat bones while endochondral ossification usually deals with long
bones.

       Intramembranous ossification deals with the fetus. Ground substance and the
collagenous fiber make the organic bone matrix. Calcification of the matrix forms
and continues until the trabeculae appear and form spongy bone. (1)

       Endochondral ossification is from cartilage models with bone formation
spreading from the center to the ends. The bone continues to grow through primary
ossification center and secondary ossification center. An epiphyseal plate remains




               Repair of Bone
                 Fractures
between the epiphysis and diaphysis. (1)
A bone fracture tears and destroys blood vessels that carry nutrients to osteocytes,
which is what initiates the repair sequence. The fracture itself is the first step in the
bone repair process. The next step is the formation of a fracture hematoma. Then it is
the formation of internal and external callus, which bind the broken fragment
together which stabilizes the wound and allows the healing process to procede. And
after that the bone remodeling is complete. (1)
CARTILAGE
 Hyaline Cartilage - provides firm support with some pliability. It covers
the ends of the long bones as articular cartilage , providing springy pads
that absorb compression at joints . Has resilient cushioning properties ;
resists compressive stress. Supports the tips of the nose , connects the ribs
to the sternum , and supports most of the respiratory system passages. The
skeletal hyaline comes during childhood as the epiphyseal plates , provide
for continued growth in length. Covers the ends of long bones in joint
cavities ; forms costal cartilages of ribs , nose , trachea , and larynx. (1)


Elastic Cartilage - Found where strength and exceptional stretch ability are
needed. Elastic cartilage forms the skeletons of the external ear and the
epiglottis. Maintain the shape of a structure while allowing great flexibility.
Similar to hyaline but more elastic fibers in matrix. (1)


Fibrocartilage- Compressible and resists tension well , found where strong
support and the ability to with strand heavy pressure are required. EX: the
spongy cartilage of the knee , Intervertebral discs Strength with the ability
to absorb compressive shock.
Less firm than the hyaline; thick collagen fibers predominate. (1)
Growth of Cartilage
Interstitial Growth: The cartilage cells within the substance of the tissue
mass divide and begin to secrete additional matrix. Internal division of
chondrocytes is possible because of the soft, pliable nature of cartilage
tissue. This type of growth is mostly seen during childhood and early
adolescence, when the majority of the cartilage is still soft and capable of
expansion from within (1)
Appositional Growth: This occurs when chondrocytes in the deep layer of
the perichondrium begin to divide and secrete additional matrix. The new
matrix is then deposited on the surface of the cartilage, causing it to
increase in size. This type of growth is unusual in early childhood but, once
it starts it continues beyond adolescence and throughout an individual’s
life. (1)




 Classification of joints
Joints are classified into 3 major categories using a structural or a functional
scheme. If a structural classification is employed, joints are named
according to the type of connective tissue that joins the bones together,
(fibrous and cartilaginous) or by the presence of a fluid-filled joint capsule.
(synovial joints) (1)
 If a functional classification scheme is used, joints are divided into three
classes according to the degree of movement they permit. (synarthroses,
amphiarthroses, and diarthroses) (Immovable, slightly movable and freely
moveable) (1)
Fibrous joints are synarthroses. The articulating surfaces of these joints fit
closely together.
The three types of fibrous joints are:
Syndesmoses- Joints on which fibrous bands connect two bones
Sutures- Found only in the skull, teeth like projections jut out from
adjacent bones and interlock with each other with only a thin layer of
fibrous tissue between them. (1)
Gomphoses: unique joints that occur between the root of a tooth and the
alveolar process of the mandible and maxilla. (1)
Cartilaginous Joints are amphiarthroses: The bones that articulate to form a
cartilaginous joint are joined together by either hyaline cartilage or
fibrocartilage. There are two types of these


Sychondroses: Joints that are characterized by the presence hyaline cartilage
between articulating bones
Symphyses: a joint in which a pad or disk of fibrocartilage connects two
bones (1)


                     Synovial joints
They are the body’s most moveable, numerous and the most anatomically
complex joints.
Seven types of structures for synovial joins
joint capsules, synovial membrane, articular cartilage, joint cavity, menisci
(articular disks), ligaments and bursea(1)
Synovial joints are divided into three main groups: Uniaxial, biaxial, and
multiaxial
Uniaxial joints: Synovial Joints that permit movement around only one
axis and in only one plane. EX: Hinge Joints and Pivot Joints


Biaxial joints: Diaphroses that permit movement around two perpendicular
axes in two perpendicular planes EX: Saddle Joints and Condyloid Joints
Multiaxial Joints: Joints that permit movement around three or more axes
and in three or more planes EX: Ball and Socket joints and Gliding joints
(1)



                  Questions
The 2 functions that have gone awry that cause the need for a bone
marrow transplant and osteoporosis are low bone mineral density due to
not enough calcification. The normal process should be the calcification of
highly specialized crystals of calcium and phosphate. A bone marrow
transplant is performed if someone has damaged bone marrow, normally
red blood marrow produces red blood cells and yellow bone marrow is
saturated in fat not involved in blood cell production but can change to red
bone marrow
if needed. (1)
A fracture in the epiphyseal plate can cause problems in kids because
their bones have not finished growing, the epiphyseal plate is there as a
barrier between the shaft and end of the bone and if it gets fractured it can
cause problems in the ossification process.
      As you get older your bones start to weaken and you start to have
bone loss. With this bone loss comes changes in your skeletal frame, you
get shorter and can have a humped back. You also have remodeling of in
compact bone which involves new haverian systems. (1)

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Artifact two

  • 2. FOUR TYPES OF BONES: Short bones: carpals and tarsals (bones in your fingers and toes) Flat bones: Calvarium (skull bone), sternum, or scapula Long bones: femur, tibia and fibula (all leg bones) or humerus, radius and ulna (arm bones) Irregular bones: bones that can't fit into the above categories: vertebrae (spine), hyoid, maxilla and mandible (jaw), and the bones of your sinuses: Six Major structures of a typical long bone: ethmoid, zygomatic, and sphenoid (1) Diaphysis: main or midsection/ shaft of a long bone. Made up of cortical bone and usually contains bone marrow and adipose tissue. Epiphyses: End of a long bone that is originally separated from the main bone. (1) Articular Cartilage: smooth, white tissue that covers the ends of bones in joints. (1) Periosteum: a specialized connective tissue covering all bones and having bone-forming potentialities. (1) Medullary (marrow) Cavity: space in a bone where a soft, flexible substance called marrow is stored. (1)
  • 3. Major constituents of bone as a tissue: Endosteum: thin layer of cells lining the medullary cavity of a bone. (1) Composition of bone Matrix: The release of these growth factors from the bone matrix could cause the proliferation of osteoblast precursors. (1) Inorganic matrix: structural strength (1) Measuring bone mineral density: Proxy measurement for bone strength. (1) Organic Matrix: elements of a bone are primarily collagen. It allows bones to flex. (1) TYPES OF BONE CELLS: Osteoblasts- are small cells that synthesize and secrete a specialized organic matrix, called Osteoid, that is an important part of the ground substance of bone. Osteoclasts- are giant Multinucleate cells that are responsible for the active erosion of bone minerals. Osteocytes- Are mature, nondividing osteoblasts that have become surrounded by matrix and now lie within lacunae. (1) © (6) © (7)
  • 4. HaversianSystem The osteon or Haversian system is the fundamental functional unit of compact bone. Osteons are roughly cylindrical structures that are typically several millimeters long and around 0.2mm in diameter. They are present in many bones of most mammals and some bird, reptile and amphibian species. (1) © (5) Lacunae Containing Osteocytes- (Latin for the Lakes) Small Spaces containing Tissue fluid in which bone cells lie imprisoned between the hard layers of the lamellae. Lamellae-Concentric, Cylinder-shaped layers of calcified matrix Canaliculi- Ultrasmall canals radiating in all directions from the Lacunae and Connecting them to each other and into a larger canal, The Haversian canal. Haversian Canal- Extends lengthwise through the center of each Haversian system; contains blood vessels, Lymphatic Vessels, and nerves from the
  • 5. HaversianCanal; nutrients and oxygen move through canaliculi to the Lacunae and their bone cells--- a short distance of about 0.1 mm or less. Volkmann’s canal and communicating canals that contain nerves and vessels that carry blood and lymph from the exterior surface of the bone to the Osteons. Osteons- Compact bones that contain many cylinder-shaped structural units. Homeostatic Functions of Bones 1. Support – bones act as the framework for our body, creating the shape of our skeleton 2. Protection –our bones help protect our vital organs, like the rib cage protects our lungs and heart 3. Movement – Our muscles are attached to our bones which allow us to move at the joints 4. Mineral Storage – Bones store many minerals, such as calcium and phosphorus. Homeostasis blood calcium concentration is vital to living, it has to be equal levels in the bone and the blood (1.) 5. Hematopoiesis (blood cell formation)– a vital process carried out by red bone marrow(1.)
  • 6. Ossification Intramembranous ossification takes place in a connective tissue membrane. It usually involves the flat bones while endochondral ossification usually deals with long bones. Intramembranous ossification deals with the fetus. Ground substance and the collagenous fiber make the organic bone matrix. Calcification of the matrix forms and continues until the trabeculae appear and form spongy bone. (1) Endochondral ossification is from cartilage models with bone formation spreading from the center to the ends. The bone continues to grow through primary ossification center and secondary ossification center. An epiphyseal plate remains Repair of Bone Fractures between the epiphysis and diaphysis. (1) A bone fracture tears and destroys blood vessels that carry nutrients to osteocytes, which is what initiates the repair sequence. The fracture itself is the first step in the bone repair process. The next step is the formation of a fracture hematoma. Then it is the formation of internal and external callus, which bind the broken fragment together which stabilizes the wound and allows the healing process to procede. And after that the bone remodeling is complete. (1)
  • 7. CARTILAGE Hyaline Cartilage - provides firm support with some pliability. It covers the ends of the long bones as articular cartilage , providing springy pads that absorb compression at joints . Has resilient cushioning properties ; resists compressive stress. Supports the tips of the nose , connects the ribs to the sternum , and supports most of the respiratory system passages. The skeletal hyaline comes during childhood as the epiphyseal plates , provide for continued growth in length. Covers the ends of long bones in joint cavities ; forms costal cartilages of ribs , nose , trachea , and larynx. (1) Elastic Cartilage - Found where strength and exceptional stretch ability are needed. Elastic cartilage forms the skeletons of the external ear and the epiglottis. Maintain the shape of a structure while allowing great flexibility. Similar to hyaline but more elastic fibers in matrix. (1) Fibrocartilage- Compressible and resists tension well , found where strong support and the ability to with strand heavy pressure are required. EX: the spongy cartilage of the knee , Intervertebral discs Strength with the ability to absorb compressive shock. Less firm than the hyaline; thick collagen fibers predominate. (1)
  • 8. Growth of Cartilage Interstitial Growth: The cartilage cells within the substance of the tissue mass divide and begin to secrete additional matrix. Internal division of chondrocytes is possible because of the soft, pliable nature of cartilage tissue. This type of growth is mostly seen during childhood and early adolescence, when the majority of the cartilage is still soft and capable of expansion from within (1) Appositional Growth: This occurs when chondrocytes in the deep layer of the perichondrium begin to divide and secrete additional matrix. The new matrix is then deposited on the surface of the cartilage, causing it to increase in size. This type of growth is unusual in early childhood but, once it starts it continues beyond adolescence and throughout an individual’s life. (1) Classification of joints Joints are classified into 3 major categories using a structural or a functional scheme. If a structural classification is employed, joints are named according to the type of connective tissue that joins the bones together, (fibrous and cartilaginous) or by the presence of a fluid-filled joint capsule. (synovial joints) (1) If a functional classification scheme is used, joints are divided into three classes according to the degree of movement they permit. (synarthroses, amphiarthroses, and diarthroses) (Immovable, slightly movable and freely moveable) (1)
  • 9. Fibrous joints are synarthroses. The articulating surfaces of these joints fit closely together. The three types of fibrous joints are: Syndesmoses- Joints on which fibrous bands connect two bones Sutures- Found only in the skull, teeth like projections jut out from adjacent bones and interlock with each other with only a thin layer of fibrous tissue between them. (1) Gomphoses: unique joints that occur between the root of a tooth and the alveolar process of the mandible and maxilla. (1) Cartilaginous Joints are amphiarthroses: The bones that articulate to form a cartilaginous joint are joined together by either hyaline cartilage or fibrocartilage. There are two types of these Sychondroses: Joints that are characterized by the presence hyaline cartilage between articulating bones Symphyses: a joint in which a pad or disk of fibrocartilage connects two bones (1) Synovial joints They are the body’s most moveable, numerous and the most anatomically complex joints. Seven types of structures for synovial joins
  • 10. joint capsules, synovial membrane, articular cartilage, joint cavity, menisci (articular disks), ligaments and bursea(1) Synovial joints are divided into three main groups: Uniaxial, biaxial, and multiaxial Uniaxial joints: Synovial Joints that permit movement around only one axis and in only one plane. EX: Hinge Joints and Pivot Joints Biaxial joints: Diaphroses that permit movement around two perpendicular axes in two perpendicular planes EX: Saddle Joints and Condyloid Joints Multiaxial Joints: Joints that permit movement around three or more axes and in three or more planes EX: Ball and Socket joints and Gliding joints (1) Questions The 2 functions that have gone awry that cause the need for a bone marrow transplant and osteoporosis are low bone mineral density due to not enough calcification. The normal process should be the calcification of highly specialized crystals of calcium and phosphate. A bone marrow transplant is performed if someone has damaged bone marrow, normally red blood marrow produces red blood cells and yellow bone marrow is saturated in fat not involved in blood cell production but can change to red bone marrow if needed. (1)
  • 11. A fracture in the epiphyseal plate can cause problems in kids because their bones have not finished growing, the epiphyseal plate is there as a barrier between the shaft and end of the bone and if it gets fractured it can cause problems in the ossification process. As you get older your bones start to weaken and you start to have bone loss. With this bone loss comes changes in your skeletal frame, you get shorter and can have a humped back. You also have remodeling of in compact bone which involves new haverian systems. (1)