The current gap between basic science research and the development of new analgesics presents a serious challenge for the future of pain medicine. In addition to technical constraints like the inability of animal pain models to simulate multidimensional clinical pain conditions, it also involves alarmingly rising drug development costs and timelines. The uncertainty of a site’s ability to meet study obligations further compromises planning efforts while inconsistent recruitment across sites leads to study delay. QPS is an independent, global player in the field of contract research, with facilities in the USA, the Netherlands, Austria, India, China and Taiwan engaging more than 900 qualified and experienced professionals. Our unique management models, new technologies, and creative study approaches can combat the increasing timelines and costs of your clinical trials. Our unparalleled competence in drug metabolism and pharmacokinetics, toxicology, bioanalysis, translational medicine, and early stage and phase II – IV clinical research can reduce your time-to-market and minimize your costs. QPS will plan your clinical study from start to finish, putting the right team and protocol in place to make certain your trial runs smoothly.

1. PAIN MANAGEMENT
CLINICAL TRIALS THE WORLD OVER,
HAVE ONE NAME - QPS
STUDY SITES
TIMELINES
DRUG
DEVELOPMENT
COSTS
PAIN MODELS

2. PAIN MANAGEMENT –
A GLOBAL FOOTPRINT
WHY
More than 1.5 billion people worldwide suffer from
chronic pain.
CHOOSE
Approximately 3 - 4.5% of the global population
suffers from neuropathic pain, with incidence rate
increasing with age.
Worldwide, 37% of low back pain was attributed to
occupation, with two-fold variation across regions. QPS?
Work-related low back pain was estimated to cause
818,000 disability-adjusted life years lost annually.
Knowledge and
Experience = Expertise
CURRENT CHALLENGES QPS is an independent, global player in the field of
contract research, with facilities in the USA, the
The current gap between basic science research and the
Netherlands, Austria, India, China and Taiwan engaging
development of new analgesics presents a serious challenge for
more than 900 qualified and experienced professionals. Our
the future of pain medicine. In addition to technical constraints
unique management models, new technologies, and creative
like the inability of animal pain models to simulate
study approaches can combat the increasing timelines and
multidimensional clinical pain conditions, it also involves
costs of your clinical trials. Our unparalleled competence in
alarmingly rising drug development costs and timelines. The
drug metabolism and pharmacokinetics, toxicology,
uncertainty of a site’s ability to meet study obligations further
bioanalysis, translational medicine, and early stage and phase
compromises planning efforts while inconsistent recruitment
II – IV clinical research can reduce your time-to-market and
across sites leads to study delays.
minimize your costs. QPS will plan your clinical study from start
to finish, putting the right team and protocol in place to make
certain your trial runs smoothly.

3. DEDICATED FRAMEWORK OF mediate or conduct phase IIb and III pain studies. Via its
INTEGRATED PAIN RESEARCH dedicated framework of integrated pain research services,
SERVICES QPS offers a full range of outsourcing solutions from ‘first in
Recently, QPS has extended its service portfolio by adding human’ to ‘first in patient’ (proof of concept) to late stage
more pain research facilities and expertise. For phase I and pain studies.
IIa investigations of both nociceptive and neuropathic pain,
the Quantitative Sensory Testing Battery (QST) and the Third EXTENSIVE EXPERIENCE IN
Molar Extraction Model (M3) are available. In the QST COMBINATION WITH STATE OF THE
battery, cold/heat and mechanical/pressure thresholds are ART FACILITIES
measured in healthy volunteers to investigate pain/flare and Over the past two decades, QPS has performed thousands
primary/secondary hyperalgesia. The M3 model is of preclinical and clinical studies for local and international
performed in collaboration with the Department of Orofacial pharmaceutical and biotechnology companies, covering
Surgery of the University Medical Center Groningen in the numerous disease therapies. QPS provides one of the
Netherlands, a large facility that provides easy subject largest capacities in bioanalysis for small molecules and
recruitment and high recruitment rates. Both pain and biologics, as well as specialized biomarker assay
anti‐inflammatory biomarkers can be measured on request. capabilities. Our early stage clinical research facilities
Especially the combination of both pain models in the same comprise more than 400 phase I beds. Over the past 15
person who needs M3 surgery twice on different sites offers years, QPS phase I sites have collectively completed more
the opportunity to investigate a nociceptive and than a thousand clinical trials often including data
anti‐hyperalgesic effect simultaneously. QPS manages a management, biostatistics, PK/PD evaluation and medical
network of pain clinicians in both university and writing as well.
non‐university hospitals through which we may either
PHASE I BEDS
AROUND THE GLOBE
240
USA
40
TAIWAN
92
INDIA
54
NETHERLANDS

4. SPEEDY PATIENT RECRUITMENT QPS FOR YOUR NEXT PAIN MANAGEMENT
QPS ensures speedy patient recruitment through powerful CLINICAL TRIAL
associations with efficient study sites across Europe, USA and Whether you need clinical trials of small molecules, biologics,
Asia, innovative patient recruitment strategies, and close links or other medications, QPS has the experience and resources
with academia, SMOs, and specialist networks. We maintain a to handle your trials and get your product to market. Choose
large worldwide database of investigators to ensure high QPS for your next pain management trial! Should you want to
enrollment rates of patients selected according to strict discuss your questions in more detail with one of our experts,
eligibility criteria. A specialized QPS team works 24/7 to offer please contact us directly at: info@qps.com
solutions that increase patient enrollment rates.
EXPERIENCED INVESTIGATORS
QPS works closely with our principal investigators to ensure
that your studies are recruited on time and with qualified
subjects. The strong relationships we forge with the
investigators who conduct your clinical trials promote the
performance of quality studies. We take pride in the fact that
the skills of the most experienced investigators are applied to
every clinical trial QPS conducts.
REFERENCES:-
1. Mao J. Current challenges in translational pain research. Trends Pharmacol Sci. 2012 Sep 5.
2. AAPM Facts and Figures on Pain. The American Academy of Pain Medicine. Available at
http://www.painmed.org/patientcenter/facts_on_pain.aspx. Accessed on 1/11/2012.
3. Punett L et al. Estimating the global burden of low back pain attributable to combined
occupational exposures. American Journal of Industrial Medicine.
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