Bad Fish (Fish Toxins)

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Richin Koshy

Fish Toxins

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.DEFINITION OF FISH PHARMACOLOGY: “Fish pharmacology is essential for undertaking treatment of fishes using any therapeutic chemicals or drugs.” “Pharmacology is the study of the interaction of chemicals with living system.” “Pharmacology” is morden science which correlated other biological sciences, eg., Biochemistry , Physiology Microbiology , Medicine , and Genetics. “Pharmacology is the branch of biology concerned with the study of drug action.” “Pharmacology is the study of drugs including their origins, history, uses, and properties. It mainly focuses on the actions of drugs on the body.” “Pharmacology is the study of drugs and theire actions on the body”. “Pharmacology is the study of substance that interact with living systems through chemical process, especially by binding to regulatory molecules &activating or inhibiting normal body process. Fig. 1 3. HISTORY OF FISH PHARMACOLGY: Pharmacology emerged as its own discipline in the 19th Century, branching off from research done in fields of science such as organic chemistry and physiology. Oswald Schmiedeberg, who was born in what is now Latvia in 1838, is considered the father of pharmacology. His doctoral thesis was on the measurement of chloroform levels in blood, and he went on to become a professor of pharmacology at the University of Strasburg, where he ran an institute of pharmacology. There, he studied chloroform, which was used as an anesthetic, chloral hydrate, a sedative and hypnotic, and muscarine, a compound isolated from the mushroom Amanita muscaria that stimulates the parasympathetic nervous system and has been used to treat various diseases such as glaucoma. In 1890, John Jacob Abel became the first pharmacology chair in the United States, at the University of Michigan. He later went to Johns Hopkins University in Baltimore. Abel was the first to isolate the hormone epinephrine from the adrenal gland, isolate histamine from the pituitary gland, and make pure crystalline insulin. Animals such as dogs, cats, pigeons, and frogs were used to test pharmacological substances. Humans were even used as test subjects. Sometimes they suffered through severe adverse effects from these substances, such as when the German pharmacist Friedrich Serturner and three of his friends had poisoning for several days from an alkaloid that Serturner had isolated from opium. This alkaloid was later named morphine, after the Ancient Greek god of sleep, Morpheus. Oswald Schmiedeberg was a brilliant scientist. He studied the pharmacology of various compounds, including chloroform, and published an important text called the Outline of Pharmacology. There, he studied chloroform, which was used as an anesthetic, chloral hydrate, a sedative and hypnotic, and muscarine, a compound isolated from the mush to the field, Schmiedeberg is now known as 'the father of pharmacology'.

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