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Human 
Anatomy 
& Physiology 
SEVENTH EDITION 
Elaine N. Marieb 
Katja Hoehn 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
PowerPoint® Lecture Slides 
prepared by Vince Austin, 
Bluegrass Technical 
and Community College 
C H A P T E R 3Cells: The 
P A R T C 
Living Units
Golgi Apparatus 
 Stacked and flattened membranous sacs 
 Functions in modification, concentration, and 
packaging of proteins 
 Transport vessels from the ER fuse with the cis 
face of the Golgi apparatus 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Golgi Apparatus 
 Proteins then pass through the Golgi apparatus to 
the trans face 
 Secretory vesicles leave the trans face of the Golgi 
stack and move to designated parts of the cell 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Golgi Apparatus 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.20a
Role of the Golgi Apparatus 
Cisterna Rough ER 
Golgi 
apparatus 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Plasma membrane 
Figure 3.21 
Lysosomes containing acid 
hydrolase enzymes 
Vesicle incorporated 
into plasma membrane 
Secretion by exocytosis 
Extracellular fluid 
Coatomer 
coat 
Phagosome 
Proteins in cisterna 
Membrane 
Vesicle 
Pathway 3 
Pathway 2 
Secretory vesicles 
Proteins 
Pathway 1
Role of the Golgi Apparatus 
Cisterna Rough ER 
Golgi 
apparatus 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.21 
Secretion by exocytosis 
Extracellular fluid 
Proteins in cisterna 
Membrane 
Vesicle 
Secretory vesicles 
Proteins 
Pathway 1
Role of the Golgi Apparatus 
Proteins in cisterna 
Membrane 
Vesicle 
Cisterna Rough ER 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Plasma membrane 
Figure 3.21 
Vesicle incorporated 
into plasma membrane 
Secretion by exocytosis 
Extracellular fluid 
Coatomer 
coat 
Pathway 2 
Golgi 
apparatus
Role of the Golgi Apparatus 
Proteins in cisterna 
Cisterna Rough ER 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Plasma membrane 
Phagosome 
Extracellular fluid 
Figure 3.21 
Lysosomes containing acid 
hydrolase enzymes 
Membrane 
Vesicle 
Pathway 3 
Secretory vesicles 
Golgi 
apparatus
Role of the Golgi Apparatus 
Cisterna Rough ER 
Golgi 
apparatus 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Plasma membrane 
Figure 3.21 
Lysosomes containing acid 
hydrolase enzymes 
Vesicle incorporated 
into plasma membrane 
Secretion by exocytosis 
Extracellular fluid 
Coatomer 
coat 
Phagosome 
Proteins in cisterna 
Membrane 
Vesicle 
Pathway 3 
Pathway 2 
Secretory vesicles 
Proteins 
Pathway 1
Lysosomes 
 Spherical membranous bags containing digestive 
enzymes 
 Digest ingested bacteria, viruses, and toxins 
 Degrade nonfunctional organelles 
 Breakdown glycogen and release thyroid hormone 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Lysosomes 
 Breakdown nonuseful tissue 
 Breakdown bone to release Ca2+ 
 Secretory lysosomes are found in white blood 
cells, immune cells, and melanocytes 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Endomembrane System 
 System of organelles that function to: 
 Produce, store, and export biological molecules 
 Degrade potentially harmful substances 
 System includes: 
 Nuclear envelope, smooth and rough ER, 
lysosomes, vacuoles, transport vesicles, Golgi 
apparatus, and the plasma membrane 
PPLLAAYY Endomembrane System 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Endomembrane System 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.23
Peroxisomes 
 Membranous sacs containing oxidases and 
catalases 
 Detoxify harmful or toxic substances 
 Neutralize dangerous free radicals 
 Free radicals – highly reactive chemicals with 
unpaired electrons (i.e., O2 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
–)
Cytoskeleton 
 The “skeleton” of the cell 
 Dynamic, elaborate series of rods running through 
the cytosol 
 Consists of microtubules, microfilaments, and 
intermediate filaments 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Cytoskeleton 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.24a-b
Cytoskeleton 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.24c
Microtubules 
 Dynamic, hollow tubes made of the spherical 
protein tubulin 
 Determine the overall shape of the cell and 
distribution of organelles 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Microfilaments 
 Dynamic strands of the protein actin 
 Attached to the cytoplasmic side of the plasma 
membrane 
 Braces and strengthens the cell surface 
 Attach to CAMs and function in endocytosis and 
exocytosis 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Intermediate Filaments 
 Tough, insoluble protein fibers with high tensile 
strength 
 Resist pulling forces on the cell and help form 
desmosomes 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Motor Molecules 
 Protein complexes that function in motility 
 Powered by ATP 
 Attach to receptors on organelles 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Motor Molecules 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.25a
Motor Molecules 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.25b
Centrioles 
 Small barrel-shaped organelles located in the 
centrosome near the nucleus 
 Pinwheel array of nine triplets of microtubules 
 Organize mitotic spindle during mitosis 
 Form the bases of cilia and flagella 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Centrioles 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.26a, b
Cilia 
 Whip-like, motile cellular extensions on exposed 
surfaces of certain cells 
 Move substances in one direction across cell 
surfaces 
PPLLAAYY Cilia and Flagella 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Cilia 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.27a
Cilia 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.27b
Cilia 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.27c
Nucleus 
 Contains nuclear envelope, nucleoli, chromatin, 
and distinct compartments rich in specific protein 
sets 
 Gene-containing control center of the cell 
 Contains the genetic library with blueprints for 
nearly all cellular proteins 
 Dictates the kinds and amounts of proteins to be 
synthesized 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Nucleus 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.28a
Nuclear Envelope 
 Selectively permeable double membrane barrier 
containing pores 
 Encloses jellylike nucleoplasm, which contains 
essential solutes 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Nuclear Envelope 
 Outer membrane is continuous with the rough ER 
and is studded with ribosomes 
 Inner membrane is lined with the nuclear lamina, 
which maintains the shape of the nucleus 
 Pore complex regulates transport of large 
molecules into and out of the nucleus 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Nucleoli 
 Dark-staining spherical bodies within the nucleus 
 Site of ribosome production 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
Chromatin 
 Threadlike strands of 
DNA and histones 
 Arranged in 
fundamental units 
called nucleosomes 
 Form condensed, 
barlike bodies of 
chromosomes when 
the nucleus starts to 
divide 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings 
Figure 3.29
Cell Cycle 
 Interphase 
 Growth (G1), 
synthesis (S), 
growth (G2) 
 Mitotic phase 
 Mitosis and 
cytokinesis 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.30
Interphase 
 G1 (gap 1) – metabolic activity and vigorous 
growth 
 G0 – cells that permanently cease dividing 
 S (synthetic) – DNA replication 
 G2 (gap 2) – preparation for division 
PPLLAAYY Late Interphase 
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings

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Ch03 c,living uints,mission

  • 1. Human Anatomy & Physiology SEVENTH EDITION Elaine N. Marieb Katja Hoehn Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint® Lecture Slides prepared by Vince Austin, Bluegrass Technical and Community College C H A P T E R 3Cells: The P A R T C Living Units
  • 2. Golgi Apparatus  Stacked and flattened membranous sacs  Functions in modification, concentration, and packaging of proteins  Transport vessels from the ER fuse with the cis face of the Golgi apparatus Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 3. Golgi Apparatus  Proteins then pass through the Golgi apparatus to the trans face  Secretory vesicles leave the trans face of the Golgi stack and move to designated parts of the cell Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 4. Golgi Apparatus Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.20a
  • 5. Role of the Golgi Apparatus Cisterna Rough ER Golgi apparatus Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Plasma membrane Figure 3.21 Lysosomes containing acid hydrolase enzymes Vesicle incorporated into plasma membrane Secretion by exocytosis Extracellular fluid Coatomer coat Phagosome Proteins in cisterna Membrane Vesicle Pathway 3 Pathway 2 Secretory vesicles Proteins Pathway 1
  • 6. Role of the Golgi Apparatus Cisterna Rough ER Golgi apparatus Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.21 Secretion by exocytosis Extracellular fluid Proteins in cisterna Membrane Vesicle Secretory vesicles Proteins Pathway 1
  • 7. Role of the Golgi Apparatus Proteins in cisterna Membrane Vesicle Cisterna Rough ER Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Plasma membrane Figure 3.21 Vesicle incorporated into plasma membrane Secretion by exocytosis Extracellular fluid Coatomer coat Pathway 2 Golgi apparatus
  • 8. Role of the Golgi Apparatus Proteins in cisterna Cisterna Rough ER Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Plasma membrane Phagosome Extracellular fluid Figure 3.21 Lysosomes containing acid hydrolase enzymes Membrane Vesicle Pathway 3 Secretory vesicles Golgi apparatus
  • 9. Role of the Golgi Apparatus Cisterna Rough ER Golgi apparatus Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Plasma membrane Figure 3.21 Lysosomes containing acid hydrolase enzymes Vesicle incorporated into plasma membrane Secretion by exocytosis Extracellular fluid Coatomer coat Phagosome Proteins in cisterna Membrane Vesicle Pathway 3 Pathway 2 Secretory vesicles Proteins Pathway 1
  • 10. Lysosomes  Spherical membranous bags containing digestive enzymes  Digest ingested bacteria, viruses, and toxins  Degrade nonfunctional organelles  Breakdown glycogen and release thyroid hormone Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 11. Lysosomes  Breakdown nonuseful tissue  Breakdown bone to release Ca2+  Secretory lysosomes are found in white blood cells, immune cells, and melanocytes Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 12. Endomembrane System  System of organelles that function to:  Produce, store, and export biological molecules  Degrade potentially harmful substances  System includes:  Nuclear envelope, smooth and rough ER, lysosomes, vacuoles, transport vesicles, Golgi apparatus, and the plasma membrane PPLLAAYY Endomembrane System Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 13. Endomembrane System Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.23
  • 14. Peroxisomes  Membranous sacs containing oxidases and catalases  Detoxify harmful or toxic substances  Neutralize dangerous free radicals  Free radicals – highly reactive chemicals with unpaired electrons (i.e., O2 Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings –)
  • 15. Cytoskeleton  The “skeleton” of the cell  Dynamic, elaborate series of rods running through the cytosol  Consists of microtubules, microfilaments, and intermediate filaments Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 16. Cytoskeleton Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.24a-b
  • 17. Cytoskeleton Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.24c
  • 18. Microtubules  Dynamic, hollow tubes made of the spherical protein tubulin  Determine the overall shape of the cell and distribution of organelles Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 19. Microfilaments  Dynamic strands of the protein actin  Attached to the cytoplasmic side of the plasma membrane  Braces and strengthens the cell surface  Attach to CAMs and function in endocytosis and exocytosis Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 20. Intermediate Filaments  Tough, insoluble protein fibers with high tensile strength  Resist pulling forces on the cell and help form desmosomes Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 21. Motor Molecules  Protein complexes that function in motility  Powered by ATP  Attach to receptors on organelles Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 22. Motor Molecules Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.25a
  • 23. Motor Molecules Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.25b
  • 24. Centrioles  Small barrel-shaped organelles located in the centrosome near the nucleus  Pinwheel array of nine triplets of microtubules  Organize mitotic spindle during mitosis  Form the bases of cilia and flagella Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 25. Centrioles Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.26a, b
  • 26. Cilia  Whip-like, motile cellular extensions on exposed surfaces of certain cells  Move substances in one direction across cell surfaces PPLLAAYY Cilia and Flagella Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 27. Cilia Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.27a
  • 28. Cilia Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.27b
  • 29. Cilia Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.27c
  • 30. Nucleus  Contains nuclear envelope, nucleoli, chromatin, and distinct compartments rich in specific protein sets  Gene-containing control center of the cell  Contains the genetic library with blueprints for nearly all cellular proteins  Dictates the kinds and amounts of proteins to be synthesized Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 31. Nucleus Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.28a
  • 32. Nuclear Envelope  Selectively permeable double membrane barrier containing pores  Encloses jellylike nucleoplasm, which contains essential solutes Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 33. Nuclear Envelope  Outer membrane is continuous with the rough ER and is studded with ribosomes  Inner membrane is lined with the nuclear lamina, which maintains the shape of the nucleus  Pore complex regulates transport of large molecules into and out of the nucleus Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 34. Nucleoli  Dark-staining spherical bodies within the nucleus  Site of ribosome production Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
  • 35. Chromatin  Threadlike strands of DNA and histones  Arranged in fundamental units called nucleosomes  Form condensed, barlike bodies of chromosomes when the nucleus starts to divide Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.29
  • 36. Cell Cycle  Interphase  Growth (G1), synthesis (S), growth (G2)  Mitotic phase  Mitosis and cytokinesis Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3.30
  • 37. Interphase  G1 (gap 1) – metabolic activity and vigorous growth  G0 – cells that permanently cease dividing  S (synthetic) – DNA replication  G2 (gap 2) – preparation for division PPLLAAYY Late Interphase Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings