A brief presentation on Patient Related factor & Antibody-Enzyme Based Tumor Targetting.

1. Prepared By
MD. RAFIUL HOQUE
Department of PHARMACY
Noakhali Science & Technology University

2.  Topic 1. Patient Related Factors
 Topic 2. Antibody & Enzyme Based Tumor
Targeting

4. Modification in protein-Drug binding as
influenced by age of the patient is mainly
due to differences in the protein content in
various age groups.
1. Neonates: Unbound concentration of
drug primarily bind to albumin.
2. Young Infants: Infants should be given
low doses considering their poorly
developed drug eliminating system.

5. 3. Elderly: In old age, the albumin content is
lowered & free concentration of drugs that
bind primarily to it is increased.

6. Intersubject variability in drug binding as
studied with few drugs showed that the
difference is small & no more than two fold.
These differences have been attributed to
genetic & environmental factors.

7. Several pathologic conditions are associated
with alteration in protein content.
Disease Influence on
plasma
protein
Influence on
protein-drug
bindding
1. Renal failure Decreased
albumin
content
Decreased
binding of
acidic drugs.
2. Hepatic
failure
Decreased
albumin
synthesis
Decreased
binding of
acidic drugs.
3. Inflammatory
States
Increased
AAG levels
Increased
Binding of
basic drugs.

9. Targeted drug delivery system is special form of
drug delivery system where the medicament is
selectively targeted to or delivered only to its
site of action or absorption.
Tumor is an abnormal growth of cells. They are
two types,
1. Malignant Tumor.
2. Benign Tumor.

10.  Monoclonal antibodies (mAbs) used for the
killing of tumor cells.
 The enzyme-antibody complex bind wirh
the antigen of tumor cells.
 At the same time, the prodrug is converted
to the active drug which is active against
the tumor cells.