The document discusses the purpose and content of a Material Safety Data Sheet (MSDS). An MSDS provides detailed information about the hazards of a product, how to safely handle and store it, first aid measures, and other important safety information. It generally contains 16 sections, including product identification, hazard identification, composition, first aid measures, handling and storage, exposure controls, physical properties, stability, toxicological information, and disposal considerations. The document outlines the responsibilities of suppliers, employers, and workers regarding MSDSs and explains the key information included in each section.
Material Safety Data Sheet A Guidelines for Chemical Study
1. MSDS – MATERIAL SAFETY DATA
SHEET
Teacher Incharge
Mr. JITENDRA W. GAJBE
Prof. AISSMS COP , Pune
Presented by
Mr. SHANKAR D. MAIND
M .Pharm (Quality Assurance)
25-07-2023
3. What is a Material Safety Data Sheet
(MSDS)?
• A material safety data sheet is a technical document which
provides detailed and comprehensive information on a
controlled product related to:
• health effects of exposure to the product
• hazard evaluation related to the product’s handling, storage
or use
• measure to protect workers at risk of exposure
• emergency procedures.
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4. The Purpose of the Data Sheet
• The data sheet is the second element of the WHMIS information delivery
system and is
• intended to supplement the alert information provided on labels. The
third element of the
• system is the education of employees in hazard information on controlled
products,
• including instruction in the content and significance of information on the
MSDS
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6. Material Safety Data Sheet Content
• A supplier material safety data sheet must provide at least nine categories
or sections of
• content and approximately sixty items of information distributed among
those categories.
• An MSDS must be reviewed at least every 3 years.
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7. • Generally, an MSDS has 16 sections, each with a fixed heading name, According to the
GHS.
1.Product and Company Identification
2.Hazard(s) identification
3.Composition/information on ingredients
4.First-aid measures
5.Fire-fighting measures
6.Accidental release measures
7.Handling and storage
8.Exposure controls/personal protection
9.Physical and chemical properties
10.Stability and reactivity
11.Toxicological information
12.Ecological information
13.Disposal considerations
14.Transport information
15.Regulatory information
16.Other information.
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8. 1. Product and Company Identification
• Identification of Chemical/Mixture
• Other means of identification.
• Supplier's details (including name, address, phone number, etc.)
• Emergency Phone No.
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9. 2. Hazards Identification
• Hazard Classification
• Hazard symbol including precautionary statements. (Hazard symbols may
be provided as a graphical reproduction of the symbols in black and white
or the name of the symbol, e.g., flame, skull and crossbones.)
• Any other hazard (dust, explosion etc.)
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11. 3. Composition / Information on
Ingredients
• Substance
• Chemical identity.
• Common name, synonyms, etc. CAS number, EC number, etc.
• •Impurities and stabilizing additives which are themselves classified and
which contribute to the classification of the substance.
• The chemical identity and concentration or concentration ranges of all
ingredients which are hazardous within the meaning of the GHS and are
present above their cutoff levels.
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12. CAS Numbering System
• A CAS Registry Number is a numeric identifier that can contain up to 10
digits
• divided by hyphens into three parts.
• The right-most digit is a check digit used to verify the validity and
uniqueness of the entire number.
• For example, 58-08-2 is the CA
• S Registry Number for caffeine.
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13. 4. First Aid Measures
• Description of different routes of exposure, i.e., inhalation, skin and eye
contact, and ingestion.
• Most important symptoms/effects, acute and delayed.
• Indication of immediate medical attention and special treatment needed
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14. 5. Fire Fighting Measures
• Description of different routes of exposure, i.e., inhalation, skin and eye
contact, and ingestion.
• Most important symptoms/effects, acute and delayed.
• Indication of immediate medical attention and special treatment needed
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15. 6. Accidental Release Measures
• Personal precautions , protective equipment and emergency procedures.
• Environmental precautions.
• Methods and materials for containment and cleaning up .
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16. 7. Handling and storage
• Handling and storage
• Precautions for safe handling.
• Condition for safe storage including any incompatibilities
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18. • Threshold Limit Value-Time-Weighted Average, TLV-TWA Time- -
weighted average concentration for an 8-hour workday and a 40-hour
work week in which a worker may be repeated exposed without adverse
health effects.
• Threshold Limit Value-Short-Term Exposure Limit, TLV-STEL -- This is the
maximum concentration which workers can be exposed for 15 minutes
continuously without adverse health affects. Only four of these 15-
minutes exposures are permitted per day and must have 60 minutes
between exposures. The TLV-TWA still must not be exceeded.
• Threshold Limit Value-Ceiling- This is a defined boundary unlike
TLVSwhich are guidelines. It is the concentration which should never
beexceeded at any time during the working exposure.
• Permissible Exposure Limit, PEL- This is one of the most important OSHA
limits used. It is defined as the allowable limit for air contaminant in which
workers may be exposed day after day without adverse health effects.
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19. 9. Physical And Chemical Properties
• Physical and Chemical PropertiesAppearance
• Molecular Weight:
• Flashpoint: oC
• Auto ignition Temperature: oC
• Boiling Point: oC @ 760 mm Hg
• Melting Point: oC
• Vapor Pressure: mm Hg @ 230C
• Vapor Density(Air-1):%
• Solubility in Water: @ 20°C
• Odor/Odor threshold:
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20. 10. Stability and Reactivity
• Stability and Reactivity
• Chemical stability.
• Hazardous Reactions/Decomposition Products
• Possibility of hazardous reactions.
• Conditions to avoid (e.g., static discharge, shock or vibration).
• Incompatible materials
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21. 11. Toxicological Information
• Concise but complete and comprehensible description of the various
toxicological (health) effects and the available data used to identify those
effects, including:
• information on the likely routes of exposure (inhalation, ingestion, skin
and eye contact);
• Symptoms related to the physical, chemical and toxicological
characteristics:
• Target Organ Effects
• Acute and also chronic effects from short- and long-term exposure;
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22. 12. Ecological information
• Ecotoxicity (aquatic and terrestrial, where available).
• Persistence and degradability.
• Bioaccumulative potential.
• Mobility in soil.
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23. 13. Disposal Considerations
• Description of waste residue and information
on their safe handling and disposal including
the disposal of any contaminated packaging.
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24. 14. Transport information
• UN Number.
• UN Proper shipping name.
• Transport Hazard classes.
• Packing group, if applicable.
• Marine pollutant (Yes/No).
• Special precautions which a user needs to be aware of or needs to comply
with in connection with transport or conveyance either within or outside
their premises.
• EX;
• Shipping Name:
• Hazard Class:
• UN/NA Number:
• Packing Group:
• Labels Required:
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26. 16. Other Information
• National Fire Protection Association (NFPA) Ratings: This information is
intended solely for the use of individuals trained in the NFPA system.
• Health:
• Flammability:
• Reactivity: Special Hazard
• Revision Indicator:
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27. Reference
• Canadian centre for Occupational health and safety
https://www.ccohs.ca/products/supplements/msds_ftss/msds_understand.h
tml
• Material Safety data Sheet ,
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-
pharmaceutical-science/material-safety-data-
sheet#:~:text=Generally%2C%20an%20MSDS%20has%2016,Product%20and
%20Company%20Identification
• Safety Data Sheet , https://ehs.research.uiowa.edu/chemical/safety-data-
sheets-sdss
• Hazard Communication Standard ,Safety Data Sheet ,
https://www.osha.gov/sites/default/files/publications/OSHA3514.pdf
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