A presentation on Arsenic Poisoning, from a brief history, compounds, uses, circumstances of poisoning, types with clinical symptoms, diagnosis, treatment and postmortem findings. Subject from Forensic Medicine and Toxicology.
#arsenicpoisoning #arsenic
2. HISTORY OF ARSENIC
Word meaning Arsenic is ‘STRONG POISON’
Used in ancient times as poison for Political Assasinations.
There are romours that Nepoleon was killed by Arsenic Poisoning.
Some hairs from scalp were analysed revealing fluctuating levels of
arsenic.
3. INTRODUCTION
Categorized under irritant poisoning
Sub- Metallic poisoning.
Metallic arsenic is not poisonous.
When volatilised by heat unites with O2 and forms poisonous
vapour of As2O3.
Common environmental toxicant, found in soil, water and air.
Abundance : Earth’s crust- 20th, Sea water-14th, Human body-12th.
4. COMPOUNDS
1. Arsenious oxide or Arsenic trioxide (Sankhya / Somalkhar/ Gouripashana):
Commonest form used, White Arsenic, No taste or Smell, Low Solubility.
2. Copper Compounds: Colouring Agent
Copper arsenite (Scheele’s Green) & Copper acetoarsenite (Paris Green).
3. Arsenic acid.
4. Sodium and Potassium Arsenate.
5. Arsenic Sulphide (Manashila As2S2 & Haratala As2S3): Colouring Agent.
6. Organic Compounds.
7. Arsine Gas (colourless gas with garlic like non-irritating odour)
8. Environmental sources like contaminated drinking water (as in Bangladesh),
mineral species, marine animals.
5. USES
Rat Killer Calico printing Fruit spray Sheep dips
Weed killer Taxidermy Fly papers Preserving timber
6. ACTIONS
Interferes with cellular respiration, Glycolysis (by combining with
Sulphydryl groups of mitochondrial enzymes)
Pyruvate to acetyl CoA reduced, decreased ATP production
Particularly targets vascular endothelium leading to increased
permeability, tissue oedema and haemorrhage especially in intestinal
canal.
Local action – Irritation to mucous membrane
Remote action – Depression of Nervous system.
7. ABSORPTION
Orally (pentavalent arsenic)
Dermally (Arsenite)
Inhalation (Arsine)
Parenterally
DISTRIBUTION
Once absorbed Arsenic rapidly combines with Globin of Hb and then localize in
blood, within 24hours it redistribute to liver, kidney, spleen, lungs and GI tract, lesser
accumulation in muscle and nervous tissue (including brain)
Replaces phosphorous in bone and remains for years, found in keratin tissues of
hair, nail and skin for years
ELIMINATION
Excreted mainly by kidney in the form of methylated arsenic
Also by feaces, bile, sweat and other secretions
8. CIRCUMSTANCES
Arsenic is a Popular Homicidal Poison
Cheap
Easy availability
Colourless
Odourless
Tasteless
Small quantity can be fatal
Can be easily administered with food or drinks
Gradual onset of symptoms
Symptoms of Gastro-enteric type stimulate those of Cholera
9. Disadvantages of As
Delays Putrefaction.
Can be detected in completely decomposed bodies.
Can be found in Hair, bones and nails for several years.
Can be detected in charred bones or ashes.
11. FULMINENT TYPE
Massive dose (3–5g) causes rapid or delayed death
Rapid death: when rapidly absorbed causes death in 1-3 hours, due to shock
and peripheral vascular failure.
Delayed death: due to Hepato-renal failure, death can be prolonged to few
days.
Capillaries are markedly dilated with a marked fall of blood pressure.
Cyanosis, cold clammy skin.
Gastric signs are usually absent.
12. GASTROENTERIC TYPE
Common form of acute poisoning, resembles bacterial food poisoning.
Symptoms usually appear half to one hour after ingestion but may be delayed
many hours especially when taken with food.
Symptoms:
1. GIT : Burning and colicky pain in oesophagus, stomach and bowel.
Intense thirst, nausea and severe projectile vomiting.
Constriction in throat & difficulty in swallowing.
Purging accompanied with tenesmus, pain and irritation in anus.
Stools are expelled involuntarily, dark coloured, stinking and bloody
later resembles rice water stools of cholera.
Garlicky odour of breath and faeces maybe noted
13. DIFFERENCES:
TRAIT ARSENIC POISON CHOLERA
1. PAIN IN THROAT BEFORE VOMITING AFTER VOMITING
2. PURGING FOLLOWS VOMITING PRECEDS VOMITING
3. STOOLS BLOODY, DARK
COLOURED, LATER RICE
WATERY
RICE WATERY STOOLS,
NOT BLOODY,
INVOLUNTARY
4. TENESMUS PRESENT ABSENT
5. VOMITED MATTER CONTAINS MUCOUS,
BILE AND BLOOD
WATERY AND WITHOUT
MUCUS, BLOOD, BILE
14. 2. Hepatic : Fatty infiltration, Hepatomegaly.
3. Renal: Oliguria, uraemia, albuminuria, hematuria, pain in micturition.
4. C.V.S: acute circulatory collapse with vasodilation, increased vascular
permeability, ventricular fibrillation, ventricular tachycardia.
Death is usually due to circulatory failure.
15. NARCOTIC FORM
Can be due to improper medicinal use or use of As as an aphrodisiac, etc.
It produces mainly CNS symptoms
Giddiness, formication and tenderness of the muscles
Delirium, coma, death
Rarely paralysis
Loss of memory and speech
Convulsions
Stocking glove pattern
16. ARSINE GAS
Arsine gas acts as poison to haemoglobin and cause haemolysis.
It mostly produces haemoglobinuria, anaemia, and renal failure.
Death is almost instantaneous.
17. FATAL DOSE
0.1 – 0.3 g As2O3
FATAL PERIOD
1 – 2 days (sometimes few hours is enough)
18. CHRONIC POISONING
CAUSE
SYMPTOMS
Accidental ingestion of repeated small doses (workers).
Repeated intake of food or drink in which there are traces of drug.
Polyneuritis, Anaesthesias, Paraesthesia, Encephalopathy.
Photophobia, Congestion and watering of eyes.
Hepatomegaly, jaundice, cirrhosis.
Pigmentation : Rain drop type of pigmentation, Hyperkaratosis, Epithelial
hyperplasia, Leucomelanosis, Arsenicosis
Aldrich-Mees Lines: Development of white transverse lines in finger nails.
Chronic nephritis, bone marrow suppression, thrombocytopenia.
23. DIAGNOSIS
Acute poisoning: findings in blood Sample
Chronic poisoning: findings in hair, nail and bones
Some tests like Marsh test, Reinsch test
24. TREATMENT
Stomach wash with large amount of warm water and milk.
Freshly precipitated, hydrated, ferric oxide in small doses (converts toxic arsenic
to non toxic ferric arsenite)
B.A.L (British Anti Lewisite), chelation therapy is administered
Penicillamine can be used with B.A.L
Demulcents (ghee/barley) lessen irritation
Castor oil or MgSO4 to prevent intestinal absorption
In case of Renal failure Haemodyalisis or exchange transfusion may be given
25. POSTMORTEM FINDINGS
IN ACUTE POISONING
EXTERNAL FINDINGS
Sunken eyeballs
Cyanosed skin
Shrunken body due to dehydration
26. INTERNAL
In some cases mouth, pharynx and oesophagus maybe inflamed or ulcerated.
Lesions are found in the stomach
Swollen, oedematous and red mucosa especially in the pyloric region
Stomach mucosa resembles red velvet
Small intestinal mucosa is pale violet and inflamed
Liver, Spleen and Kidney are congested, enlarged, swollen and shows fatty
degeneration
Maybe oedema of brain with patchy necrosis or haemorrhagic encephalitis
Meninges are congested
27. POSTMORTEM FINDINGS
IN CHRONIC POISONING
Stomach may show chronic gastritis, patchy inflammatory redness in rugae
Fatty degeneration of liver maybe with severe necrosis
Tubular necrosis of kidneys
Myocardial necrosis
Pigmentation, Hyperkeratosis, Aldrich-Mees lines, ulceration of mucosa.