Corrosive ingestions can cause severe damage to the esophagus and stomach. The severity depends on the properties of the ingested agent, amount, concentration, and duration of contact. Endoscopy within 24 hours is recommended for most patients to assess injury, except those with signs of perforation or respiratory distress. Patients with moderate to severe injury require intensive care monitoring for complications like perforation. Gentle endoscopic dilation is used to treat stricture, while surgery is reserved for emergency situations or after fibrotic changes occur. There is debate around prophylactic antibiotic and steroid use.
3. Corrosive injuries
Ingestion can be accidental or suicidal
Most ingestion occurs in children and the remainder in
psychotic, suicidal, and alcoholic subjects
Cause severe damage to the mouth, pharynx, larynx,
esophagus and stomach
The type of agent, its concentration, volume ingested and
the duration of mucosal contact largely determine the
extent of damage
4. Alkali vs Acid injuries
ACID
• Acids are potent dessicants
• Cause coagulative necrosis with
eschar formation
• Eschar may limit penetration to
deeper layers of the oesophageal
wall
• Induce intense pylorospasm with
pooling in the antrum
• More gastric damage than alkalis
AKALI
• Alkalis cause liquefaction necrosis,
saponification of fats, dehydration
and thrombosis of blood vessels
• No eschar formation, hence
deeper injuries
• Usually leads to fibrous scarring
• More esophageal damage than
stomach and duodenum
• Do not induce pylorospasm
5. Pathology
Phases of tissue injury in corrosive ingestion
Phase 1: Acute necrosis— 1-4 days
Phase 2: Ulceration— granulation— 4-12 days
Phase 3: Cicatrisation and scarring— 3 weeks-6 months
Degrees of burns
1st degree: [Mucosal] Mucosal hyperaemia and oedema
2nd degree: [Mucosal & Submucosal] Small bleeding, exudates,
ulcers, pseudomembrane
3rd degree: [Transmural] Mucosal slough, deep ulcers, massive
bleed, complete obstruction, charring, perforation
6. Clinical features
Symptoms and signs unreliable in predicting the severity
of injury
Common presentation
• Oropharyngeal, retrosternal or
epigastric pain
• Dysphagia/odynophagia
• Hypersalivation
• Vomiting
• Hematemesis
Burns of the epiglottis & larynx
Hoarseness, stridor, aphonia and
respiratory difficulties
Perforation /with
peritonitis
Persistent, localized
abdominal tenderness,
rebound, and rigidity
7. General Management
Asymptomatic pt. who gives a reliable history of a low volume,
accidental ingestion of low concentration; endoscopy may not be
necessary Discharged and F/U in OPD
Cases of suspected significant ingestion generally be treated in a
surgical or medical ICUs
NPO, Hemodynamic stability, PPIs, Adequate analgesia
Assess signs of perforation, mediastinitis or peritonitis– need Em.
Surgery
Assess need for ET intubation or tracheostomy
Management
8. General Management
Use of emetics, neutralizing agents, or nasogastric intubation to
remove remaining corrosive material is contraindicated
In most patients, gastrointestinal endoscopy should be
performed during the first 24 hours
Contraindication: hemodynamic instability, evidence of
perforation, severe respiratory distress, or severe
oropharyngeal or glottic edema and necrosis
9. In 1st degree burns:
48 hours observation; oral feeds are started once patient swallows saliva
painlessly.
Regular follow-up endoscopy at 1st, 2nd and 8th months. Stricture if
formed can be identified by this time.
2nd and 3rd degree burns:
They are treated with fluid therapy, antibiotics, nutrition, PPIs, aerosolised
steroids
Fiberoptic guided airway intubation if needed tracheostomy;
Endoscopic oesophageal stenting, feeding jejunostomy, laparoscopy for
evaluation
Management
10. Careful early gentle repeated endoscopy is mandatory
Regular oesophageal dilatation is done for stricture
Stricture is dilated endoscopically using guidewire
Dilators are solid type with gradual increase in diameters
Often radiologic C-ARM guidance is needed to pass the guide
wire into the stomach
Dilatation should be done up to minimum 16 mm diameter.
Earlier, blind dilatation using oesophageal bougies of increased diameters
was the practice, which is followed even now in many places, but chances
of perforation is more.
Pneumatic or balloon dilatation, Gum elastic dilators, mercury weighted
dilators, Eder-Puestow dilators, Savary-Gilliard dilators, balloon dilators are
other dilators used
Other than emergency surgery for bleeding or
perforation, elective oesophageal resection should be
deferred for at least three months until the fibrotic
phase is established
11. Oesophageal resection in corrosive strictures is technically
difficult and may be hazardous
Oesophageal bypass is better and easier, and following
later by regular endoscopic surveillance for malignant
transformation (5%)
Colon is used as replacing conduit as stomach itself may be
diseased in corrosive pathology
In multiple strictures oesophageal resection and colonic
transposition may be advocated if risk of malignancy is
considered
12. Where is the controversy?
Use of broad spectrum antibiotics and steroids
[Benefits not supported by evidence]
Regarding risk of developing carcinoma in the
damaged oesophagus and stomach and how
this might influence management
13. Summary
Severity and extent of damage depend upon:
Corrosive properties; amount, concentration, and physical form of the agent; and the
duration of contact with the mucosa
Absence of oropharyngeal burns does not preclude the presence of
esophageal or gastric injury
Use of emetics, neutralizing agents, or nasogastric intubation to remove
remaining corrosive material is contraindicated
In most patients, gastrointestinal endoscopy should be performed during the
first 24 hours
Contraindication: hemodynamic instability, evidence of perforation, severe respiratory
distress, or severe oropharyngeal or glottic edema and necrosis
Patients with moderate to severe injury require management in an intensive
care unit to monitor for potential life-threatening complications
Clinical signs of perforation, mediastinitis or peritonitis are indications for
emergency surgery