Just accepted for publication ajp

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This paper describes the the effect of natural bile acids on the avscular system. Secondary bile acids are ligands to GPBAR1 (TGR5) and cause vasodilation in GPBAR1-dependent manner. Bile acids cause the generation of hydrogen sulfide in the vessels.

Science

Just accepted for publication
Renga Barbara, Bucci Maria-Rosaria, Cipriani Sabrina, D’Amore
Claudio, Monti Maria Chiara, Angela Zampella, Gargiulo
Antonella , d’Emmanuele di Villa Bianca Roberta, Eleonora
Distrutti, and Stefano Fiorucci
Cystationine γ-liase, a H2S generating enzyme, is a GPBAR1 regulated gene
and contribute to vasodilation caused by secondary bile acids",
American Journal of Physiology - Heart and Circulatory
Physiology

Ca
GP-BAR1
LCA
cAMP CREB
CRE1 CRE2
CSE
Transcription
H2S
Endothelial cells
PAG
CDCA
BKCa
Smooth muscle cells
IberitoxineNOS
NO
CDCA
FXR
IR1
LCA
CDCA
LCA
Muscarinic receptors
K+
L-NIO

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