Hyponatremia and it's types,
Clinical features
Presentation features
sodium correction
Acute and chronic manifestation
NaCl administration
Use of vaptans and dosage
Osmotic demyelination syndrome
SIADH management
3. INTRODUCTION
• Disorders of serum sodium concentration are
caused by abnormalities of water homeostasis.
• Water intake and circulating AVP- defense
mechanisms to maintain serum osmolality.
• Hyponatremia- plasma Na+ <135 mEq/L.
• Occurs due to
– Increase in circulating AVP +/_
– Increased renal sensitivity to AVP +
– Intake of free water (except low solute intake)
5. HYPOVOLEMIC HYPONATREMIA
THIAZIDES: polydipsia,
diuretic induced volume
depletion
LOOP: blocks reabsorption of
sodium by TALH, decreased
urine concentration
Increased excretion of
osmotically active
sustances(glycosuria, ketonuria,
bicarbonaturia)
CEREBRAL SALT
WASTING SYNDROME
Inappropriate
natriuresis in
association with
intracranial diseases
•Loss of Na+
and Cl-
•Freewater or
hypotonic
fluid intake
7. EUVOLEMIC HYPONATREMIA
Glucocorticoid exert
negative feedback on
AVP(1o adrenal deficiency)
reducing circulating AVP
Moderate to
severe
hypothyroidism
after correction
to euthyroid
state
Decreased CO
Increased
Vasopressin
Decrese in GFR
SIADH:
•Persistent free water intake at
serum osmolalities lower than the
threshold for thirst.
•Unregulated and erratic AVP
secretion with a normal or lower
or unrelated osmolility.
•Usually associated with
subclinically volume expanded
due to AVP induced water and
Na+ _ Cl- retention.
•Causes:
•Pulmonary(TB, pneumonia,
asthma)
•CNS(meningitis, Encephalitis,
abscess, malignancy,GBS, MS)
•Malignancy(SCC lung, GIT
Carcinoma, thymomas,
lymphomas)
•Drugs(SSRI,TCA, NSAIDS, CBZ,
etc.,)
•Hereditary, idiopathic
8. BEER PROTOMANIA
• Occurs in patients with very low intake of
dietary solutes.
• Causes:
– Beer protomania
– Nutrient restricted diets(extreme vegetarians)
• Hyponatremia is associated with very low
urine osmolality(<100-200 mOsm/kg) and
urine sodium <10-20 mEq/L.
• Recovery with resumption to normal diet and
saline rehydration.
9. PSEUDOHYPONATREMIA
• Low sodium with normal/high osmolality
• Causes:
– Translocational hyponatremia due to presence of
effective solutes in plasma eg., glucose, maltose,
glycine, mannitol
– Methodology used for sodium measurement eg.,
Flame spectrophotometry-presence of lipids and
proteins can give a false decrease in sodium
values. Avoided by using other methods such as
ion sensitive electrodes.
10. CLINICAL FEATURES
• ACUTE HYPONATREMIA:
Causes: Presentation:
• Acute hyponatremic
encephalopathy
• Acute cerebral edema
– Nausea, vomiting
– Headache
– Seizures
– Brainstem herniation
leading to coma
– Normocapneic or
hypercapneic respiratory
failure
– Noncardiogenic, neurogenic
pulmonary edema
11. • CHRONIC HYPONATREMIA:
– Asymptomatic with subtle gait and cognitive
disturbances
– Nausea,vomiting
– Confusion
– Seizures
– Recurrent falls
– Risk of bony fractures due to hyponatremia
associated reduction in bone density.
13. EVALUATION AND TREATMENT
• STEP 1: ASSESSMENT OF OSMOLALITY:
– True hyponatremia = low osmolality
– Pseudohyponatremia = high / normal osmolality
• STEP 2 : Assessment of volume status:
– Hypo/Hyper/Euvolemic
SERUM OSMOLALITY = (2 X Na+) + (GLUCOSE/18) +(BUN/2.8)
Normal = 275 -295 m0sm/kg
14. CHOICE OF TREATMENT
• Hypovolemic hyponatremia: IV saline
Target Na+ correction= 8 – 10mEq / L / day
Eg. 60kg patient with Sr. Na+ 100 mEq/L
1L of NS=154-100/(60%of 60)+1=54/37=1-2mEq/L
Target Na+ correction=8 mEq / L / day = 4L NS /day
1L of RL=130-100/(60%of 60)+1=30/37=0.8mEq/L
Target Na+ correction=8 mEq / L / day = ~8L NS /day
1 litre of a fluid = (Infusate Na+ - Serum Na+) / Total body water + 1
15. • Acute euvolemic hyponatremia: 3% NaCl
100ml of 3% NaCl = 51.3 mEq of Na+
Eg. 60kg euvolemic patient with Sr. Na+ 95 mEq/L
I method:
1L of 3% NaCl =513-95/(60%of 60)+1
=418/37 = 12mEq/L
100ml 3% NaCl over 10 min repeated thrice rise
Na+ by 3-4 mEq/L
16. II method: 24 hrs correction
1L of 3% NaCl = 11-12mEq/L
Target Na+ correction= 8 – 10mEq / L / day
# for increasing Sr. Na by 8 mEq=1/8
=0.7L or 700ml over 24hrs
=1 bottle 3%NaCl every 3.25hrs
17. • Chronic euvolemic hyponatremia (post 48hrs)
– If symptomatic similar management as acute one.
– If stable or mild neurological symptoms water restriction
based on
>1 = <500ml/day
~1 = 500-700 ml/day
>1 = <1L/day
o If corrected with 3%NaCl, central pontine myelinosis/osmotic
demyelination syndrome occurs due further shrinkage of brain.
Associated hypokalemia correction tends to overcorrect
sodium.
increase in dietary solute intake: oral salt tablets,
palatable urea
Urine-to-plasma electrolyte ratio={Urine [Na+]+[K+]} / Plasma [Na+]
18. Pharmacological treatment to increase sodium:
SIADH:
Oral FUROSEMIDE 20mg BD + Oral salt tablets
If above fails, DEMECLOCYCLINE
Palatable urea
Inhibits renal
countercurrent
mechanism &
Blunts urinary
concentrating
ability
Inhibits diuretic
associated
natriuresis
Potent inhibitor of
principal cells
Increased
nephrotoxicity in
cirrhosis patients
Increase free water
excretion and decrease
plasma sodium
19. VAPTANS:
Mechanism: increases Na+ by aquaretic (free water
clearance) effects.
Uses:
SIADH
Hypervolemic hyponatremia due to Cirrhosis and Heart
Failure.
Drugs:
Oral V2 antagonist TOLVAPTAN:chronic use causes
abnormal LFT
IV mixed V1A/V2 antagonist CONIVAPTAN: risk of
hypotension.
Prerequisite: Liberalisation of fluids(>2l/day)
Duration: <1-2 months
20. OSMOTIC DEMYELINATION
SYNDROME
• Degenerative loss of oligodendrocytes of pons.
• CAUSES:
– Reaccumulation of organic osmolytes by brain cells is
attenuated and delayed as osmolality increases after
hyponatremia is corrected.
– Rapid correction of hyponatremia {>8-10 mEq/L in 24
hrs or 18 mEq/L in 48 hrs} disrupts BBB.
– Slow correction ODS if additional risk factors present
(alcoholism, hypokalemia, malnutrition, liver
transplantation)
21. CLINICAL FEATURES:
• Central pontine
myelinosis one or more
days after
overcorrection
• Para/quadriparesis
• Dysphagia
• Dysarthria
• Diplopia
• Locked-in-
syndrome
• Loss of
consciousness
• Extra pontine
myelinosis
• Ataxia
• Mutism
• Dystonia
• Catatonia
• Parkinsonism.