3. Epidemology
”Spondylitis” affects about 0.1% to
0.5% of the adult population. Although it can
occur at any age, spondylitis most often
strikes men in their teens and 20s.
More common in some Native
American tribes.
4. Etiology
Although the cause of
Spondylitis is unknown,
there is a strong genetic
or family link.
Most, but not all, people
with spondylitis carry a
gene called HLA- B27.
. Although people carrying this gene are more
likely to develop spondylitis, it is
also found in up to 10% of people who have no
signs of the condition.
ly link. Most, but not all, people with spondylitis carry a gene called HLA-B27. Although people carrying this gene are more likely to develop spondylitis, it isalso fou
5. TYPES
Cervical Spondylities :
pain that affects the
cervical spin is called
Cervical Spondylitis.
Lumbar Spondylitis: Pain
in the lumbar region causes
Lumbar Spondylitis.
8. PATHOGENESIS
Immune-mediated.
There is lively controversy
regarding the primary site of
disease initiation.
The inflamed joints are
infiltrated with CD4+
and CD8+ T cells and
macrophages and shows
high levels of TNF-α,
Abundant TGF- α has been found in
more advanced lesions.
9. It is characterized by neutrophils,
macrophages expressing CD68 and CD163,
CD4+ and CD8+ T cells, B cells , ICAM-
1, VCAM-1,
No specific event or exogenous agent that
triggers the onset but reactive arthritis and
inflammatory bowel disease (IBD) suggest
that enteric bacteria may play a role.
Elevated serum titers of antibodies to
certain enteric bacteria but no role for these
antibodies in the pathogenesis of AS
B27 plays a direct role & develop
spondylitis.
10. CLINICAL PRESENTATION
Pain and stiffness
continue for more than three
months. around thesacroiliac
joints.
Bony fusion
Overgrowth of the bones,which
may lead to abnormal joining
of bones.
Pain in ligaments
and tendon
11. Pain in the
buttocks
Arthritis
Enthesitis
Fatigue
14. Physical and occupational
therapy:
For good posture and a good
range of spinal movement,
the patient needs to be
physically active. Exercise
helps to prevent the spine
from being stiff and causing
pain.
Yoga is very effective in treatment of
Spondylitis
15. Surgery: Depending on the patient’s
clinical situation two types.
Joint Replacement
surgery can allow people
to regain the use of joints.
Ostectomy
A surgical procedure that involves cutting
a section of bone in order to shorten or
lengthen the bone itself.
16.
17. MEDICATIONS
Painkillers
NSAIDS
e.g. Aspirin (300-600 mg ,6-8 hrs daily).
Ibuprofen (400-800mg BID)
Naproxen (250mg)
Selective CO II inhibitors:
Celecoxib (100-200mg OD or twice)
Roficoxib (12.5-25mg)
They inhibit COX enzyme in the
following pathway and relief the pain.
19. Corticosteroids : Possible
side effects include a
ruptured tendon near the joint.
e.g. Pridnisone(50-60mg oral)
cortisone (25mg/ml inj)
MO
Steroid molecule
bind to steroid receptors
enter into nucleus
Bind DNA
20. synthesis of specific mRNA
cellular events occur
SIDE EFFECTS
PUD
Avascular necrosis
osteoporosis
Renal toxicity
21. DMARDs (Disease-modifying anti-rheumatic
drugs)
e.g. sulfasalazine
dose: 2 g/day PO div bid
MOA is not known.
Methotrexate
dose: 7.5-25 mg PO bid.
MOA they inhibit folate
reductase enzyme.
Side effects
Headache
Nausea/vomiting
Bone marrow suppression
Liver toxicity
22. Biologics:
Tumor necrosis factor (TNF) blockers
e.g. Etanercept given as a weekly subcutaneous
injection
Remicade (Infliximab) given as a 2-hour IV
infusion every 6 weeks
Humira (Adalimumab) subcutaneous injection given
twice a month.
Simponi (Golimumab) subcutaneous injection
given once a month to treat active ankylosing
spondylitis.
23. MOA
These drugs aim to reduce the amount of
TNF (a protein in the body that triggers
inflammation leading to the symptoms of
ankylosing spondylitis)
Side effects:
Redness,
Swelling,
Itching, rash.
occur at the injection site and typically last no more
than 3 to 5 days.
24. Side effects:
Side effects:
Redness,
Swelling,
Itching, rash.
occur at the injection site and typically last no more
than 3 to 5 days.
