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1. Brand Gilotrif / Xovoltib
Generic Afatinib
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Gilotrif / Xovoltib Afatinib tablets
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2. What is Afatinib?
Afatinib is used to treat a certain type of non-small cell lung cancer that has spread to other parts of the body.
Afatinib is used for this condition only if your tumor has a specific genetic marker for which your doctor will test.
Afatinib is also used to treat squamous non-small cell lung cancer that has spread to other parts of the body after
other cancer medicine has been tried without successful treatment.
Afatinib may also be used for purposes not listed in this medication guide.
Important Information
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your
medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use afatinib if you are allergic to it.
Tell your doctor if you have ever had:
 kidney disease;
 liver disease;
 heart disease;
breathing problems or lung disease other than cancer; or vision problems, very dry eyes, or if you wear contact
lenses.
Afatinib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using afatinib
and for at least 2 weeks after your last dose. Tell your doctor if you become pregnant.
Do not not breastfeed while using this medicine and for 2 weeks after your last dose.
Source : https://www.drugs.com/mtm/afatinib.html

3. How should I take Afatinib?
Your doctor will perform a blood test to make sure afatinib is the right treatment for your condition.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the
medicine exactly as directed.
 Take afatinib on an empty stomach, at least 1 hour before or 2 hours after a meal.
 Afatinib can cause severe diarrhea, which can be life-threatening if it leads to dehydration. You may be
given medications to prevent or quickly treat diarrhea.
 Your doctor may recommend you have an anti-diarrhea medicine such as loperamide (Imodium)
available at all times while you are taking afatinib. Take the anti-diarrhea medicine as directed on the
label, or as prescribed by your doctor.
 Call your doctor if you are sick with severe diarrhea, or diarrhea lasting longer than 2 days. You may
need to stop taking afatinib for a short time.
 You will need frequent medical tests.
 Store the tablets in their original container at room temperature away from moisture, heat, and light.
Keep the bottle tightly closed when not in use.
 Throw away any afatinib tablets not used before the expiration date on the medicine label.
Source : https://www.drugs.com/mtm/afatinib.html

4. What happens if I miss a dose?
Use the medicine as soon as you can, but skip the missed dose if your next dose
is due in less than 12 hours. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Afatinib?
Afatinib could make you sunburn more easily. Avoid sunlight or tanning beds. Wear
protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Source : https://www.drugs.com/mtm/afatinib.html

5. Afatinib side effects
Get emergency medical help if you have signs of an allergic reaction:
 hives; difficult breathing; swelling of your face, lips, tongue, or throat.
 Stop using afatinib and call your doctor at once if you have:
 new or worsening cough, fever, or trouble breathing;
 severe or ongoing diarrhea (lasting 2 days or longer);
 severe skin reaction that causes blistering and peeling;
 pain, redness, numbness, and peeling skin on your hands or feet;
 blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
 eye problems--eye pain or redness, blurred vision, watery eyes, feeling like something is in your eye,
increased sensitivity to light;
 liver problems--stomach pain (upper right side), easy bruising or bleeding, feeling tired, dark urine, clay-
colored stools, jaundice (yellowing of the skin or eyes); orheart problems--pounding heartbeats or fluttering
in your chest, shortness of breath (even with mild exertion), swelling in your legs or ankles, rapid weight
gain.
Source : https://www.drugs.com/mtm/afatinib.html

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Genuine Gilotrif / Xovoltib - Afatinib ?
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