Successfully reported this slideshow.
Your SlideShare is downloading. ×

Behaviour of chiral molecules

Ad

Valliappan Kannappan
Valliappan Kannappan
VALLIAPPAN K
Professor of Quality Assurance (Retd.)
Department of Pharmacy
Annam...

Ad

Valliappan Kannappan
Valliappan Kannappan
Environment
Environment and Behavior
Behavior
 Behaviour of a chiral molecule d...

Ad

Valliappan Kannappan
Valliappan Kannappan
Chiral Twins
Chiral Twins
OH
O
H
CH3
HO
O
H
H3C
(R) (S)
Ibuprofen, is normally a...

Ad

Ad

Ad

Ad

Upcoming SlideShare
Importance of Chirality
Importance of Chirality
Loading in …3
×

Check these out next

1 of 7 Ad
1 of 7 Ad

Behaviour of chiral molecules

Understand the behavior of mirror-image molecules. Behavior depends on the environment (chiral/achiral) to which the molecule is exposed. When both the players (the target and the drug molecule) are chiral, there is a need for chiral perspective.

Understand the behavior of mirror-image molecules. Behavior depends on the environment (chiral/achiral) to which the molecule is exposed. When both the players (the target and the drug molecule) are chiral, there is a need for chiral perspective.

Advertisement
Advertisement

More Related Content

Advertisement

Behaviour of chiral molecules

  1. 1. Valliappan Kannappan Valliappan Kannappan VALLIAPPAN K Professor of Quality Assurance (Retd.) Department of Pharmacy Annamalai University INDIA Behaviour of chiral twins 2021 10 min.
  2. 2. Valliappan Kannappan Valliappan Kannappan Environment Environment and Behavior Behavior  Behaviour of a chiral molecule depends on the environment in which it is present or it is exposed to.  Environment can be either chiral or achiral  In an isotopic/achiral environment, enantiomers exhibit identical physicochemical properties, and B E H A V I O U R Behaviour of chiral twins 2021 exhibit identical physicochemical properties, and therefore are indistinguishable under these conditions.  Differences between chiral twins (biomolecules) are hard to detect normally, but becomes pronounced in a chiral environment”.
  3. 3. Valliappan Kannappan Valliappan Kannappan Chiral Twins Chiral Twins OH O H CH3 HO O H H3C (R) (S) Ibuprofen, is normally assayed by Alkalimetry / HPLC- ODS Column; the environment is Achiral. B E H A V I O U R Chiral center Chiral center Behaviour of chiral twins 2021 In both the cases (Alkalimetry/ HPLC – ODS column) the environment is achiral; hence one will not be able to quantify each enantiomers of the chiral drug; to measure enantiomers of a chiral twin one need to perform the assay in a chiral environment, viz. chiral analysis. Ibuprofen - Chiral twins mirror
  4. 4. Valliappan Kannappan Valliappan Kannappan Chirality and Biological Action Chirality and Biological Action Interestingly, Bio-logical systems and human body at molecular level are intensely chiral environments being composed of homochiral homochiral biopolymers) and can discriminate / differentiate left handed molecules from the right handed molecules. B E H A V I O U R Behaviour of chiral twins 2021 Limonene is a molecule with single chiral/stereogenic center; and can exist as a pair of enantiomers; R-Limonene and S-Limonene. Olfactory receptors can differentiate these chiral twins; R-form has smells Orange where as the mirror-image form (S- form) exhibits Lemon smell; the molecule and the bio-environment both are chiral.
  5. 5. Valliappan Kannappan Valliappan Kannappan O D O U R P E R C E P T limonene The nose knows! Behaviour of chiral twins 2021 (R (R) )- -(+) (+)- -Limonene Limonene (S) (S)- -( (- -) )- -Limonene Limonene T I O N limonene mirrored - configuration
  6. 6. Valliappan Kannappan Valliappan Kannappan Biological targets are chiral and so are the Behaviour of chiral twins 2021 Biological targets are chiral and so are the molecules (drugs) that interact with them Source: Christopher Welch, Chiral India, 2016. Hence there is need for chiral / mirror-image perspective
  7. 7. Valliappan Kannappan Valliappan Kannappan Thanks for you time Thanks for you time Behaviour of chiral twins 2021 valliappan valliappan Chirally Yours Chirally Yours

×