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PREDICTION OF HEART FAILURE CONDITION AND SURVIVAL
METHODS USING MACHINE LEARNING
INTRODUCTION
 The number of people with heart failure has increased rapidly worldwide.
 Several different symptoms are associated with heart disease, which makes it
difficult to diagnose it quicker and better.
 This issue can be resolved by adopting machine learning techniques.
 There are conflicting views and an overall lack of research as to how best to
manage these heart failure conditions and their survival methods.
OBJECTIVES
Several researchers use machine learning techniques for predicting HF conditions.
Yet, these researchers compared a set of machine learning algorithms with some
simple primitive techniques. This inspired me to think about the complexity of
machine learning algorithms for predicting heart failure and to assess the methods
using a common benchmark dataset.
RESEARCH QUESTIONS
 Which type of machine learning algorithms are used for predicting heart disease?
 Most effective machine learning approach to evaluate heart failure conditions and
their survival methods?
 Which variable can cause heart failure condition more?
PROGRAMMING RESOURCES & MLAlgorithms
 Open-source IDE called RStudio. The programs are written in R script. Windows 10
system is used for these purposes.
 Standard UCI Cleveland cardiac disease dataset is retrieved from the Kaggle
database.
 Machine learning algorithms used for testing the results are,
1. Linear regression
2. Logistic regression
3. Decision tree
4. Random forest
5. Artificial Neural Network
6. K-Nearest Neighbor
7. Support Vector Machine
8. Naive Bayes
9. Gradient Boosting
METHODOLOGY
Splitting
Dataset
Data
Collection
Dataset creation
Loading
manipulation
Data
cleaning &
pre-
processing
1. Missing values
2. Outlier detection
Data
Visualizati
on
Boxplot
Bar chart
Q-Q plot
Histogram
Data
Exploration
Correlation analysis
Partial correlation
Hypothesis
testing(KS test)
Factor analysis
Model
Creation &
Evaluation
Survival
Methods
GUI
Modelling
DATA VISUALIZATION
DATA EXPLORATION
 Both the spearman correlation method and the pearson
correlation approach can be used to determine the
connection.
 Variables chosen after factor reduction are age, bp,
FBS.Over.120, cholesterol, sex, exercise.Angina,
ST.Depression, and slope.Of.St
 After analysing the partial correlation across the terms,
we could find that the terms age, BP, FBS.Over.120,
cholesterol, sex, exercise.Angina, ST.Depression, and
slope.Of.ST shows a positive estimate value, which
means a strong correlation with total heart disease. So,
for further analysis, I could select the above variables.

MODEL CREATION AND EVALUATION
SURVIVAL METHODS
NON- PARAMETRIC SURVIVAL
METHOD
• KAPLAN-MEIER SURVIVAL METHOD
PARAMETRIC SURVIVAL METHOD
• EXPONENTIAL MODEL
• LOG-NORMAL MODEL
• COX PROPORTIONAL HAZARD
MODEL
GRAPHICAL USER INTERFACE (GUI)
CONCLUSION
1. Which type of machine learning algorithms are used for predicting heart disease?
Decision tree, logistic regression, linear regression, k-Nearest Neighbor, random forest, Gradient
boosting, Artificial neural network, Naïve Bayes, and Support vector machine.
2. Most effective machine learning approach to evaluate heart failure conditions and their survival
methods?
Linear Regression and Naive Bayes seem to be the best models, with the highest accuracy of
0.8518519. Here I used a non-parametric method like the Kaplan-Meier survival curve and
parametric survival methods like the Exponential model, Log – Normal model and Cox proportional
hazard model (which is a semi-parametric model).
3. Which variable can cause heart failure condition more?
variables Age, Blood Pressure, Maximum Heart Rate, Thallium, Number of vessels Fluro, and Age
can cause heart failure condition more.
REFERENCE
Ahmad, T., Lund, L. H., Rao, P., Ghosh, R., Warier, P., Vaccaro, B., Dahlström, U., O’Connor, C. M., Michael Felker, G., & Desai, N. R. (2018). Machine learning methods
improve prognostication, identify clinically distinct phenotypes, and detect heterogeneity in response to therapy in a large cohort of heart failure patients. Journal of the
American Heart Association, 7(8). https://doi.org/10.1161/JAHA.117.008081
Almazroi, A. A. (2022). Survival prediction among heart patients using machine learning techniques. Mathematical Biosciences and Engineering, 19(1), 134–145.
https://doi.org/10.3934/mbe.2022007
Angraal, S., Mortazavi, B. J., Gupta, A., Khera, R., Ahmad, T., Desai, N. R., Jacoby, D. L., Masoudi, F. A., Spertus, J. A., & Krumholz, H. M. (2020). Machine Learning
Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction. JACC: Heart Failure, 8(1), 12–21. https://doi.org/10.1016/j.jchf.2019.06.013
Chicco, D., & Jurman, G. (2020). Machine learning can predict survival of patients with heart failure from serum creatinine and ejection fraction alone. BMC Medical
Informatics and Decision Making, 20(1). https://doi.org/10.1186/s12911-020-1023-5
Dinesh Kumar G, Arumugaraj K, Mareeswari V, & Santhosh Kumar D. (2018). Proceedings of the 2018 International Conference on Current Trends towards Converging
Technologies : 01-03, March 2018 (IEEE access).
Elyassami, S., & Kaddour, A. A. (2021). Implementation of an incremental deep learning model for survival prediction of cardiovascular patients. IAES International Journal of
Artificial Intelligence, 10(1), 101–109. https://doi.org/10.11591/ijai.v10.i1.pp101-109
FEDESORIANO. (2021, September). Heart Failure Prediction Dataset. Https://Www.Kaggle.Com/Fedesoriano/Heart-Failure-Prediction.
Feng, Y., Leung, A. A., Lu, X., Liang, Z., Quan, H., & Walker, R. L. (2022). Personalized prediction of incident hospitalization for cardiovascular disease in patients with
hypertension using machine learning. BMC Medical Research Methodology, 22(1). https://doi.org/10.1186/s12874-022-01814-3
Gupta, A., Kumar, R., Singh Arora, H., & Raman, B. (2020). MIFH: A Machine Intelligence Framework for Heart Disease Diagnosis. IEEE Access, 8, 14659–14674.
https://doi.org/10.1109/ACCESS.2019.2962755
Ishaq, A., Sadiq, S., Umer, M., Ullah, S., Mirjalili, S., Rupapara, V., & Nappi, M. (2021). Improving the Prediction of Heart Failure Patients’ Survival Using SMOTE and
Effective Data Mining Techniques. IEEE Access, 9, 39707–39716. https://doi.org/10.1109/ACCESS.2021.3064084
Janssens, A. C. J. W., Ioannidis, J. P. A., Bedrosian, S., Boffetta, P., Dolan, S. M., Dowling, N., Fortier, I., Freedman, A. N., Grimshaw, J. M., Gulcher, J., Gwinn, M., Hlatky,
M. A., Janes, H., Kraft, P., Melillo, S., O’Donnell, C. J., Pencina, M. J., Ransohoff, D., Schully, S. D., … Khoury, M. J. (2011). Strengthening the reporting of genetic risk
prediction studies (GRIPS): Explanation and elaboration. In European Journal of Epidemiology (Vol. 26, Issue 4, pp. 313–337). https://doi.org/10.1007/s10654-011-9551-z
Jing, L., Ulloa Cerna, A. E., Good, C. W., Sauers, N. M., Schneider, G., Hartzel, D. N., Leader, J. B., Kirchner, H. L., Hu, Y., Riviello, D. M., Stough, J. V., Gazes, S.,
Haggerty, A., Raghunath, S., Carry, B. J., Haggerty, C. M., & Fornwalt, B. K. (2020). A Machine Learning Approach to Management of Heart Failure Populations. JACC:
Heart Failure, 8(7), 578–587. https://doi.org/10.1016/j.jchf.2020.01.012
Li Guo, Yuefeng Du, Man Li, Euxu Xie, Chen Ma, & Xuelian Gu. (2021, October 5). Development and Validation of a Nomogram for Predicting Bladder Calculi Risk in
Patients With Benign Prostatic Hyperplasia. Research Square.
THANKYOU
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Dissertation PPT.pptx

  • 1. PREDICTION OF HEART FAILURE CONDITION AND SURVIVAL METHODS USING MACHINE LEARNING
  • 2. INTRODUCTION  The number of people with heart failure has increased rapidly worldwide.  Several different symptoms are associated with heart disease, which makes it difficult to diagnose it quicker and better.  This issue can be resolved by adopting machine learning techniques.  There are conflicting views and an overall lack of research as to how best to manage these heart failure conditions and their survival methods.
  • 3. OBJECTIVES Several researchers use machine learning techniques for predicting HF conditions. Yet, these researchers compared a set of machine learning algorithms with some simple primitive techniques. This inspired me to think about the complexity of machine learning algorithms for predicting heart failure and to assess the methods using a common benchmark dataset. RESEARCH QUESTIONS  Which type of machine learning algorithms are used for predicting heart disease?  Most effective machine learning approach to evaluate heart failure conditions and their survival methods?  Which variable can cause heart failure condition more?
  • 4. PROGRAMMING RESOURCES & MLAlgorithms  Open-source IDE called RStudio. The programs are written in R script. Windows 10 system is used for these purposes.  Standard UCI Cleveland cardiac disease dataset is retrieved from the Kaggle database.  Machine learning algorithms used for testing the results are, 1. Linear regression 2. Logistic regression 3. Decision tree 4. Random forest 5. Artificial Neural Network 6. K-Nearest Neighbor 7. Support Vector Machine 8. Naive Bayes 9. Gradient Boosting
  • 5. METHODOLOGY Splitting Dataset Data Collection Dataset creation Loading manipulation Data cleaning & pre- processing 1. Missing values 2. Outlier detection Data Visualizati on Boxplot Bar chart Q-Q plot Histogram Data Exploration Correlation analysis Partial correlation Hypothesis testing(KS test) Factor analysis Model Creation & Evaluation Survival Methods GUI Modelling
  • 7. DATA EXPLORATION  Both the spearman correlation method and the pearson correlation approach can be used to determine the connection.  Variables chosen after factor reduction are age, bp, FBS.Over.120, cholesterol, sex, exercise.Angina, ST.Depression, and slope.Of.St  After analysing the partial correlation across the terms, we could find that the terms age, BP, FBS.Over.120, cholesterol, sex, exercise.Angina, ST.Depression, and slope.Of.ST shows a positive estimate value, which means a strong correlation with total heart disease. So, for further analysis, I could select the above variables. 
  • 8. MODEL CREATION AND EVALUATION
  • 9.
  • 10. SURVIVAL METHODS NON- PARAMETRIC SURVIVAL METHOD • KAPLAN-MEIER SURVIVAL METHOD PARAMETRIC SURVIVAL METHOD • EXPONENTIAL MODEL • LOG-NORMAL MODEL • COX PROPORTIONAL HAZARD MODEL
  • 12. CONCLUSION 1. Which type of machine learning algorithms are used for predicting heart disease? Decision tree, logistic regression, linear regression, k-Nearest Neighbor, random forest, Gradient boosting, Artificial neural network, Naïve Bayes, and Support vector machine. 2. Most effective machine learning approach to evaluate heart failure conditions and their survival methods? Linear Regression and Naive Bayes seem to be the best models, with the highest accuracy of 0.8518519. Here I used a non-parametric method like the Kaplan-Meier survival curve and parametric survival methods like the Exponential model, Log – Normal model and Cox proportional hazard model (which is a semi-parametric model). 3. Which variable can cause heart failure condition more? variables Age, Blood Pressure, Maximum Heart Rate, Thallium, Number of vessels Fluro, and Age can cause heart failure condition more.
  • 13. REFERENCE Ahmad, T., Lund, L. H., Rao, P., Ghosh, R., Warier, P., Vaccaro, B., Dahlström, U., O’Connor, C. M., Michael Felker, G., & Desai, N. R. (2018). Machine learning methods improve prognostication, identify clinically distinct phenotypes, and detect heterogeneity in response to therapy in a large cohort of heart failure patients. Journal of the American Heart Association, 7(8). https://doi.org/10.1161/JAHA.117.008081 Almazroi, A. A. (2022). Survival prediction among heart patients using machine learning techniques. Mathematical Biosciences and Engineering, 19(1), 134–145. https://doi.org/10.3934/mbe.2022007 Angraal, S., Mortazavi, B. J., Gupta, A., Khera, R., Ahmad, T., Desai, N. R., Jacoby, D. L., Masoudi, F. A., Spertus, J. A., & Krumholz, H. M. (2020). Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction. JACC: Heart Failure, 8(1), 12–21. https://doi.org/10.1016/j.jchf.2019.06.013 Chicco, D., & Jurman, G. (2020). Machine learning can predict survival of patients with heart failure from serum creatinine and ejection fraction alone. BMC Medical Informatics and Decision Making, 20(1). https://doi.org/10.1186/s12911-020-1023-5 Dinesh Kumar G, Arumugaraj K, Mareeswari V, & Santhosh Kumar D. (2018). Proceedings of the 2018 International Conference on Current Trends towards Converging Technologies : 01-03, March 2018 (IEEE access). Elyassami, S., & Kaddour, A. A. (2021). Implementation of an incremental deep learning model for survival prediction of cardiovascular patients. IAES International Journal of Artificial Intelligence, 10(1), 101–109. https://doi.org/10.11591/ijai.v10.i1.pp101-109 FEDESORIANO. (2021, September). Heart Failure Prediction Dataset. Https://Www.Kaggle.Com/Fedesoriano/Heart-Failure-Prediction. Feng, Y., Leung, A. A., Lu, X., Liang, Z., Quan, H., & Walker, R. L. (2022). Personalized prediction of incident hospitalization for cardiovascular disease in patients with hypertension using machine learning. BMC Medical Research Methodology, 22(1). https://doi.org/10.1186/s12874-022-01814-3 Gupta, A., Kumar, R., Singh Arora, H., & Raman, B. (2020). MIFH: A Machine Intelligence Framework for Heart Disease Diagnosis. IEEE Access, 8, 14659–14674. https://doi.org/10.1109/ACCESS.2019.2962755 Ishaq, A., Sadiq, S., Umer, M., Ullah, S., Mirjalili, S., Rupapara, V., & Nappi, M. (2021). Improving the Prediction of Heart Failure Patients’ Survival Using SMOTE and Effective Data Mining Techniques. IEEE Access, 9, 39707–39716. https://doi.org/10.1109/ACCESS.2021.3064084 Janssens, A. C. J. W., Ioannidis, J. P. A., Bedrosian, S., Boffetta, P., Dolan, S. M., Dowling, N., Fortier, I., Freedman, A. N., Grimshaw, J. M., Gulcher, J., Gwinn, M., Hlatky, M. A., Janes, H., Kraft, P., Melillo, S., O’Donnell, C. J., Pencina, M. J., Ransohoff, D., Schully, S. D., … Khoury, M. J. (2011). Strengthening the reporting of genetic risk prediction studies (GRIPS): Explanation and elaboration. In European Journal of Epidemiology (Vol. 26, Issue 4, pp. 313–337). https://doi.org/10.1007/s10654-011-9551-z Jing, L., Ulloa Cerna, A. E., Good, C. W., Sauers, N. M., Schneider, G., Hartzel, D. N., Leader, J. B., Kirchner, H. L., Hu, Y., Riviello, D. M., Stough, J. V., Gazes, S., Haggerty, A., Raghunath, S., Carry, B. J., Haggerty, C. M., & Fornwalt, B. K. (2020). A Machine Learning Approach to Management of Heart Failure Populations. JACC: Heart Failure, 8(7), 578–587. https://doi.org/10.1016/j.jchf.2020.01.012 Li Guo, Yuefeng Du, Man Li, Euxu Xie, Chen Ma, & Xuelian Gu. (2021, October 5). Development and Validation of a Nomogram for Predicting Bladder Calculi Risk in Patients With Benign Prostatic Hyperplasia. Research Square.