1. How Good Is “Evidence” From Clinical
Studies Of Drug Effects and Why Might
Such Evidence Fail in the Prediction of the
Clinical Utility of Drugs?
O (Naci H.,Ioannidis
P.A.,Annu.Rev.Pharmacol.Toxicol.,2015,55:169-189)
1
SUJITA MISHRA
PI/289
5. Problems in the Design of Clinical Studies of
Drug Effects
Insufficient Considerations Of Evidence
Use Of Weak Study Designs
Industry Sponsorship Of Research
Lack Of Head–to-Head Comparisons
Choice Of Patient Population
Choice Of Outcomes
5
6. Insufficient Considerations of Evidence
Continuously
Updated
Assessments
Published Reports
May Not Cited
Focus On
Consulting Reviews
Disproportionate
research
6
7. Use Of Weak Study Designs
NON-RANDOMIZED
DESIGNS
RANDOMIZED DESIGNS
7
8. Industry Sponsorship Of Research
Most Clinical Drug Research Is Sponsored by
Pharmaceutical Industry
Industry Sponsored Studies Favour the Products
Funded by Other Sources
8
15. Problems in the Evidence and in the Formation
of Recommendations from Studies of Drug
Effects
METAANALYSES
RELIABILITY OF CLINICAL PRACTICE
GUIDELINES
15
16. Solution of Clinical Trial’s Problems
16
Potential Improvements
Study Registrations
Provision Of Raw Data
17. Solution of Clinical Trial’s Problems
17
Sponsoring of Clinical Research by
Nonconflicted Entities
Requirement of Comparative Data at the Time
of Drug Approvals
Nonconflicted Conduct Of Systematic
Reviews
19. Conclusions
19
Cite existing or Prior
reviews first
Clinical Agendas are
Mostly in Favor with
Industry
Tackle the Numerous
Defects in Clinical Trials
Scientific Scrutiny
Before Implemented
20. Acknowledgments
O I wish to acknowledge to-
O Dr.SACHCHIDANAND SIR,
O Dr.M.CHOURASIA SIR,
O Dr.SHAILENDRA SIR,
O SOHNI MAM, and
O MY CLASSMATES.
O I THANK YOU ALL……
20