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RESEARCHMISCONDUCTDr. Priya Bhave Chittawar
The lazy person‘s guide to research?In a world of ‗publish or perish‘ is there a medicineto help us• Rise to the occasion•...
A pill for every woe…
What is the evidence on Laigra?How Many Scientists Fabricate and Falsify Research?A Systematic Review and Meta-Analysis of...
Research Misconduct• What?• Who?• Why?• How to prevent?• How to detect?
Types• Falsification• Fabrication• Plagiarism
How fraud affects us?• Breast cancer treatment• Cardioprotective diet• Red wine and the heart
1. Breast cancer treatment• NSBAP project• Mastectomy versus lumpectomy in treatment of Ca breast• ―Life-table estimates f...
NSBAP trial• Major misconduct by one of the contributors Dr. Poisson(  Montreal)• Ineligible patients recruited, data fudg...
•
• Findings did not change after excluding the  cohort of patients from St Luc Hospital• Cast a shadow on the findings.• No...
The Story of RamBMJ, 1992 Apr 18;304(6833):1015-9.Randomised controlled trial of cardioprotectivediet in patients with rec...
Cont….• 550 patients of myocardial infarction• One year of low fat, high fibre diet• Half risk of death due to all causes•...
If something is too good to be true, it is probablynot.
The Expose`BMJ. 2005 July 30; 331(7511): 281–288.Suspected research fraud: difficulties of getting atthe truthCaroline Whi...
Dr. Ram B.Singh• First author on 28 full articles between 1989 and 1993,• Five large intervention trials within the space ...
The best succumb…• Chamberlain: transposition of an ectopic  pregnancy to the uterus.• Andrew Weikfield: MMR vaccine with ...
How fraud affects us?• Breast cancer treatment• Cardioprotective diet• Red wine and the heart
Responsibility of authors• Duplication• Guest/gift authorship• Keep raw data• Conflict of interest• Ethical considerations
Responsibility of Institutions• INVESTIGATE• RETRACT• PREVENT• STEP DOWN
COLLEAGUES
JOURNALS• Retract• Expression of concern• Corrections
Research:
Don‘t just do it, Do it right!
The Lazy person‘s guide to research
Thankyou!
Research misconduct
Research misconduct
Research misconduct
Research misconduct
Research misconduct
Research misconduct
Research misconduct
Research misconduct
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Research misconduct

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While we depend more and more on research to make our clinical decisions, research misconduct is a malady that seriously undermines the credibility of the evidence generated. It is universal, ubiquitous and more common than we know

Published in: Health & Medicine, Business

Research misconduct

  1. 1. RESEARCHMISCONDUCTDr. Priya Bhave Chittawar
  2. 2. The lazy person‘s guide to research?In a world of ‗publish or perish‘ is there a medicineto help us• Rise to the occasion• Perform research and publish it• Fast track work• Get personal and professional acclaim INSTANTLY!
  3. 3. A pill for every woe…
  4. 4. What is the evidence on Laigra?How Many Scientists Fabricate and Falsify Research?A Systematic Review and Meta-Analysis of Survey DataDaniele Fanelli ( Plos 2009)*21 studies*Scientists admitting misconduct( falsification andfabrication) : 1.97% (95%CI: 0.86–4.45)*Other misconduct ( QRP): 33%*Scientists observing misconduct: 14%(CI: 9.91–19.72)*Observing QRP: 28.53%, (CI:18.85–38.2)
  5. 5. Research Misconduct• What?• Who?• Why?• How to prevent?• How to detect?
  6. 6. Types• Falsification• Fabrication• Plagiarism
  7. 7. How fraud affects us?• Breast cancer treatment• Cardioprotective diet• Red wine and the heart
  8. 8. 1. Breast cancer treatment• NSBAP project• Mastectomy versus lumpectomy in treatment of Ca breast• ―Life-table estimates five and eight years after surgery indicated that 90 percent of women who underwent lumpectomy followed by breast irradiation remained free of cancer in the ipsilateral breast. The rates of disease- free survival, survival free of disease at distant sites, and overall survival were not significantly different from those among patients who underwent either total mastectomy or lumpectomy alone. ‖
  9. 9. NSBAP trial• Major misconduct by one of the contributors Dr. Poisson( Montreal)• Ineligible patients recruited, data fudged and altered to suit the results.• Office of research integrity( ORI)
  10. 10.
  11. 11. • Findings did not change after excluding the cohort of patients from St Luc Hospital• Cast a shadow on the findings.• No longer powered to detect a clinically significant difference
  12. 12. The Story of RamBMJ, 1992 Apr 18;304(6833):1015-9.Randomised controlled trial of cardioprotectivediet in patients with recent acute myocardialinfarction: results of one year follow up.Singh RB, Rastogi SS, Verma R,Laxmi B,SinghR,Ghosh S,Niaz MA.Medical Hospital and ResearchCentre, Moradabad, India.
  13. 13. Cont….• 550 patients of myocardial infarction• One year of low fat, high fibre diet• Half risk of death due to all causes• Cited 225 times• Still on the Pubmed
  14. 14. If something is too good to be true, it is probablynot.
  15. 15. The Expose`BMJ. 2005 July 30; 331(7511): 281–288.Suspected research fraud: difficulties of getting atthe truthCaroline White, freelance medical journalist1―When research misconduct is suspected and theresearcher is working outside the jurisdiction ofofficial research bodies, there is nowhere foreditors to turn. If they want to investigate theirconcerns, they are invariably forced to go italone—a lengthy, costly, and difficult process‖
  16. 16. Dr. Ram B.Singh• First author on 28 full articles between 1989 and 1993,• Five large intervention trials within the space of 18 months• BMJ, AJC , Lancet, IJC and other high impact journals• Who should carry out the research?• ICMR
  17. 17. The best succumb…• Chamberlain: transposition of an ectopic pregnancy to the uterus.• Andrew Weikfield: MMR vaccine with autism• Scott Reuben: Pain management• Dr. Anil Potti: genomics in chemotherapy
  18. 18. How fraud affects us?• Breast cancer treatment• Cardioprotective diet• Red wine and the heart
  19. 19. Responsibility of authors• Duplication• Guest/gift authorship• Keep raw data• Conflict of interest• Ethical considerations
  20. 20. Responsibility of Institutions• INVESTIGATE• RETRACT• PREVENT• STEP DOWN
  21. 21. COLLEAGUES
  22. 22. JOURNALS• Retract• Expression of concern• Corrections
  23. 23. Research:
  24. 24. Don‘t just do it, Do it right!
  25. 25. The Lazy person‘s guide to research
  26. 26. Thankyou!

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