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Overview: The Key Roles of Cell Division
The ability of organisms to reproduce
best distinguishes living things from
nonliving matter
The continuity of life is based on the
reproduction of cells, or cell division
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
(a) Reproduction (b) Growth and development
(c) Tissue renewal
Phases of the Cell Cycle
The cell cycle consists of
Interphase (cell growth and
copying of chromosomes in
preparation for cell division)
Mitotic (M) phase (mitosis and
cytokinesis)
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
Interphase (about 90% of the cell cycle) can
be divided into sub-phases:
G1 phase (“first gap”)
S phase (“synthesis”)
G2 phase (“second gap”)
The cell grows during all three phases, but
chromosomes are duplicated only during the
S phase
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
Fig. 12-5
S
(DNA synthesis)
G1
G2
Mitosis is conventionally divided into four
phases:
Prophase
Metaphase
Anaphase
Telophase
Cytokinesis is well underway by late telophase
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
Structure of Chromosomes
 The centromere is a
constricted region of the
chromosome containing a
specific DNA sequence, to
which is bound 2 discs of
protein called kinetochores.
 Kinetochores serve as points
of attachment for
microtubules that move the
chromosomes during cell
division:
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Metaphase chromosome
Kinetochore
Kinetochore
microtubules
Centromere
region of
chromosome
Sister Chromatids
Mitosis and
Meiosis
Mitosis and Meiosis
Mitosis:
-division of somatic (body) cells
Meiosis
-division of gametes (sex cells)
Interphase
1.Cell preparing to divide
2.Genetic material doubles
Prophase
1. Chromosomes thicken and shorten
-become visible
-2 chromatids joined by a centromere
2. Centrioles move to the opposite sides of the
nucleus
3. Nucleolus disappears
4. Nuclear membrane disintegrate
Metaphase
 Chromosomes meet in the middle!
1. Chromosomes arrange at equator of cell
2. Become attached to spindle fibres by
centromeres
3. Homologous chromosomes do not associate
Anaphase
 Chromosomes get pulled
apart
1. Spindle fibres contract pulling
chromatids to the opposite
poles of the cell
Telophase
 Now there are two!
1. Chromosomes uncoil
2. Spindle fibres disintegrate
3. Centrioles replicate
4. Nuclear membrane forms
5. Cell divides
Meiosis
4 daughter cells produced
Each daughter cell has half the
chromosomes of the parent
2 sets of cell division involved
The Cell Cycle (Mitosis & Meiosis)
The Cell Cycle (Mitosis & Meiosis)

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The Cell Cycle (Mitosis & Meiosis)

  • 1.
  • 2. Overview: The Key Roles of Cell Division The ability of organisms to reproduce best distinguishes living things from nonliving matter The continuity of life is based on the reproduction of cells, or cell division Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
  • 3. (a) Reproduction (b) Growth and development (c) Tissue renewal
  • 4. Phases of the Cell Cycle The cell cycle consists of Interphase (cell growth and copying of chromosomes in preparation for cell division) Mitotic (M) phase (mitosis and cytokinesis) Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
  • 5. Interphase (about 90% of the cell cycle) can be divided into sub-phases: G1 phase (“first gap”) S phase (“synthesis”) G2 phase (“second gap”) The cell grows during all three phases, but chromosomes are duplicated only during the S phase Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
  • 7. Mitosis is conventionally divided into four phases: Prophase Metaphase Anaphase Telophase Cytokinesis is well underway by late telophase Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
  • 8. Structure of Chromosomes  The centromere is a constricted region of the chromosome containing a specific DNA sequence, to which is bound 2 discs of protein called kinetochores.  Kinetochores serve as points of attachment for microtubules that move the chromosomes during cell division: Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Metaphase chromosome Kinetochore Kinetochore microtubules Centromere region of chromosome Sister Chromatids
  • 10. Mitosis and Meiosis Mitosis: -division of somatic (body) cells Meiosis -division of gametes (sex cells)
  • 11. Interphase 1.Cell preparing to divide 2.Genetic material doubles
  • 12. Prophase 1. Chromosomes thicken and shorten -become visible -2 chromatids joined by a centromere 2. Centrioles move to the opposite sides of the nucleus 3. Nucleolus disappears 4. Nuclear membrane disintegrate
  • 13.
  • 14. Metaphase  Chromosomes meet in the middle! 1. Chromosomes arrange at equator of cell 2. Become attached to spindle fibres by centromeres 3. Homologous chromosomes do not associate
  • 15.
  • 16. Anaphase  Chromosomes get pulled apart 1. Spindle fibres contract pulling chromatids to the opposite poles of the cell
  • 17. Telophase  Now there are two! 1. Chromosomes uncoil 2. Spindle fibres disintegrate 3. Centrioles replicate 4. Nuclear membrane forms 5. Cell divides
  • 18.
  • 19. Meiosis 4 daughter cells produced Each daughter cell has half the chromosomes of the parent 2 sets of cell division involved