Compound Syrup

1. To prepare and submit compound syrup of
ferrous phosphate BPC 1968.
Experiment No.2
Presented by Miss Sudipta Roy

2. • Theory of this practical :
• Ferrous phosphate syrup is prepared by chemical reaction between iron
and phosphoric acid and other electrolyte supplements like calcium
carbonate , potassium bicarbonate and sodium phosphate.
• The electrolytes such as calcium (Ca++) , Sodium (Na++) and Potassium
(K+) are also supplied in phosphate form.
• In this preparation, half of portion of phosphoric acid reacts with iron
and forms ferrous acid phosphate. Remaining half of the portion of
phosphoric acid reacts with calcium carbonate, potassium bi carbonate
and sodium phosphate and forms corresponding phosphates.
• But the amount of phosphoric acid is insufficient to complete this
reaction. Hence the excess of acid phosphate present in ferrous acid
phosphate {Fe(H2PO4)2} is used to complete this reaction.

3. • The following reactions takes place, during the preparation of ferrous phosphate syrup.
• Fe + H3PO4 = Fe(H2PO4)2 + H2O
• Iron Phosphoric Acid Ferrous acid phosphate
• CaCO3 + 2H3PO4 = Ca(H2PO4)2 + CO2 + H2O
• Calcium Carbonate Calcium dihydrogen phosphate
• KHCO3 + 2H3PO4 = KH2PO4 + CO2 + H2O
• Potassium Carbonate Potassium dihydrogen phosphate
• Na2HPO4 + 2H3PO4 = NaH2PO4 + CO2 + H2O
• Sodium Phosphate Sodium dihydrogen phosphate
• Cochineal is used as colouring agent, which is obtained by aqueous extraction of cochineal . In
this preparation it is used as masking agent to mask, if any colour change of the preparation
occurs , due to oxidation of constituents during storage.
• Orange flower water is used as flavouring agent. Sucrose is used to prepare syrup, which is used
as sweetening agent to mask the specific iron taste of the preparation. It also helps in giving
viscous nature to the preparation and also acts as preservative, because of its higher
concentration.

4. • Requirements :
• Apparatus : Weighing Balance, Beaker , Stirrer ,
conical flask, measuring cylinder , water bath etc.
• Chemicals : Iron phosphoric acid, Calcium
Carbonate , Potassium Coarbonate , Sodium
Phosphate , Cochineal , Sucrose , Orange flavour
water of commerce, Undiluted and Purified water.

5. • Procedure :
• Clean all the glassware and dry them properly as per sop.
• Dilute half the quantity of phosphoric acid with little
amount of water and iron to it.
• Gently heat this solution on a water bathn until iron gets
dissolved.
• In a separate beaker transfer remaining portion of
phosphoric acid and add calcium carbonate, potassium bi
carbonate, sodium phosphate with continuous stirring. All
step CO2 will release and allow CO2 to evolve
completely.

6. • Mix both the solution with stirring and allow to stand for
few minutes to complete the reaction in a conical flask.
Boil cochineal in water for 15 min. Cool , strain and pass
sufficient water through the stainless. To this add sucrose
and again boil for 15 minutes to form colored syrup.
• Filtered iron slution into the colored syrup , to add orange
flavoured water to pass sufficient water through the filter
to produce the required volume to mix allow standing for
cooling and filter of necessary.
• Transfer preparation for narrow mouth coloured glass
bottle clot , to close with cap label and submit.

7. • Category : Iron and Electrolyte (Calcium, potassium,
sodium) supplement in anemic patient.
• Storage : Store in well closed container in cool and
dark place.
• Result : 10 ml of compound syrup of Ferrous
Phosphate BPC 1968 preparation is submtted in
well closed amber colored container with neat
label.

8. Ingredients Quantity Given Quantity Taken
(Factor * Quantity given )
Factor Calculation.
Iron
Phosphoric Acid
Calcium Carbonate
Potassium bicarbonate
Sodium Phosphate
Cochineal
Sucrose
Orange , Flower water
Purified Water, Sufficient to
produce
Make a syrup.
4.3 g
48 ml
13.6 g
1.0 g
1.0 g
3.5 g
700 g
50 ml
1000 ml
0.01*4.3=0.043 g
0.01*48=0.48 ml
0.01*13.6=0.136g
0.01*1.0=0.01g
0.01*1=0.01g
0.01*3.5=0.035g
0.01*700=7g
0.01*50=0.5ml
0.01*1000=10 ml
Factor =
Required Quantity/ Quantity
given
= 10 ml/ 1000 ml
= 0.01

9. Name of the
Preparation.
Test Specification Observation
Compound syrup of
ferrous phosphate BPC
1968.
Description
Color
Volume
Odour
Taste
Clear
Black
100 ml
Odourless

10. Compound syrup of ferrous phosphate BPC 1968.
(10 ml )
Ingredients :
Iron-0.043g
PhosphoricAcid-0.48ml
CalciumCarbonate-0.136g
Potassiumbicarbonate-0.01g
SodiumPhosphate-0.01g
Cochineal-0.035g
Sucrose-7g
Orange,Flowerwater-0.5ml
PurifiedWater,Sufficienttoproduce-10ml
Makeasyrup.
Category : Iron and Electrolyte (Calcium, potassium
, sodium ) Supplement in aneamic patient. (Non-
Medicated Syrups )
Direction : As directed by physician.
Storage : Store in airtight container in cool
temperature not exceeding 25 degree centrigrade.
Manufacturing Date -
Expiry Date -
Manufactured by-
Manufacturing Place - Depatment of
Pharmaceutics , East POint College of Pharmacy,
Janaprabha, Bidarahalli.

11. • Reference :
• Dispensing Pharmacy, A Practical Manual, Sanmathi B S,
Kalpesh K Mehta, Anshu Gupta Page No. 107-111
• Text Book :
• Dispensing Pharmacy, Cooper-gun.
• Dispensing Pharmacy , RM Mehta.
• A practical book of Pharmaceutics, Rahul B. Lovhare, Akash
Jain , Dr. Md. Rageeb Md. Usman, Nikam Manohar
Baburao, Page No. 9-10