Trends in Molecular Medicine

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A review on the role of intestinal microbiota in shaping bile acid pool and how bile acids modulate BAR (bile acid activated receptors) in liver and metabolic disorders.

Science

Fiorucci ‘s laboratory
just published in
Trends in Molecular Medicine
Fiorucci S, Distrutti E.
Bile Acid-Activated Receptors, Intestinal Microbiota,
and the Treatment of Metabolic Disorders. Trends Mol Med. 2015
Oct 16. doi: 10.1016/j.molmed.2015.09.001.

FGF15
GLP1
DCA LCA
Intestinal
Microbiota
BSH activity
L cells
GLP-1
GPBAR1
FGF15
Ileal
Enterocytes
GLP-1R
FGF15
Cyp7A1
CDCA
CA
FXR/RXR
SHP
FXR/RXR
OSTα/β
NTCP
CDCAMRP2
BSEP
MDR1
MRP4
Pancreas-β cell
Insulin
secretion
GLP-1
Portal vein
CDCA, CA,
DCA, LCA
1
2
3
Liver sinusoid
BA
IBAT
FXR/RXR
FGF-R4
Hepatocytes
PXR
VDR
4

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