Drug Excipient Interaction and it's different methods that includes physical interaction, chemical interaction,Biopharmaceutical interaction. Along with different analytical methods used to detect drug Excipient Interactions.
2. Shri Balasaheb Mane Shikshan Prasarak Mandal Ambap’s
ASHOKRAO MANE COLLEGE OF PHARMACY,PETH VADGAON
TITLE OF SEMINAR: DRUG EXCIPIENT INTERACTION
AND ITS DIFFERENT METHODS
SUBJECT: MP (MODERN PHARMACEUTICS)
Academic Year: 2023-24
Preparedby: Guided by:
Miss .Prajakta. R. Patil Dr.Sachin.S.Mali
M.pharm FirstYear ProfessorandHead, Department
Roll no-11 of Pharmaceutics.
Department of Pharmaceutics
4. INTRODUCTION
• Excipients plays an important role in formulating a dosage form
• An excipient is a substanceformulated alongside the active ingredient of a
medication includedfor the purpose of long term stabilization.
• Excipients are inactive ingredients that serves as carriers for the active
ingredients in a pharmaceuticalproduct.
• Excipients are classified into following categories:
▪ Diluents
▪ Binder
▪ Disintegrants
▪ Lubricants
▪ Glidants
▪ Colouringagent
5. Ideal Properties of Excipient
Excipients
Cost
effective
Feasible
Non-toxic
Stable for
handling
Physiologically
inert
6. DRUG EXCIPIENT INTERACTION
In pharmaceuticaldosage forms the active pharmaceuticalingredients are in
intimate contactwith the excipient which are greater quantityexcipient and
drugs may have certain incompatibilitywhich lead to drug excipient interaction.
7. Types of drug excipient
Interactions
▪ 1. Physical interactions
▪ 2.Chemical interactions
▪ 3.Biopharmaceutical interactions
8. Interaction
Complexation :
1. Usually binds reversibly with drugs to form complex
2.Insoluble complexes are formed which lead to slower
dissolution
3. Decreased absorption of drug
9. PHYSICAL INTERACTION
• Physical interactions alter rate of dissolution, dosage
uniformity,etc.
• Physical interactions are most common but difficult to detect.
• Physical interactions do not involve chemical changes thus
permitting the components in the formulation to retain their
molecular structure
10. Beneficial effect example
• Cyclodextrin is often used to improve bioavailability of poorly water
soluble drugs.
• This increases bioavailability and increases rate
Detrimental effect example
• Tetracycline formed insolublecomplex with calcium carbonateleadingto
slower dissolutionand decreased absorption
11. CHEMICAL INTERACTION
• It involves chemical reaction between drugs and excipients or drug
and impurities present in the excipients to form different
molecules
• Chemical interactions are almost detrimental to product as they
produce degradation
• They are as follows:
1. Chemical interaction between drug and excipients
2. Interaction of drug with excipient residues or impurities
12. 1.Chemical interaction between drug and excipient
Examples:
Release of Diclofenac sodium from matrix tablet was
inhibited by polymer (Chitosan) at low pH,due to formation of
ionic complex between Diclofenac sodium and ionized cationic
polymer.
2. Interaction between drug and excipient residues/impurities
Examples:
Excipient Residues
Povidone peroxide
Magnesium stearate Antioxidant
13. BIOPHARMACEUTICAL INTERACTION
• These interactions are observed after administration of medicine
• These interactions occurs between medicine(drug/excipient) and
the body fluids
• The interaction have the tendency to influence the rate of
absorption of the drug
• Examples:
Premature breakdown of enteric coat, if this occur side effects
lie gastric bleeding occurs in case of NSAIDs.
14. ANALYTICAL METHODS TO DETECT DRUG-
EXCIPIENT INTERACTION
1.Thermal Methods
i. DSC Differential Scanning Calorimetry
ii. DTA Differential Thermal Analysis
2. Spectroscopic Techniques
i. FT-IR spectroscopy
ii. Powder X-ray diffraction
3. Chromatography
i. TLC
ii. HPLC
4.Accelerated Stability Study
