Pathology

1. Male Reproductive System

3. Penile Diseases
1-Congenital malformations:
– Hypospadiasis : Ventral orifice
– Epispadiasis: dorsal orifice
– Phymosis : small prepuse orifice

5. 2- Inflammations : STDs: balanitis
3- Tumors
– Benign : Condyloma
accuminatum (HPV)
– Malignant :
• Ca insitu ( bowen disease)
• Squamous cell Ca (HPV 16, 18)
Penile Diseases

6. Testes and Epididymis
• Congenital : Cryptorchidism (clinical
importance??)
• Atrophy : causes and effects
• Inflammation : Epydidymo-orchitis
• Causes:
• Clinical features
• Testicular Torsion:
• Testicular Tumors

7. Causes Of Scrotal Swelling
• Testicular tumors
• Testicular infections ( mumps, TB,..)
• Testicular torsion
• Hernia
• Varicocele
• Hydrocele
• ………

8. • A varicocele is an enlargement of the veins in the
testicles due to an abnormal blood flow.
• a hydrocele is the presence of fluid in the scrotum,
which function is to allow testicular mobility and to
absorb the shocks. A hydrocele is commonly caused
by inflammation of the testes.

9. Testicular Tumors
WHO Classification
Single Histogenic
Tumors(40%)
Seminomas (30%)
Teratoma
Embryonal Carcinoma
Yolk Sac Tumor
Choriocarcinoma
Sex cord Tumors
Combined
Tumors(60%)
MIXED

10. Seminoma
• The most common (30%)
• Age 20 – 30 yrs
• Clinically : painless lobulated swelling
• Histologically :
– Large clear cells with central Nuclei
– Fibrous stroma
– lymphocytic infiltrate
• Diagnosis

11. Seminoma

12. Disorders OF Prostate
• Prostatitis
– Acute bacrerial
– Chronic bacterial
– Chronic abacterial
• Benign Nodular Hyperplasia
• Ca Prostate

13. Benign Prostatic hyperplasia
• Very common in old males
• Pathogenesis: ↑ DHT and Estrogen
• Clinically
– Urine retention
– Frequency, nocturea, UTI
– Bladder hypertrophy
• Pathology: middle lobe nodularity,↑↑
glands + fibromuscular stroma

14. BPH Ca Prostate

15. Carcinoma of the Prostate
• Most common male cancer
• 2nd causes of male cancer death
• 65- 75 yrs
Pathogenesis
• Hormonal
• /Environmental/
• Genetic bases

16. Clinical /f
• local
• General
Pathology
Macro: ... Site . Shape , color ,..
Micro: Adenocarcinoma

17. URETHRA
PERIPHERAL
ZONE
NORMAL
BNH CARCINOMA

19. Diagnosis
• Clinical
• Radioolgical
• Lab
- routine
- FNA , true-cut, biopsy
- tumor markers

20. Prostatic biopsy