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The Сoncept of Mobile Diagnostic Device by


              МetaScan

               Cambridge - Snezhinsk
Introduction.
  Our team was formed during this competition as a joint venture between




    (Snezhinsk, Russia)                         (Cambridge, Great Britain)

                                 portable
             new                monitor of               new
          technology             prostate             biomarkers
                                pathology

                                                                      МетаСкан
Genomics, proteomics, metabolomics…




                                      МетаСкан
Metabolomics – methods and instruments.

         Total Analytical System (TAS)         Selective Sensors

                                                      FreeStyle
         HPLC-MS

           DFS
                                   HPLC-ECD

              Micro Total Analytical          CoulArray System
                 System (μTAS)

                 i-STAT
                                                            МетаСкан
Portable solutions.
                   Selective Sensors                            i-STAT


                          FreeStyle

                            ~ $ 40                            ~ $ 12 000


      year 1972        year 1995                    year 2000
                                       First portable analyser measuring
  First portable   Modern glucose
                                             in 10 min blood gases,
  glucose meter        meter
                                           electrolytes, some protein
                                       markers, several metabolites and
                                                  haematocrit.
                                                                МетаСкан
Product Overview.
                        Gadget for home use for
                         indication of a problem
                                                             CoulArray System




 disposable cratridge


                    Medical diagnostic device for precise diagnostics
                                                                        МетаСкан
IT solution structure.
Product Overview.

Price estimation for small scale production


• gadget - 400-500 USD;


•disposable cartridge-sensor – 10-15 USD.




                                              МетаСкан
Competitive advantages.
• High diagnostic accuracy

• Affordability, low cost

• Non-invasive

• Easy-to-use

• Immediate result

• Proprietary biomarkers

                             МетаСкан
Business model.

                                      gadget sales

                                       cartridge sales


              license sales to large producers




              sales to professional medical market


                                                         МетаСкан
Risk Management.
 Achieving high specificity and    Use of the combination of several markers
      accuracy of the test        Large clinical trials for high statistical power


                                    CE certification (in Europe) as home use
         Certification
                                                      gadget



                                    Russian patent for technology is present
         IP protection
                                  Further patenting of the device and markers




                                                                            МетаСкан
Team - Oncometrics

               Dr Mikhail Lomonosov, Managing Director, over
               12 years of experience in Cancer Biomarkers and
               Molecular Therapies. Cambridge University.


  Irina Soltamova Solovyev, Director, over 15 years of experience in
     financial consulting and auditing. Founder and Director of group of
                                 companies with international clientele.

              Dr Dmitry Soloviev, Science Director, over 20 years of experience in
              development, synthesis and production of diagnostic
              radiopharmaceuticals for cancer pre-clinical and clinical trials. Cancer
              Research UK

                                                                           МетаСкан
Team-ECOSCAN
                                                                                                   1




     Sergey Sokolkov, PhD,
                                                                                          68
                                                                                     67 100000          2    3
                                                                                66                                4
                                                                           65                                          5
                                                                      64                                                    6




                                                                                                                                                                            Nikolai Zababahin
                                                                 63                                                              7
                                                            62                            10000                                       8
                                                       61                                                                                  9

                                                  60                                                                                            10




     director of “EcoScan”
                                             59                                           1000                                                       11

                                        58                                                                                                                12




                                                                                                                                                                          construction engineer
                                   57                                                                                                                          13
                                                                                           100
                                  56                                                                                                                            14

                              55                                                                                                                                    15

                             54                                                             10                                                                       16


                             53                                                                                                                                      17

                             52                                                                1                                                                     18

                             51                                                                                                                                      19


                             50                                                                                                                                      20

                              49                                                                                                                                    21

                                  48                                                                                                                            22

                                   47                                                                                                                          23

                                        46                                                                                                                24

                                             45                                                                                                      25

                                                  44                                                                                            26

                                                       43                                                                                  27
                                                            42                                                                        28
                                                                 41                                                              29
                                                                      40                                                    30




     Aleksandr Karzhenkov
                                                                           39                                          31
                                                                                38   37                      33   32
                                                                                          36            34
                                                                                                   35




     system integrator                                                                                                                                                                                                 Stanislav Liapin
                                                                                                                                                                                                                      leading developer

     Aleksei Chupurnov
     leading programmer


                                                                                                                                                                                          1,2

                                                                                                                                                                                          1,0

                                                                                                                                                                                          0,8

                                                                                                                                                                                          0,6

                                                                                                                                                                                          0,4




                                                                                                                                                                          Q [rel. unit]
                                                                                                                                                                                          0,2

                                                                                                                                                                                          0,0
                                                                                                                                                                                                 0,0   50,0   100,0   150,0              200,0   250,0   300,0   350,0
                                                                                                                                                                                          -0,2

                                                                                                                                                                                          -0,4




                                                                                                                                                                                                                                                                         МетаСкан
                                                                                                                                                                                          -0,6

                                                                                                                                                                                          -0,8

                                                                                                                                                                                          -1,0
                                                                                                                                                                                                                              t [sec.]
Partners.
 Partners for development of radiation modified high capillary density
 polymer material

 Laboratory ENU, Astana, Kazakhstan

 Affiliated centre of the Institute of

  Nuclear Physics, Astana, Kazakhstan




                                                                         МетаСкан
Road Map.
Phase                             Tasks                          Investments        Time

1.       Technical development                                 4.9 млн. руб.       1 year

2.       Clinical proof of concept, phase 1 clinical trials    2.6 млн. руб.       0,5 year

End of Skolkovo’s grant. Result – concept is proved. Next – bringing in investor

3.      Phase 2 clinical trials                                  20 млн. руб.      1 year

Ready for market

4.      Licensing, preparation for manufacturing                 10 млн. руб.      1 year

5.      Manufacturing and marketing                              40 млн. руб.      1,5 year


                                                                                МетаСкан
Thank you!
                             Contacts:
Соколков Сергей (Снежинск) – ssokolkov@yandex.ru, м.б. +79048186906
   Михаил Ломоносов (Кембридж) - mikhail.lomonosov@gmail.com,
                         +44(7855862351)


                                                                МетаСкан

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Meta scan (снежинск) public-eng

  • 1. The Сoncept of Mobile Diagnostic Device by МetaScan Cambridge - Snezhinsk
  • 2. Introduction. Our team was formed during this competition as a joint venture between (Snezhinsk, Russia) (Cambridge, Great Britain) portable new monitor of new technology prostate biomarkers pathology МетаСкан
  • 4. Metabolomics – methods and instruments. Total Analytical System (TAS) Selective Sensors FreeStyle HPLC-MS DFS HPLC-ECD Micro Total Analytical CoulArray System System (μTAS) i-STAT МетаСкан
  • 5. Portable solutions. Selective Sensors i-STAT FreeStyle ~ $ 40 ~ $ 12 000 year 1972 year 1995 year 2000 First portable analyser measuring First portable Modern glucose in 10 min blood gases, glucose meter meter electrolytes, some protein markers, several metabolites and haematocrit. МетаСкан
  • 6. Product Overview. Gadget for home use for indication of a problem CoulArray System disposable cratridge Medical diagnostic device for precise diagnostics МетаСкан
  • 8. Product Overview. Price estimation for small scale production • gadget - 400-500 USD; •disposable cartridge-sensor – 10-15 USD. МетаСкан
  • 9. Competitive advantages. • High diagnostic accuracy • Affordability, low cost • Non-invasive • Easy-to-use • Immediate result • Proprietary biomarkers МетаСкан
  • 10. Business model. gadget sales cartridge sales license sales to large producers sales to professional medical market МетаСкан
  • 11. Risk Management. Achieving high specificity and Use of the combination of several markers accuracy of the test Large clinical trials for high statistical power CE certification (in Europe) as home use Certification gadget Russian patent for technology is present IP protection Further patenting of the device and markers МетаСкан
  • 12. Team - Oncometrics Dr Mikhail Lomonosov, Managing Director, over 12 years of experience in Cancer Biomarkers and Molecular Therapies. Cambridge University. Irina Soltamova Solovyev, Director, over 15 years of experience in financial consulting and auditing. Founder and Director of group of companies with international clientele. Dr Dmitry Soloviev, Science Director, over 20 years of experience in development, synthesis and production of diagnostic radiopharmaceuticals for cancer pre-clinical and clinical trials. Cancer Research UK МетаСкан
  • 13. Team-ECOSCAN 1 Sergey Sokolkov, PhD, 68 67 100000 2 3 66 4 65 5 64 6 Nikolai Zababahin 63 7 62 10000 8 61 9 60 10 director of “EcoScan” 59 1000 11 58 12 construction engineer 57 13 100 56 14 55 15 54 10 16 53 17 52 1 18 51 19 50 20 49 21 48 22 47 23 46 24 45 25 44 26 43 27 42 28 41 29 40 30 Aleksandr Karzhenkov 39 31 38 37 33 32 36 34 35 system integrator Stanislav Liapin leading developer Aleksei Chupurnov leading programmer 1,2 1,0 0,8 0,6 0,4 Q [rel. unit] 0,2 0,0 0,0 50,0 100,0 150,0 200,0 250,0 300,0 350,0 -0,2 -0,4 МетаСкан -0,6 -0,8 -1,0 t [sec.]
  • 14. Partners. Partners for development of radiation modified high capillary density polymer material Laboratory ENU, Astana, Kazakhstan Affiliated centre of the Institute of Nuclear Physics, Astana, Kazakhstan МетаСкан
  • 15. Road Map. Phase Tasks Investments Time 1. Technical development 4.9 млн. руб. 1 year 2. Clinical proof of concept, phase 1 clinical trials 2.6 млн. руб. 0,5 year End of Skolkovo’s grant. Result – concept is proved. Next – bringing in investor 3. Phase 2 clinical trials 20 млн. руб. 1 year Ready for market 4. Licensing, preparation for manufacturing 10 млн. руб. 1 year 5. Manufacturing and marketing 40 млн. руб. 1,5 year МетаСкан
  • 16. Thank you! Contacts: Соколков Сергей (Снежинск) – ssokolkov@yandex.ru, м.б. +79048186906 Михаил Ломоносов (Кембридж) - mikhail.lomonosov@gmail.com, +44(7855862351) МетаСкан

Editor's Notes

  1. Наше решение - мобильный анализатор метаболитов - использующее новую технологию. Приближающееся по аналитическим возможностям к лабораторным системам.