1. A BETTER WAY
TO ASSESS REDOX
STATUS IS NOW
WITHIN REACH
The RedoxSYS™ Diagnostic System
from Luoxis Diagnostics
™
brought to you by
2. ONE COMPANY DRIVEN BY
INNOVATION — OVER A DECADE OF
REDOX MEASUREMENT RESEARCH
AND DISCOVERY
Luoxis is a progressive diagnostic company that is pioneering the true
measurement of redox potential — a novel measure of oxidative stress, or redox
imbalance — which has been implicated in numerous critical injuries, illnesses,
and chronic conditions.1-4
Our proprietary RedoxSYS™ Diagnostic System is the first and only clinical
diagnostic platform that provides an accurate, easy, and complete real-time
assessment of redox status. It is an innovation to improve lives that represents
the culmination of over 10 years of research and discovery. While the company
is new, the scientific team led by Dr. David Bar-Or has been at the forefront of
technological innovation in the healthcare market for over 20 years, amassing
over 600 patents.
Luoxis Diagnostics is a majority-owned subsidiary of Ampio Pharmaceuticals. We
are currently working to make this advanced technology more widely available
to ultimately help improve the management and treatment of critical injuries and
the many diseases and conditions where redox imbalance is implicated.
3. THE VALUE OF REDOX POTENTIAL
Redox potential — which is also called oxidation-reduction potential or ORP — is an integrated measure of the balance between total oxidants and total reductants in a biological system, such as the human body.3
While redox imbalance is being widely studied in a variety of research settings, conventional methods of measuring redox balance — such as measuring individual surrogate markers — have numerous limitations and do not provide a complete picture of redox imbalance.1,2,5
The ability to easily and completely measure redox balance in real time would be incredibly helpful by allowing researchers and clinicians to assess baseline status,
as well as progression of redox imbalance-mediated diseases and conditions.
CHALLENGES WITH CONVENTIONAL MEASUREMENT METHODSUse individual surrogatemarkers (glutathione, freeradical production, proteinoxidation, etc.) Insufficient diagnostic value aloneVariable and unreliableMiss the complete pictureTime consumingImpractical for clinical settings
4. THE REDOX REACTION
Oxidation-reduction — which is also known as a redox reaction — is a process that involves transferring electrons from a reductant to an oxidant utilizing a specific equation (see fig. 1).
At equilibrium, the redox potential (E ), or oxidation-reduction potential (ORP), is calculated utilizing the Nernst equation (see fig. 2) where:2
•
R (gas constant), T (temperature in degrees Kelvin), and F (Faraday constant)
are constants
•
E0 is the standard potential of a redox system measured with respect to a hydrogen
electrode, which is arbitrarily assigned an E0 of 0 volts
•
n is the number of electrons transferred
HIGHER ORP:
Suggests a larger oxidant concentration, which is typical in diseases where
oxidative stress is implicated.
LOWER ORP:
Suggests a larger reductant concentration, which would be expected from plasma
under normal physiological conditions.
oxidant + ne- reductant
E(ORP) = E0 _ RT 1n [reductant]
[oxidant]
figure 2
figure 1
nF
5. Our novel, patented RedoxSYS Diagnostic System measures two distinct parameters to
determine redox potential, providing a complete view of oxidation across a biological system.
MEASURES STATIC ORP (sORP)
The RedoxSYS Diagnostic System provides a highly valuable overall “snapshot” of current
redox balance from a biological sample. An above-normal sORP value indicates a higher state
of redox imbalance, which appears to correlate with injury severity and mortality.
MEASURES CAPACITY ORP (cORP)
The RedoxSYS Diagnostic System indicates the amount of antioxidant reserves from a
biological sample. A below-normal value indicates a lower than normal antioxidant reserve,
which appears to correlate with injury severity and complications.
WAYS CLINICAL
WORKFLOWS MAY
BE OPTIMIZED
Enabling
objective patient
injury/illness
assessments
Allowing
for earlier
interventions
Providing
real-time
treatment
monitoring
Improving resource
allocation through
better patient
stratification
THE REDOXSYS™ DIAGNOSTIC SYSTEM
ADVANCES REDOX ASSESSMENT
Understanding a patient’s redox balance is a
highly important assessment that is currently
being studied in varying phases of preclinical,
translational, and clinical research. The
application of these results has the potential
to impact patient care at many points in the
disease management continuum.
6. FAST. EASY. CONVENIENT.
With the RedoxSYS Diagnostic System, redox potential from a biologic sample can now be accurately, easily, and completely measured in real time, providing reliable and complete results within four minutes.
FEATURE
Small, battery-powered reader
Small, easy to use
disposable strips
AC adapter
BENEFIT
• Convenient and highly portable
• Ideal for benchtop use or at a patient’s
point of care
• Simple, easy-to-use interface
• Complete test can be performed in under
four minutes
• Require limited sample manipulation
• Can be used with basic lab techniques
• Allows recharging or stationary
laboratory use
Watch a demonstration at www.luoxis.com/redoxsys.
7. HELPING ADVANCE EVERY LEVEL OF RESEARCH
The RedoxSYS Diagnostic System offers tremendous applications to benefit scientific and clinical researchers, laboratories, pharmaceutical companies, clinicians, and patients.
AT THE CELLULAR LEVEL:
The RedoxSYS Diagnostic System can provide researchers with a better understanding of redox balance in various matrices to advance current knowledge about redox imbalance. It is an indispensable tool for gaining greater clarity about the oxidative stress of cell cultures to ensure consistency and greater accuracy for validating experiments that can help generate new ideas, principles, and theories.
FOR PRECLINICAL/TRANSLATIONAL RESEARCHERS:
The RedoxSYS Diagnostic System can provide a greater understanding of disease progression in various models of acute and chronic diseases. It provides a quick and easy way to observe the treatment effect of novel compounds or interventions in translational models. It is an indispensable tool for generating clinically important applications that can then be validated in phase II trials as the next step in product development for pharmaceutical and biotechnology companies.
FOR CLINICAL RESEARCHERS:
The RedoxSYS Diagnostic System provides a complete and true assessment of a patient’s redox balance, making it an indispensable tool that can be useful to advance the understanding of patient characteristics in relation to disease severity (using redox imbalance as a marker of disease severity) and effectiveness of therapeutics that modulate redox imbalance. It can also provide a greater understanding about progression or worsening of diseases or conditions that are modulated by redox imbalance and ways to potentially predict exacerbations of a chronic condition that
is modulated by redox imbalance.
Visit www.luoxis.com/redoxsys-scientific-evidence to learn more about current
areas of ongoing research utilizing the RedoxSYS Diagnostic System.
